公开(公告)号：US20220275360A1

公开(公告)日：2022-09-01

申请号：US17058124

申请日：2019-05-31

Applicant: MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH

Inventor： Dong-Sik KIM ,  Mi Jung LEE ,  Mi Young OH ,  Hye-Ji CHOI ,  Gil-Jung KIM ,  Shin A JANG ,  Ae Rin YOON

IPC: C12N15/10 ,  C07K16/00 ,  C07K16/28

Abstract: The present invention relates to a novel antibody library and an antibody-screening method using same. Having a human sequence-derived specific VH or VL scaffold, the antibody library according to the present invention exhibits high thermodynamic stability and enjoys the advantages of allowing high soluble expression as well as reversible folding. In addition, the antibody according to the present invention includes a variety of rationally controlled CDRs so as to exhibit high specificity and high affinity to all antigens and thus can be advantageously used for selecting an adequate candidate antibody against a target antigen.