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公开(公告)号:US20220275360A1
公开(公告)日:2022-09-01
申请号:US17058124
申请日:2019-05-31
Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH
Inventor: Dong-Sik KIM , Mi Jung LEE , Mi Young OH , Hye-Ji CHOI , Gil-Jung KIM , Shin A JANG , Ae Rin YOON
Abstract: The present invention relates to a novel antibody library and an antibody-screening method using same. Having a human sequence-derived specific VH or VL scaffold, the antibody library according to the present invention exhibits high thermodynamic stability and enjoys the advantages of allowing high soluble expression as well as reversible folding. In addition, the antibody according to the present invention includes a variety of rationally controlled CDRs so as to exhibit high specificity and high affinity to all antigens and thus can be advantageously used for selecting an adequate candidate antibody against a target antigen.
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公开(公告)号:US20200317779A1
公开(公告)日:2020-10-08
申请号:US16754431
申请日:2018-10-22
Inventor: Ki Su KIM , Jun Hong JEONG , Ae Rin YOON , Eun Jung SONG , Hye Ji CHOI , Ok Jae LIM , Yun Jung LEE , Hyung Kwon LIM , Jong Wha WON
IPC: C07K16/28
Abstract: The present invention relates to an anti-CD3 antibody and a pharmaceutical composition for cancer treatment comprising same. The antibody according to the present invention has high affinity and specificity for CD3 and thus can be effectively used in cancer prevention or treatment.
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