公开(公告)号：US3801460A

公开(公告)日：1974-04-02

申请号：US3801460D

申请日：1970-12-18

申请人： MERCK & CO INC

发明人： STOUDT T ,  LONG R

IPC分类号： C12P33/00 ,  C07C167/08 ,  C07C167/14

CPC分类号： C12P33/00 ,  Y10S435/834

摘要： The invention disclosed herein relates to the process in which an 11-desoxy-3-oxygenated - Delta 4-steroid is subjected to the action of Bacillus cereus microorganisms thereby effecting simultaneous oxygenation (i.e., 11-hydroxylation) and Delta 1dehydrogenation of the steroid to produce an 11 Beta -hydroxy-3oxygenated- Delta 1,4steroid. For example, the 11-desoxy-3oxygenated- Delta 4steroid, Compound S, is converted directly by this microbiological oxygenation-dehydrogenation procedure to its 11 Beta -hydroxy- Delta 1-dehydro analog, prednisolone, which is known to be useful as an anti-inflammatory agent.