公开(公告)号：US11613764B2

公开(公告)日：2023-03-28

申请号：US16512031

申请日：2019-07-15

申请人： MINK Therapeutics, Inc.

发明人： Marc van Dijk ,  Volker Seibert ,  Cornelia Anne Mundt ,  Arthur Andrew Hurwitz ,  Mark Adrian Exley ,  Benjamin Jacob Wolf ,  Daniel Leventhal ,  Sébastien Lalevée ,  Reed Masakayan

IPC分类号： C12N15/85 ,  A61K47/64 ,  C07K14/725 ,  C07K16/18 ,  A61K47/65 ,  C07K14/085 ,  C07K14/74

摘要： Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

公开(公告)号：US20240102044A1

公开(公告)日：2024-03-28

申请号：US18190954

申请日：2023-03-27

申请人： MiNK Therapeutics, Inc.

发明人： Marc van Dijk ,  Volker Seibert ,  Cornelia Anne Mundt ,  Arthur Andrew Hurwitz ,  Mark Adrian Exley ,  Benjamin Jacob Wolf ,  Daniel Leventhal ,  Sébastien Lalevée ,  Reed Masakayan

IPC分类号： C12N15/85 ,  A61K47/64 ,  A61K47/65 ,  C07K14/085 ,  C07K14/725 ,  C07K14/74 ,  C07K16/18

CPC分类号： C12N15/85 ,  A61K47/6425 ,  A61K47/65 ,  C07K14/085 ,  C07K14/7051 ,  C07K14/70539 ,  C07K16/18 ,  C07K2317/32 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2319/02

摘要： Provided are TCRs (e.g., TCRs that bind to NY-ESO-1), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

公开(公告)号：US20240301025A1

公开(公告)日：2024-09-12

申请号：US18340600

申请日：2023-06-23

申请人： MiNk Therapeutics, Inc.

发明人： Marc van Dijk ,  Ekaterina Vladimirovna Breous-Nystrom ,  Alessandra Franchino ,  Sébastien Lalevée ,  Arthur Andrew Hurwitz ,  Mark Adrian Exley ,  Benjamin Jacob Wolf

IPC分类号： C07K14/725 ,  A61K38/00 ,  A61K45/06 ,  C12N15/63

CPC分类号： C07K14/7051 ,  C12N15/63 ,  A61K38/00 ,  A61K45/06 ,  C07K2317/565

摘要： Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

公开(公告)号：US11718658B2

公开(公告)日：2023-08-08

申请号：US16807742

申请日：2020-03-03

申请人： MiNK Therapeutics, Inc.

发明人： Marc van Dijk ,  Ekaterina Vladimirovna Breous-Nystrom ,  Alessandra Franchino ,  Sébastien Lalevée ,  Arthur Andrew Hurwitz ,  Mark Adrian Exley ,  Benjamin Jacob Wolf

IPC分类号： C07K14/725 ,  C12N15/63 ,  A61K38/00 ,  A61K45/06

CPC分类号： C07K14/7051 ,  C12N15/63 ,  A61K38/00 ,  A61K45/06 ,  C07K2317/565

摘要： Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.