公开(公告)号：US20180238914A1

公开(公告)日：2018-08-23

申请号：US15753388

申请日：2016-08-19

申请人： METANOMICS GMBH ,  RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG

发明人： Philipp Schatz ,  Henning Witt ,  Erik Peter ,  Martin Dostler ,  Susan Carvalho ,  Philipp Ternes ,  Philipp Mappes ,  Jenny Fischer ,  Hugo A. Katus ,  Tanja Weis ,  Norbert Frey

IPC分类号： G01N33/92 ,  G01N33/68

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing a cardiac disease in a subject based on determining the amounts of at least three lipid metabolite biomarkers and at least one further cardiac biomarker. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

公开(公告)号：US20160209433A1

公开(公告)日：2016-07-21

申请号：US14914815

申请日：2014-09-01

申请人： METANOMICS GMBH ,  RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG

发明人： Henning Witt ,  Juergen Kastler ,  Bianca Bethan ,  Erik Peter ,  Philipp Schatz ,  Hans Dirk Duengen ,  Tobias Daniel Trippel ,  Elvis Tahirovic ,  Hugo A. Katus ,  Norbert Frey ,  Tanja Weis

IPC分类号： G01N33/92 ,  G06F19/28

CPC分类号： G01N33/92 ,  G01N33/6893 ,  G01N2405/08 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/325 ,  G16B50/00

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject based on a group of biomarkers. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

摘要翻译： 本发明涉及诊断方法领域。 具体地，本发明考虑了一种用于基于一组生物标志物来诊断受试者的心力衰竭的方法。 本发明还涉及用于执行上述方法的工具，例如诊断装置。

公开(公告)号：US20170285049A1

公开(公告)日：2017-10-05

申请号：US15507801

申请日：2015-09-01

申请人： METANOMICS GMBH ,  Ruprecht-Karls-Universität Heidelberg

发明人： Philipp Schatz ,  Henning Witt ,  Martin Dostler ,  Susan Carvalho ,  Erik Peter ,  Philipp Ternes ,  Philipp Mappes ,  Hans Dirk ,  Tobias Daniel ,  Elvis Tahirovic ,  Hugo Katus ,  Norbert Frey ,  Tanja Weis

IPC分类号： G01N33/92

CPC分类号： G01N33/92 ,  G01N33/6893 ,  G01N2405/00 ,  G01N2405/02 ,  G01N2405/04 ,  G01N2405/08 ,  G01N2800/325

摘要： The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject based on determining the amounts of at least three biomarkers. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.

公开(公告)号：US20170212135A1

公开(公告)日：2017-07-27

申请号：US15329669

申请日：2015-07-28

申请人： Metanomics GMBH ,  Ruprecht-Karls-Universität Heidelberg

发明人： Philipp Schatz ,  Henning Witt ,  Erik Peter ,  Philipp Ternes ,  Philipp Mappes ,  Hogo A. Katus ,  Tanja Weis ,  Norbert Frey ,  Hans Dirk Duengen ,  Tobias Daniel Trippel ,  Elvis Tahirovic

IPC分类号： G01N33/92 ,  C12Q1/60

CPC分类号： G01N33/92 ,  C12Q1/60 ,  G01N33/502 ,  G01N2405/08 ,  G01N2800/325

摘要： The present invention relates to diagnostic means and methods for heart failure. In particular, the invention relates to a method for diagnosing heart failure in a subject suspected to suffer therefrom comprising determining the amount of at least one cholesterol parameter and/or total sphingomyelins and/or triacylglycerols in a sample of the said subject, and comparing the amount(s) determined in step (a) to a reference, whereby it is diagnosed whether the subject suffers from heart failure, or not. Moreover, the invention pertains to a device for diagnosing whether a subject suffers from heart failure, or not, and to the use, in general, of enzymatic detection agents for at least one cholesterol parameter and/or total sphingomyelins and/or triacylglycerols for diagnosing in a sample of a subject whether the said subject suffers from heart failure, or not. Finally, contemplated is a kit for diagnosing heart failure in subject suspected to suffer therefrom.