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公开(公告)号：US10930370B2
公开(公告)日：2021-02-23
申请号：US15607364
申请日：2017-05-26
Applicant: Microsoft Technology Licensing, LLC
Inventor： Karin Strauss , Siena Dumas Ang , Luis Ceze , Yuan-Jyue Chen , Hsing-Yeh Parker , Bichlien Nguyen , Robert Carlson
IPC: G16B30/00 , C12Q1/6869 , G16B30/20 , G16B50/40
Abstract: Artificial polynucleotides may have different characteristics than natural polynucleotides so conventional base-calling algorithms may make incorrect base calls. However, because artificial polynucleotides are typically designed to have certain characteristics, the known characteristics of the artificial polynucleotide can be used to modify the base-calling algorithm. This disclosure describes polynucleotide sequencers adapted to sequence artificial polynucleotides by modifying a base-calling algorithm of the polynucleotide sequencer according to known characteristics of the artificial polynucleotides. The base-calling algorithm analyzes raw data generated by a polynucleotide sequencer and identifies which nucleotide base occupies a given position on a polynucleotide strand.
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公开(公告)号：US20180253528A1
公开(公告)日：2018-09-06
申请号：US15607364
申请日：2017-05-26
Applicant: Microsoft Technology Licensing, LLC
Inventor： Karin Strauss , Siena Dumas Ang , Luis Ceze , Yuan-Jyue Chen , Hsing-Yeh Parker , Bichlien Nguyen , Robert Carlson
CPC classification number: G16B30/00 , C12Q1/6869 , G16B30/20 , C12Q2537/165 , C12Q2563/107 , C12Q2565/607
Abstract: Artificial polynucleotides may have different characteristics than natural polynucleotides so conventional base-calling algorithms may make incorrect base calls. However, because artificial polynucleotides are typically designed to have certain characteristics, the known characteristics of the artificial polynucleotide can be used to modify the base-calling algorithm. This disclosure describes polynucleotide sequencers adapted to sequence artificial polynucleotides by modifying a base-calling algorithm of the polynucleotide sequencer according to known characteristics of the artificial polynucleotides. The base-calling algorithm analyzes raw data generated by a polynucleotide sequencer and identifies which nucleotide base occupies a given position on a polynucleotide strand.
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公开(公告)号：US11896945B2
公开(公告)日：2024-02-13
申请号：US16597799
申请日：2019-10-09
Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor： Bichlien Hoang Nguyen , Karin Strauss , Hsing-Yeh Parker
CPC classification number: B01J19/0046 , C07K1/042 , C25D5/16 , C25D5/48 , C25D17/10 , B01J2219/0059 , B01J2219/00497 , B01J2219/00596 , B01J2219/00612 , B01J2219/00722 , B01J2219/00725
Abstract: High surface area coatings are applied to solid substrates to increase the surface area available for solid-phase synthesis of polymers. The high surface area coatings use three-dimensional space to provide more area for functional groups to bind polymers than an untreated solid substrate. The polymers may be oligonucleotides, polypeptides, or another type of polymer. The solid substrate is a rigid supportive layer made from a material such as glass, a silicon material, a metal material, and plastic. The coating may be thin films, hydrogels, microparticles. The coating may be made from a metal oxide, a high-κ dielectric, a low-κ dielectric, an etched metal, a carbon material, or an organic polymer. The functional groups may be hydroxyl groups, amine groups, thiolate groups, alkenes, n-alkenes, alkalines, N-Hydroxysuccinimide (NHS)-activated esters, polyaniline, aminosilane groups, silanized oxides, oligothiophenes, and diazonium compounds. Techniques for applying coatings to solid substrates and attaching functional groups are also disclosed.
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公开(公告)号：US12157102B2
公开(公告)日：2024-12-03
申请号：US17863033
申请日：2022-07-12
Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor： Bichlien H. Nguyen , Douglas P. Kelley , Karin Strauss , Robert Carlson , Hsing-Yeh Parker , John Mulligan , Luis H. Ceze , Yuan-Jyue Chen , Douglas Carmean
IPC: B01J19/00
Abstract: A system includes a synthesizer unit having a fluid input to receive fluids and a communication input to receive commands to synthesize data-encoded DNA sequences and cleave the DNA. A first flexible chemistry reaction chamber module may be fluidically coupled to the synthesizer unit to receive the data-encoded DNA sequences and amplify the sequences. A deposition unit may be fluidically coupled to the first flexible chemistry reaction chamber module to receive the amplified DNA sequences and encapsulate the amplified DNA sequences into one or more wells in a storage plate for storage and retrieval to and from a plate storage unit. Retrieved DNA may be processed and read by further units.
