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    Process for preparing acetals and ketals of 2beta,16alpha,17alpha-trihydroxy seroids
    2.
    发明授权
    Process for preparing acetals and ketals of 2beta,16alpha,17alpha-trihydroxy seroids 失效
    制备2BETA，16ALPHA，17ALPHA-TRIHYDROXY SEROIDS的乙酸和乙酯的方法

    公开(公告)号：US3600280A

    公开(公告)日：1971-08-17

    申请号：US3600280D

    申请日：1969-06-06

    申请人： PATRICK A DIASSI ,  PACIFICO A PRINCIPE

    发明人： DIASSI PATRICK A ,  PRINCIPE PACIFICO A

    IPC分类号： C12P33/00 ,  C07C167/08

    CPC分类号： C12P33/00 ,  Y10S435/912

    摘要： THIS INVENTION RELATES TO THE PRODUCTION OF ACETALS AND KETALS OF 2B,16A-DIHYDROXYHYDROCORTISONE AND ACYL DERIVATIVES THEREOF. THESE COMPOUNDS ARE PREPARED BY SUBJECTING ACETALS AND KETALS OF 16A-HYDROXYCORTEXOLONE TO THE ACTION OF ENZYMES OF ABSIDIA COERULEA. THE FINAL PRODUCTS OF THIS INVENTION ARE THERAPEUTICALLY USEFUL COMPOUNDS POSSESSING ANTI-INFLAMMATORY AND PROGESTATIONAL ACIVITY. IN ADDITION, THE PRODUCTS OF THIS INVENTION ARE USEFUL AS ANTI-OXIDANTS AND ANTI-CORROSIVE AGENTS. THEY ARE ALSO SURFACTANTS AND THUS MAY BE EMPLOYED AS EMULSIFIERS AND WETTING AGENTS.

    Simultaneous steroid oxygenation and 1-dehydrogenation with bacillus cereus
    6.
    发明授权
    Simultaneous steroid oxygenation and 1-dehydrogenation with bacillus cereus 失效
    同时采用BACILLUS CEREUS进行同种异烟肼氧化和1-脱氢酶

    公开(公告)号：US3801460A

    公开(公告)日：1974-04-02

    申请号：US3801460D

    申请日：1970-12-18

    申请人： MERCK & CO INC

    发明人： STOUDT T ,  LONG R

    IPC分类号： C12P33/00 ,  C07C167/08 ,  C07C167/14

    CPC分类号： C12P33/00 ,  Y10S435/834

    摘要： The invention disclosed herein relates to the process in which an 11-desoxy-3-oxygenated - Delta 4-steroid is subjected to the action of Bacillus cereus microorganisms thereby effecting simultaneous oxygenation (i.e., 11-hydroxylation) and Delta 1dehydrogenation of the steroid to produce an 11 Beta -hydroxy-3oxygenated- Delta 1,4steroid. For example, the 11-desoxy-3oxygenated- Delta 4steroid, Compound S, is converted directly by this microbiological oxygenation-dehydrogenation procedure to its 11 Beta -hydroxy- Delta 1-dehydro analog, prednisolone, which is known to be useful as an anti-inflammatory agent.