公开(公告)号：US20150368323A1

公开(公告)日：2015-12-24

申请号：US14647459

申请日：2013-12-20

Applicant: MORPHOSYS AG

Inventor： Christoph Michael ERNST ,  Andreas Paul PESCHEL ,  Alexandra KRAUS ,  Michael TESAR

IPC: C07K16/12 ,  A61K38/12 ,  A61K39/40

CPC classification number: C07K16/1271 ,  A61K38/12 ,  A61K39/40 ,  A61K2039/505 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76

Abstract: This disclosure generally relates to antibodies or fragments thereof which interact with the bacterial protein MprF. The disclosure further discloses antibodies, which bind to specific extracellular motifs of MprF. The disclosure further relates to therapeutics comprising MprF-specific antibodies and methods of treatment using MprF-specific antibodies or fragments thereof.

Abstract translation: 本公开内容通常涉及与细菌蛋白MprF相互作用的抗体或其片段。 本公开进一步公开了结合MprF的特异性细胞外基序的抗体。 本公开还涉及包含MprF特异性抗体的治疗剂和使用MprF特异性抗体或其片段的治疗方法。