公开(公告)号：US11325907B2

公开(公告)日：2022-05-10

申请号：US16965377

申请日：2019-01-29

申请人： MEDSHINE DISCOVERY INC.

发明人： Maoyi Lei ,  Yu Xu ,  Yunfu Luo

IPC分类号： C07D471/04 ,  A61P19/02

摘要： Disclosed are a crystal form of 1H-imidazo[4,5-b]pyridine-2(3H)-one compound and a preparation process therefor, and use of the crystal form in the manufacture of a medicament for treating a disease associated with PDE4 receptor.

公开(公告)号：US11319330B2

公开(公告)日：2022-05-03

申请号：US17274236

申请日：2019-09-09

申请人： MEDSHINE DISCOVERY INC.

发明人： Maoyi Lei ,  Yunfu Luo ,  Yu Xu ,  Guoli Zhang ,  Jinghong Dong ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D405/04 ,  C07D405/12 ,  C07D513/04 ,  C07D491/048 ,  C07D498/04 ,  A61P35/00

摘要： Disclosed are a series of tricyclic furan-substituted piperidinedione compounds and an application thereof in preparing a drug for treating a disease related to CRBN protein. In particular, disclosed is a derivative compound represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11136315B2

公开(公告)日：2021-10-05

申请号：US16960468

申请日：2019-01-11

申请人： MEDSHINE DISCOVERY INC.

发明人： Bin Chen ,  Xiawei Wei ,  Xuefeng Sun ,  Lei Zhang ,  Zhaoying Xu ,  Wenli Li ,  Peng Zhang ,  Feng Gao ,  Yunfu Luo ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D405/12 ,  A61P11/00 ,  C07D211/54 ,  C07D215/38 ,  C07D277/64 ,  C07D307/81 ,  C07D333/52 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D491/048

摘要： A compound as a CXCR2 antagonist and an application thereof in preparing a drug as a CXCR2 antagonist. In particular, the present invention relates to a compound represented by formula (II) or an isomer or pharmaceutically acceptable salt thereof.

公开(公告)号：US10532986B2

公开(公告)日：2020-01-14

申请号：US16325626

申请日：2017-08-22

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu Luo ,  Chundao Yang ,  Maoyi Lei ,  Lanbao Sun ,  Guoping Hu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D235/26 ,  C07D263/58 ,  C07D401/04 ,  C07D403/04 ,  C07D403/06 ,  C07D405/04 ,  C07D409/04 ,  C07D417/04 ,  A61P29/00 ,  A61K31/423 ,  A61P37/00 ,  A61K31/4184 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D417/10

摘要： Provided are a phosphodiesterase-4 (PDE4) inhibitor and application thereof in preparation of a medication for treating a disease related to PDE4. Specifically disclosed is a compound as shown in formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220119376A1

公开(公告)日：2022-04-21

申请号：US17273997

申请日：2019-09-09

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Maoyi Lei ,  Yunfu Luo ,  Yu Xu ,  Guoli Zhang ,  Zhijuan Yu ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D413/14 ,  C07D498/04 ,  C07D413/04 ,  A61P35/00

摘要： The present invention discloses a series of tricyclic compounds and use thereof in preparing a medicament for treating a disease related to CRBN protein. Specifically, the present invention discloses a derivative compound of formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11155523B2

公开(公告)日：2021-10-26

申请号：US16468127

申请日：2017-12-11

申请人： Medshine Discovery Inc.

发明人： Yunfu Luo ,  Yuyong Ba ,  Shuhui Chen

IPC分类号： C07D233/64 ,  C07D213/34 ,  C07D213/56 ,  C07D249/08 ,  C07D233/58

摘要： Provided is a CCR2/CCR5 receptor antagonist and the use thereof in the preparation of a drug for treating diseases associated with the CCR2/CCR5. In particular, disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240317722A1

公开(公告)日：2024-09-26

申请号：US18580401

申请日：2022-07-12

申请人： Medshine Discovery Inc.

发明人： Maoyi Lei ,  Yu Xu ,  Yunfu Luo ,  Shuhui Chen

IPC分类号： C07D405/04 ,  A61K31/4525

CPC分类号： C07D405/04 ,  A61K31/4525

摘要： A heteroaryl-3-piperidinedione compound and the use thereof. Particularly disclosed are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US11905276B2

公开(公告)日：2024-02-20

申请号：US17642064

申请日：2020-09-14

申请人： MEDSHINE DISCOVERY INC.

发明人： Yunfu Luo ,  Maoyi Lei ,  Yu Xu ,  Junmiao Li ,  Guoli Zhang ,  Jinghong Dong ,  Shuhui Chen

IPC分类号： C07D405/04 ,  C07D405/14 ,  C07D491/107 ,  C07D409/04 ,  C07D491/048 ,  C07D487/08 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D413/04

CPC分类号： C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D487/04 ,  C07D487/08 ,  C07D491/048 ,  C07D491/107 ,  C07D495/04 ,  C07D498/04

摘要： A compound represented by formula (III) or a pharmaceutically acceptable salt thereof, and disclosed is an application thereof in the preparation of a medication for treating diseases related to a CRBN receptor.