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Patent Agency Ranking
公开(公告)号：US12115510B2
公开(公告)日：2024-10-15
申请号：US17695734
申请日：2022-03-15
Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor： Bichlien Hoang Nguyen , Karin Strauss , Hsing-Yeh Parker
CPC classification number: B01J19/0046 , C07K1/042 , C25D5/16 , C25D5/48 , C25D17/10 , B01J2219/00497 , B01J2219/0059 , B01J2219/00596 , B01J2219/00612 , B01J2219/00722 , B01J2219/00725
Abstract: High surface area coatings are applied to solid substrates to increase the surface area available for solid-phase synthesis of polymers. The high surface area coatings use three-dimensional space to provide more area for functional groups to bind polymers than an untreated solid substrate. The polymers may be oligonucleotides, polypeptides, or another type of polymer. The solid substrate is a rigid supportive layer made from a material such as glass, a silicon material, a metal material, and plastic. The coating may be thin films, hydrogels, microparticles. The coating may be made from a metal oxide, a high-κ dielectric, a low-κ dielectric, an etched metal, a carbon material, or an organic polymer. The functional groups may be hydroxyl groups, amine groups, thiolate groups, alkenes, n-alkenes, alkalines, N-Hydroxysuccinimide (NHS)-activated esters, polyaniline, aminosilane groups, silanized oxides, oligothiophenes, and diazonium compounds. Techniques for applying coatings to solid substrates and attaching functional groups are also disclosed.
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公开(公告)号：US11607660B2
公开(公告)日：2023-03-21
申请号：US16597799
申请日：2019-10-09
Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor： Bichlien Hoang Nguyen , Karin Strauss , Hsing-Yeh Parker
Abstract: High surface area coatings are applied to solid substrates to increase the surface area available for solid-phase synthesis of polymers. The high surface area coatings use three-dimensional space to provide more area for functional groups to bind polymers than an untreated solid substrate. The polymers may be oligonucleotides, polypeptides, or another type of polymer. The solid substrate is a rigid supportive layer made from a material such as glass, a silicon material, a metal material, and plastic. The coating may be thin films, hydrogels, microparticles. The coating may be made from a metal oxide, a high-κ dielectric, a low-κ dielectric, an etched metal, a carbon material, or an organic polymer. The functional groups may be hydroxyl groups, amine groups, thiolate groups, alkenes, n-alkenes, alkalines, N-Hydroxysuccinimide (NHS)-activated esters, polyaniline, aminosilane groups, silanized oxides, oligothiophenes, and diazonium compounds. Techniques for applying coatings to solid substrates and attaching functional groups are also disclosed.
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公开(公告)号：US11439970B2
公开(公告)日：2022-09-13
申请号：US15986425
申请日：2018-05-22
Applicant: Microsoft Technology Licensing, LLC
Inventor： Bichlien H Nguyen , Douglas P Kelley , Karin Strauss , Robert Carlson , Hsing-Yeh Parker , John Mulligan , Luis H Ceze , Yuan-Jyue Chen , Douglas Carmean
Abstract: A system includes a synthesizer unit having a fluid input to receive fluids and a communication input to receive commands to synthesize data-encoded DNA sequences and cleave the DNA. A first flexible chemistry reaction chamber module may be fluidically coupled to the synthesizer unit to receive the data-encoded DNA sequences and amplify the sequences. A deposition unit may be fluidically coupled to the first flexible chemistry reaction chamber module to receive the amplified DNA sequences and encapsulate the amplified DNA sequences into one or more wells in a storage plate for storage and retrieval to and from a plate storage unit. Retrieved DNA may be processed and read by further units.
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公开(公告)号：US11305253B2
公开(公告)日：2022-04-19
申请号：US16597799
申请日：2019-10-09
Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor： Bichlien Hoang Nguyen , Karin Strauss , Hsing-Yeh Parker
Abstract: High surface area coatings are applied to solid substrates to increase the surface area available for solid-phase synthesis of polymers. The high surface area coatings use three-dimensional space to provide more area for functional groups to bind polymers than an untreated solid substrate. The polymers may be oligonucleotides, polypeptides, or another type of polymer. The solid substrate is a rigid supportive layer made from a material such as glass, a silicon material, a metal material, and plastic. The coating may be thin films, hydrogels, microparticles. The coating may be made from a metal oxide, a high-κ dielectric, a low-κ dielectric, an etched metal, a carbon material, or an organic polymer. The functional groups may be hydroxyl groups, amine groups, thiolate groups, alkenes, n-alkenes, alkalines, N-Hydroxysuccinimide (NHS)-activated esters, polyaniline, aminosilane groups, silanized oxides, oligothiophenes, and diazonium compounds. Techniques for applying coatings to solid substrates and attaching functional groups are also disclosed.
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公开(公告)号：US20210106967A1
公开(公告)日：2021-04-15
申请号：US16597799
申请日：2019-10-09
Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC
Inventor： Bichlien Hoang Nguyen , Karin Strauss , Hsing-Yeh Parker
Abstract: High surface area coatings are applied to solid substrates to increase the surface area available for solid-phase synthesis of polymers. The high surface area coatings use three-dimensional space to provide more area for functional groups to bind polymers than an untreated solid substrate. The polymers may be oligonucleotides, polypeptides, or another type of polymer. The solid substrate is a rigid supportive layer made from a material such as glass, a silicon material, a metal material, and plastic. The coating may be thin films, hydrogels, microparticles. The coating may be made from a metal oxide, a high-κ dielectric, a low-κ dielectric, an etched metal, a carbon material, or an organic polymer. The functional groups may be hydroxyl groups, amine groups, thiolate groups, alkenes, n-alkenes, alkalines, N-Hydroxysuccinimide (NHS)-activated esters, polyaniline, aminosilane groups, silanized oxides, oligothiophenes, and diazonium compounds. Techniques for applying coatings to solid substrates and attaching functional groups are also disclosed.
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