公开(公告)号：US20170095421A1

公开(公告)日：2017-04-06

申请号：US15143738

申请日：2016-05-02

申请人： MARIA I.C. GYONGYOSSY-ISSA ,  Jayachandran N. Kizhakkedathu ,  Iren Constantinescu ,  William Campbell ,  Carlos A. Del Carpio Munoz

发明人： MARIA I.C. GYONGYOSSY-ISSA ,  Jayachandran N. Kizhakkedathu ,  Iren Constantinescu ,  William Campbell ,  Carlos A. Del Carpio Munoz

IPC分类号： A61K9/127 ,  A61K35/19

CPC分类号： A61K9/1271 ,  A61K9/1277 ,  A61K35/19 ,  A61K47/6911

摘要： A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.

公开(公告)号：US20170095420A1

公开(公告)日：2017-04-06

申请号：US15143711

申请日：2016-05-02

申请人： MARIA I.C. GYONGYOSSY-ISSA ,  Jayachandran N. Kizhakkedathu ,  Iren Constantinescu

发明人： MARIA I.C. GYONGYOSSY-ISSA ,  Jayachandran N. Kizhakkedathu ,  Iren Constantinescu

IPC分类号： A61K9/127

CPC分类号： A61K9/1271 ,  A61K9/1277 ,  A61K35/19 ,  A61K47/6911

摘要： A method for producing a composition of lipidic particles coated with a cross-linked surface mesh, the method comprising the steps of: (i) preparing lipidic particles comprising pharmaceutically acceptable lipids, (ii) binding hydrophilic polymer chains to the surface of the lipidic particles, and (iii) cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh. Pharmaceutical compositions comprising surface modified lipidic particles prepared according to this method are also described. The lipidic particles resist fusion with red blood cells and platelets in vitro, and are amenable to further derivatization by targeting molecules for controlled release of component and contents, thus providing a new generation of drug carrier systems.