公开(公告)号：US20240317696A1

公开(公告)日：2024-09-26

申请号：US18559968

申请日：2022-05-10

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Weizhi GE ,  Shaolong LI ,  Guoli ZHANG ,  Shuhui CHEN

IPC分类号： C07D307/16 ,  A61K31/167 ,  A61K31/341 ,  C07C233/55

CPC分类号： C07D307/16 ,  A61K31/167 ,  A61K31/341 ,  C07C233/55 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2602/14 ,  C07C2602/38 ,  C07C2602/42

摘要： A series of alkyl carboxylic acid compounds and an application thereof, and relates in particular to compounds represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210317109A1

公开(公告)日：2021-10-14

申请号：US17274206

申请日：2019-09-09

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Maoyi LEI ,  Yong WANG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D405/14 ,  C07D405/04 ,  C07D491/048 ,  C07D493/04

摘要： Disclosed is a series of tricyclic substituted piperidine dione compounds, and applications thereof in the preparation of medicines for treating diseases related to CRBN protein; specifically disclosed are the derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240246985A1

公开(公告)日：2024-07-25

申请号：US18574378

申请日：2022-06-23

申请人： MEDSHINE DISCOVERY INC.

发明人： Sheng SU ,  Yunfu LUO ,  Guoli ZHANG

IPC分类号： C07D487/04 ,  A61K31/437

CPC分类号： C07D487/04 ,  A61K31/437

摘要： Provided are a crystal form of a triazolopyridine-substituted indazole compound and a preparation method therefor; and specifically disclosed are a crystal form of a compound as represented by formula (I) and a preparation method therefor.

公开(公告)号：US20230158152A1

公开(公告)日：2023-05-25

申请号：US17906557

申请日：2021-03-17

申请人： MEDSHINE DISCOVERY INC.

发明人： Maoyi LEI ,  Lei PENG ,  Yunfu LUO ,  Yu XU ,  Junmiao LI ,  Xinyuan DENG ,  Zisheng KANG ,  Weizhi GE ,  GuoIi ZHANG ,  Shuhui CHEN

IPC分类号： A61K47/54

CPC分类号： A61K47/545

摘要： A proteolysis targeting chimera (PROTAC), and an application thereof in preparation of a drug for treating a related disease. Specifically disclosed are a compound as represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20200223801A1

公开(公告)日：2020-07-16

申请号：US16468127

申请日：2017-12-11

申请人： Medshine Discovery Inc.

发明人： Yunfu LUO ,  Yuyong BA ,  Shuhui CHEN

IPC分类号： C07D233/58 ,  C07D249/08 ,  C07D213/34

摘要： Provided is a CCR2/CCR5 receptor antagonist and the use thereof in the preparation of a drug for treating diseases associated with the CCR2/CCR5. In particular, disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190210975A1

公开(公告)日：2019-07-11

申请号：US16325626

申请日：2017-08-22

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Chundao YANG ,  Maoyi LEI ,  Lanbao SUN ,  Guoping HU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D235/26 ,  C07D263/58 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10 ,  C07D401/10

摘要： Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230322745A1

公开(公告)日：2023-10-12

申请号：US18027049

申请日：2021-09-28

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Peng ZHANG ,  Yunfu LUO ,  Feng GAO ,  Shuhui CHEN

IPC分类号： C07D409/14 ,  C07D413/14 ,  C07D491/107 ,  C07D487/04 ,  C07D491/056 ,  C07D491/048

CPC分类号： C07D409/14 ,  C07D413/14 ,  C07D491/107 ,  C07D487/04 ,  C07D491/056 ,  C07D491/048

摘要： Disclosed are a fused tricyclic derivative and a pharmaceutical application thereof. Specifically disclosed are a compound represented by formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230183221A1

公开(公告)日：2023-06-15

申请号：US17998355

申请日：2021-05-19

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu LUO ,  Yuyong BA ,  Shuhui CHEN

IPC分类号： C07D405/14

CPC分类号： C07D405/14

摘要： Disclosed are a series of compounds having pyridine structures or pharmaceutically acceptable salts thereof, and an application thereof in the preparation of drugs for the treatment of related diseases. Specifically, disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20210317138A1

公开(公告)日：2021-10-14

申请号：US17274236

申请日：2019-09-09

申请人： MEDSHINE DISCOVERY INC.

发明人： Maoyi LEI ,  Yunfu LUO ,  Yu XU ,  Guoli ZHANG ,  Jinghong DONG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D513/04 ,  C07D405/04 ,  C07D405/12 ,  C07D491/048 ,  A61P35/00 ,  C07D498/04

摘要： Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20200339549A1

公开(公告)日：2020-10-29

申请号：US16960468

申请日：2019-01-11

申请人： MEDSHINE DISCOVERY INC.

发明人： Bin CHEN ,  Xiawei WEI ,  Xuefeng SUN ,  Lei ZHANG ,  Zhaoying XU ,  Wenli LI ,  Peng ZHANG ,  Feng GAO ,  Yunfu LUO ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D405/12 ,  C07D307/81 ,  C07D211/54 ,  C07D409/12 ,  C07D215/38 ,  C07D333/52 ,  C07D277/64 ,  C07D417/12 ,  C07D413/12 ,  C07D491/048 ,  A61P11/00

摘要： A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.