公开(公告)号：US20160168251A1

公开(公告)日：2016-06-16

申请号：US14744087

申请日：2015-06-19

Applicant: MorphoSys AG

Inventor： Alisa WATERMAN ,  Daniel RAJOTTE ,  Tobias LITZENBURGER ,  Alexandra KRAUS

IPC: C07K16/28

CPC classification number: C07K16/2869 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/75 ,  C07K2317/92 ,  C07K2319/30

Abstract: Monoclonal antibodies that act as potentiators, stimulators and agonists of guanylyl cyclase receptors are disclosed.

Abstract translation: 公开了作为鸟苷酸环化酶受体的增强剂，刺激剂和激动剂的单克隆抗体。

公开(公告)号：US20150368323A1

公开(公告)日：2015-12-24

申请号：US14647459

申请日：2013-12-20

Applicant: MORPHOSYS AG

Inventor： Christoph Michael ERNST ,  Andreas Paul PESCHEL ,  Alexandra KRAUS ,  Michael TESAR

IPC: C07K16/12 ,  A61K38/12 ,  A61K39/40

CPC classification number: C07K16/1271 ,  A61K38/12 ,  A61K39/40 ,  A61K2039/505 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76

Abstract: This disclosure generally relates to antibodies or fragments thereof which interact with the bacterial protein MprF. The disclosure further discloses antibodies, which bind to specific extracellular motifs of MprF. The disclosure further relates to therapeutics comprising MprF-specific antibodies and methods of treatment using MprF-specific antibodies or fragments thereof.

Abstract translation: 本公开内容通常涉及与细菌蛋白MprF相互作用的抗体或其片段。 本公开进一步公开了结合MprF的特异性细胞外基序的抗体。 本公开还涉及包含MprF特异性抗体的治疗剂和使用MprF特异性抗体或其片段的治疗方法。

公开(公告)号：US20210024635A1

公开(公告)日：2021-01-28

申请号：US17069136

申请日：2020-10-13

Applicant: Immatics Biotechnologies GmbH ,  Morphosys AG

Inventor： Andrea MAHR ,  Toni WEINSCHENK ,  Dominik MAURER ,  Claudia WAGNER ,  Klaus Felix HARTLEPP ,  Alexandra KRAUS

IPC: C07K16/28 ,  C07K16/18 ,  G01N33/53 ,  C07K14/47 ,  G01N33/68

Abstract: The present invention relates to antibodies or fragments thereof binding to human WT1/HLA. In particular, the present invention relates to antibodies or fragments thereof that have combined improved and/or beneficial properties, and are therefore suited for clinical development.