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    SYNTHETIC PLATELETS
    1.
    发明申请
    SYNTHETIC PLATELETS 审中-公开
    合成胶片

    公开(公告)号：US20080213369A1

    公开(公告)日：2008-09-04

    申请号：US11851718

    申请日：2007-09-07

    申请人： Maria I.C. Gyongyossy-Issa ,  Jayachandran N. Kizhakkedathu ,  Iren Constantinescu ,  William Campbell ,  Carlos A. Del Carpio Munoz

    发明人： Maria I.C. Gyongyossy-Issa ,  Jayachandran N. Kizhakkedathu ,  Iren Constantinescu ,  William Campbell ,  Carlos A. Del Carpio Munoz

    IPC分类号： A61K9/14 ,  A61K38/00 ,  A61P9/00

    CPC分类号： A61K9/1271 ,  A61K9/1277 ,  A61K35/19 ,  A61K47/6911

    摘要： A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.

    摘要翻译： 一种与血小板和（亚）内皮相互作用的合成血小板替代物，其包含：（a）包含具有交联表面网的脂质颗粒的载体分子，所述脂质颗粒包含：药学上可接受的形成颗粒的脂质的内脂质颗粒 ; 亲水性聚合物链与脂质颗粒的表面连接，亲水性聚合物链在其自由端包含可交联端基; 和连接亲水性聚合物链的端基以形成交联表面网的交联剂基团; 和（b）至少一个连接于载体分子表面的受体分子。 受体分子可以是特异于参与血小板功能的配体的肽部分。

    High molecular weight chelation structure
    5.
    发明申请
    High molecular weight chelation structure 失效
    高分子量螯合结构

    公开(公告)号：US20070274945A1

    公开(公告)日：2007-11-29

    申请号：US11441359

    申请日：2006-05-25

    申请人： Mark D. Scott ,  Jayachandran N. Kizhakkedathu

    发明人： Mark D. Scott ,  Jayachandran N. Kizhakkedathu

    IPC分类号： A61K31/785 ,  C08G63/91 ,  C08G63/48

    CPC分类号： A61K31/785 ,  A61K47/58 ,  A61K47/60 ,  Y02A50/411

    摘要： A chelation structure and method of forming and using the chelation structure. The chelation structure has a backbone that includes a linear sequence of monomeric backbone units, at least one polymer side chain, and at least one chelator side chain. The side chains are each covalently coupled to the backbone at one of the monomeric backbone units by a bond that is independently biodegradable or non-biodegradable. The chelation structure is synthesized by Radical Addition Fragmentation Transfer (RAFT), Atom Transfer Radical Polymerization (ATRP), or Free Radical Polymerization (FRP). The chelation structure, individually or in combination with a shuttle chelator, may be introduced into a mammal to bind an amount of a substance in a mammal, the substance being at least one of a metal and heme. The chelation structure has a log stability constant exceeding that of the shuttle chelator for binding the substance within cells of the mammal.

    摘要翻译： 一种螯合结构和形成和使用螯合结构的方法。 螯合结构具有主链，其包括单体主链单元，至少一个聚合物侧链和至少一个螯合剂侧链的线性序列。 侧链通过单独的可生物降解或不可生物降解的键共价偶联到单体主链单元之一的骨架上。 螯合结构通过自由基加成转移（RAFT），原子转移自由基聚合（ATRP）或自由基聚合（FRP）合成。 螯合结构单独地或与穿梭螯合剂组合可以引入到哺乳动物中以结合一定量的哺乳动物物质，该物质是金属和血红素中的至少一种。 螯合结构的对数稳定性常数超过用于结合哺乳动物细胞内的物质的穿梭螯合剂的对数稳定性。

    High molecular weight chelation structure
    7.
    发明授权
    High molecular weight chelation structure 失效
    高分子量螯合结构

    公开(公告)号：US08454934B2

    公开(公告)日：2013-06-04

    申请号：US11441359

    申请日：2006-05-25

    申请人： Mark D. Scott ,  Jayachandran N. Kizhakkedathu

    发明人： Mark D. Scott ,  Jayachandran N. Kizhakkedathu

    IPC分类号： A61K51/00 ,  A61M36/14

    CPC分类号： A61K31/785 ,  A61K47/58 ,  A61K47/60 ,  Y02A50/411

    摘要： A chelation structure and method of forming and using the chelation structure. The chelation structure has a backbone that includes a linear sequence of monomeric backbone units, at least one polymer side chain, and at least one chelator side chain. The side chains are each covalently coupled to the backbone at one of the monomeric backbone units by a bond that is independently biodegradable or non-biodegradable. The chelation structure is synthesized by Radical Addition Fragmentation Transfer (RAFT), Atom Transfer Radical Polymerization (ATRP), or Free Radical Polymerization (FRP). The chelation structure, individually or in combination with a shuttle chelator, may be introduced into a mammal to bind an amount of a substance in a mammal, the substance being at least one of a metal and heme. The chelation structure has a log stability constant exceeding that of the shuttle chelator for binding the substance within cells of the mammal.

    摘要翻译： 一种螯合结构和形成和使用螯合结构的方法。 螯合结构具有主链，其包括单体主链单元，至少一个聚合物侧链和至少一个螯合剂侧链的线性序列。 侧链通过单独的可生物降解或不可生物降解的键共价偶联到单体主链单元之一的骨架上。 螯合结构通过自由基加成转移（RAFT），原子转移自由基聚合（ATRP）或自由基聚合（FRP）合成。 螯合结构单独地或与穿梭螯合剂组合可以引入到哺乳动物中以结合一定量的哺乳动物物质，该物质是金属和血红素中的至少一种。 螯合结构的对数稳定性常数超过用于结合哺乳动物细胞内的物质的穿梭螯合剂的对数稳定性。