公开(公告)号：US11319330B2

公开(公告)日：2022-05-03

申请号：US17274236

申请日：2019-09-09

申请人： MEDSHINE DISCOVERY INC.

发明人： Maoyi Lei ,  Yunfu Luo ,  Yu Xu ,  Guoli Zhang ,  Jinghong Dong ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D405/04 ,  C07D405/12 ,  C07D513/04 ,  C07D491/048 ,  C07D498/04 ,  A61P35/00

摘要： Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11905276B2

公开(公告)日：2024-02-20

申请号：US17642064

申请日：2020-09-14

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu Luo ,  Maoyi Lei ,  Yu Xu ,  Junmiao Li ,  Guoli Zhang ,  Jinghong Dong ,  Shuhui Chen

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D491/107 ,  C07D409/04 ,  C07D491/048 ,  C07D487/08 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D413/04

CPC分类号： C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107 ,  C07D495/04 ,  C07D498/04

摘要： A compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and disclosed is an application thereof in the preparation of a medication for treating diseases related to a CRBN receptor.