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    5,5-Diphenyl-3-(piperidino, tetrahydropyridyl-1-and piperazino)-hydantoins
    1.
    发明授权
    5,5-Diphenyl-3-(piperidino, tetrahydropyridyl-1-and piperazino)-hydantoins 失效
    5,5-二苯基-3-（哌啶子基，四氢吡啶基-1-哌嗪基） - 乙内酰脲

    公开(公告)号：US3892748A

    公开(公告)日：1975-07-01

    申请号：US38102173

    申请日：1973-07-20

    Applicant: MILES LAB

    Inventor： HAYAO SHIN ,  HAVERA HERBERT JOHN ,  STRYCKER WALLACE GLENN

    IPC: C07D211/52 ,  C07D233/72 ,  C07D51/70

    CPC classification number: C07D233/72 ,  C07D211/52 ,  Y10S514/821

    Abstract: 3-substituted-5,5-diphenylhydantoin derivatives in which the 5,5-diphenylhydantoin moiety is attached at C3 by a loweralkylene bridge to a 4-phenyl-1-piperidyl, 4-hydroxy-4-phenyl-1-piperidyl, 4-phenyl-1,2,3,6-tetrahydropyridyl, 4-phenyl-1-piperazinyl, or loweralkylamino group are useful in the treatment of cardiac arrhythmias in mammals. One or both of the 5,5-diphenyl substituents optionally can be substituted in the ortho-, meta-, or para-positions with halogeno, loweralkyl, loweralkoxy, amino or nitro groups.

    Abstract translation: 3-取代-5,5-二苯基乙内酰脲衍生物，其中5,5-二苯基乙内酰脲部分在C3下通过亚烷基桥连接到4-苯基-1-哌啶基，4-羟基-4-苯基-1-哌啶基，4 苯基-1,2,3,6-四氢吡啶基，4-苯基-1-哌嗪基或低级烷基氨基可用于治疗哺乳动物心律失常。 在邻位，间位或对位与卤代，低级烷基，低级烷氧基，氨基或硝基中的一个或两个任选地可以被取代。

    (phenyl piperidino alkyl)3 4-dihydrocarbostyrils
    2.
    发明授权
    (phenyl piperidino alkyl)3 4-dihydrocarbostyrils 失效
    （PHENYL PIPERIDINO ALKYL）3 4-DIHYDROCARBOSTYRILS

    公开(公告)号：US3629266A

    公开(公告)日：1971-12-21

    申请号：US3629266D

    申请日：1969-03-03

    Applicant: MILES LAB

    Inventor： HAVERA HERBERT JOHN

    IPC: C07D215/22 ,  C07D215/227 ,  C07D33/52

    CPC classification number: C07D215/227

    Abstract: 1-SUBSTITUTED DERIVATIVES OF 3,4-DIHYDROCARBOSTYRIL THAT ARE USEFUL AS ANALGESIC AGENTS. THESE COMPOUNDS ARE PREPARED BY REACTING A 3,4-DIHYDROCARBOSTYRIL OR SUBSTITUTED 3,4-DIHYDROCARBOSTYRIL WITH A SUITABLE HALOALKYLAMINE.

    Abstract translation: 1-取代的3,4-二氢喹诺酮的衍生物，其可用作止痛剂。 这些化合物通过使3,4-二氢喹诺酮或取代的3,4-二氢喹诺酮与合适的卤代烷基胺反应来制备。

    Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
    4.
    发明授权
    Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones 失效
    1,3代表2,4（1H，3H） - 喹唑啉的衍生物

    公开(公告)号：US3879393A

    公开(公告)日：1975-04-22

    申请号：US37127773

    申请日：1973-06-18

    Applicant: MILES LAB

    Inventor： HAVERA HERBERT JOHN

    IPC: C07D401/06 ,  C07D51/48

    CPC classification number: C07D401/06 ,  Y10S514/929

    Abstract: The disclosed derivatives of 1,3-disubstituted 2,4 (1H,3H)quinazolinediones produce vasodilation in experimental animals. The 1,3-disubstitutions include, among others, 1(alky(alkylamino))-, 1-(alkylpiperidyl)-, 3-(alkyl(alkylamino))-, 3-(alkyl(4-phenyl-1-piperidyl)-, and 3-(alkyl(4-phenyl-1piperazinyl))-moieties. In the latter two substituents the phenyl group optionally is substituted with halogeno or loweralkyl groups. Additionally, the compounds optionally are substituted at carbon atoms 5 through 8 of the quinazolinedione nucleus with halogeno, nitro, alkoxy, and alkylamido substituents.

    Abstract translation: 公开的1,3-二取代的2,4（1H，3H） - 喹唑啉二酮的衍生物在实验动物中产生血管舒张。 1,3-二取代基包括1- [烷基（烷基氨基）] - ，1-（烷基哌啶基） - ，3- [烷基（烷基氨基）] - ，3- [烷基（4-苯基-1-哌啶基 ] - 和3- [烷基（4-苯基-1-哌嗪基）] - 部分，在后两个取代基中，苯基任选被卤代或低级烷基取代。另外，化合物任选地在碳原子5 8具有卤代，硝基，烷氧基和烷基酰氨基取代基的喹唑啉二酮核。

    N-benzyl-N-{8 2-phenyl-2-(4-phenyl-1-piperidyl)-ethyl{9 -propionamide para-chlorobenzene sulfonate
    5.
    发明授权
    N-benzyl-N-{8 2-phenyl-2-(4-phenyl-1-piperidyl)-ethyl{9 -propionamide para-chlorobenzene sulfonate 失效
    N-苄基-N- {8 2-苯基-2-（4-苯基-1-哌啶基） - 乙基{9-丙酰胺对氯苯磺酸盐

    公开(公告)号：US3906100A

    公开(公告)日：1975-09-16

    申请号：US45745674

    申请日：1974-04-03

    Applicant: MILES LAB

    Inventor： HAVERA HERBERT JOHN

    IPC: A61K31/445

    CPC classification number: A61K31/445 ,  Y10S514/812

    Abstract: N-benzyl-N-(2-phenyl-2-(4-phenyl-1-piperidyl)ethyl)propionamide p-chlorobenzenesulfonate has effectiveness comparable to methadone in suppressing narcotic withdrawal symptoms and in maintenance therapy of narcotic addicted laboratory mammals.

    Abstract translation: N-苄基-N- [2-苯基-2-（4-苯基-1-哌啶基）乙基]丙酰胺对氯苯磺酸盐具有与美沙酮在抑制麻醉戒断症状和麻醉药上瘾实验室哺乳动物的维持治疗方面的效果相当。

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