公开(公告)号：US20240003792A1

公开(公告)日：2024-01-04

申请号：US17928177

申请日：2021-04-19

申请人： MDimune Inc.

发明人： Shin Gyu Bae ,  Seung Wook Oh ,  Dong Woo Han

IPC分类号： G01N1/40

CPC分类号： G01N1/4077 ,  G01N2001/4088

摘要： Provided is a method for preparing cell-derived vesicles, and more particularly, a method for preparing cell-derived vesicles using a cell extruder, and a syringe-type cell extruder for effectively preparing cell-derived vesicles. According to the present invention, by using the method for preparing the cell-derived vesicles and the cell extruder, it is possible to prepare cell-derived vesicles in a stable, economical, and mass-producible manner.

公开(公告)号：US20230257434A1

公开(公告)日：2023-08-17

申请号：US17758825

申请日：2021-01-13

申请人： MDimune Inc. ,  Seoul National University R&DB Foundation

发明人： Shin Gyu Bae ,  Seung Wook Oh ,  Joong Hoon Park ,  Tae Sub Park

IPC分类号： C07K14/47 ,  C12N5/07 ,  C07K14/705 ,  A61K38/17 ,  A61P21/00

CPC分类号： C07K14/4722 ,  C12N5/06 ,  C07K14/70596 ,  A61K38/17 ,  A61P21/00 ,  C12N2510/00

摘要： The present invention relates to cell-derived vesicles comprising target protein Prokineticin receptor 1 (PROKR1), and a therapeutic agent for muscle diseases comprising the same. When applied to myoblasts, the cell-derived vesicles comprising PROKR1 according to the present invention promote muscle differentiation and induce differentiation into myotubes, and can thus be used to prevent or treat muscle diseases and can be widely used in the pharmaceutical industry and the field of health functional foods.