公开(公告)号：US20170000878A1

公开(公告)日：2017-01-05

申请号：US15232736

申请日：2016-08-09

Applicant: MONASH UNIVERSITY

Inventor： Fasseli Joseph COULIBALY ,  Ashley Scott MANSELL ,  Rosemary Ann FFRENCH

IPC: A61K39/21 ,  A61K39/15 ,  C12N7/00

Abstract: A stable immunogenic or vaccine composition comprising a complex or polyhedra comprising same comprising an antigen of a pathogen or other antigen against which a immune response is sought in a human or non-human animal subject and a polyhedrin protein derived from a cytoplasmic polyhedrosis virus (CPV). Delivery of the complex to a subject in substantially polyhedral form induces an immune response thereto. Methods of using same to elicit an immune response.

Abstract translation: 一种稳定的免疫原性或疫苗组合物，其包含复合物或多面体，其包含在人或非人动物受试者中寻求免疫应答的病原体或其他抗原的抗原和衍生自细胞质多角体病毒（CPV）的多角体蛋白 ）。 复合物以基本上多面体形式递送到受试者，对其产生免疫应答。 使用它们引发免疫应答的方法。