公开(公告)号：US3574132A

公开(公告)日：1971-04-06

申请号：US3574132D

申请日：1968-01-12

Applicant: MOSIER BENJAMIN ,  MICROCAP INC

Inventor： MOSIER BENJAMIN ,  TIPPETT CHARLES E

IPC: B01J13/10 ,  B01J13/02 ,  A01N17/00 ,  C23F11/14

CPC classification number: B01J13/10 ,  Y10S507/902 ,  Y10S507/92 ,  Y10S507/939 ,  Y10T428/2984

Abstract: PROCESS OF MICROENCAPSULATION EMPLOYING ALKALI-PRECURSOR (TYPE B) GELATIN AS THE ENCAPSULATING MACROCOLLOID, PARTICULARLY APPLICABLE TO THE FORMATION OF LIQUID CENTER MICROCAPSULES CONTAINING A BASIC (CATIONIC) NITROGEN COMPOUND. FOR EXAMPLE, AN AQUEOUS SOLUTION OF ALKALI-PRECURSOR GELATIN IS MIXED AT AN ALKALINE PH WITH A WATER-IMMISCIBLE ORGANIC SOLVENT SOLUTION OF A NITROGEN COMPOUND, SUCH AS AN AMINE OR A QUATERNARY. THE PH OF THE MIXTURE (VIZ, THE GELATIN PHASE) IS THEN REDUCED TO AT LEAST 4.5 AND PREFERABLY 3.8 OR BELOW, THE LIQUID PHASES BEING INTERMIXED TO DISPERSE AND EMULSIFY THE ORGANIC SOLVENT PHASE IN THE AQUEOUS PHASE, THEREBY PROVIDING MINUTE DROPLETS OF THE BASIC NITROGEN CONTAINING ORGANIC SOLVENT SURROUNDED BY THE AQUEOUS SOLUTION OF THE ALKALI-PRECURSOR GELATIN. AT THE LOW ACID PH, THE GELATIN FORMS A COATING ON THE DROPLETS AND PROVIDES ENCAPSULATING SKINS THEREFOR. WHILE THE ENCAPSULATED DROPLETS CAN BE RECOVERED AT THE LOW ACID PH, IT IS PREFERRED TO RAISE THE PH TO A PH ABOVE 5.5 (PREFERABLY 7.5-11), AND THEN RECOVER THE MICROCAPSULES. AN AUXILIARY COATING CAN BE APPLIED TO THE RECOVERED MICROCAPSULAR MATERIAL THUS PRODUCED BY CONTACTING THE MICROCAPSULES WITH AN AQUEOUS SOLUTION OF ACID-PRECURSOR GELATIN.

公开(公告)号：US3666678A

公开(公告)日：1972-05-30

申请号：US3666678D

申请日：1968-01-12

Applicant: MOSIER BENJAMIN

Inventor： MOSIER BENJAMIN ,  TIPPETT CHARLES E

IPC: A01N25/28 ,  B01J13/10 ,  C23F11/08 ,  B01J13/02 ,  A01N17/00 ,  C23F11/14

CPC classification number: A01N25/28 ,  B01J13/10 ,  C23F11/08 ,  Y10S507/902 ,  Y10S507/92 ,  Y10S507/939 ,  Y10T428/2984

Abstract: Process of microencapsulation employing acid precursor (type A) gelatin as the encapsulating macrocolloid, particularly applicable to the formation of liquid center microcapsules containing a basic (cationic) nitrogen compound. For example, an aqueous solution of acid-precursor gelatin is mixed at an alkaline pH with a water-immiscible organic solvent solution of the nitrogen compound, such as an amine or quaternary. The pH of the mixture and the gelatin phase is reduced to at least 4.0 and preferably 3.0 or below, the liquid phases being intermixed to disperse and emulsify the organic solvent phase in the aqueous phase, thereby providing minute droplets of the basic nitrogen containing organic solvent surrounded by the aqueous solution of the acid-precursor gelatin. On the completion of the pH reduction, the gelatin will have formed a coating around the individual droplets to provide encapsulating skins therefor. While the encapsulated droplets can be recovered with some success at the lowest acid pH, it is much preferred to raise the pH to a pH at least above 5.5 and preferably to an alkaline pH before recovering the microcapsules. An auxiliary coating can be applied to the recovered microcapsules by contacting them with an aqueous solution of alkali-precursor gelatin.

Abstract translation: 使用酸性前体（A型）明胶作为包封大胶体的微胶囊化方法，特别适用于形成含有碱性（阳离子）氮化合物的液体中心微胶囊。 例如，酸性前体明胶的水溶液在碱性pH下与氮化合物如胺或季铵的与水不混溶的有机溶剂溶液混合。 将混合物和明胶相的pH降低至至少4.0，优选3.0或更低，混合液相以在水相中分散和乳化有机溶剂相，从而提供含有碱性氮的有机溶剂的微滴 被酸 - 前体明胶的水溶液包围。 在pH降低完成后，明胶将在单个液滴周围形成涂层，以提供封装外观。 尽管可以在最低酸性pH下回收成套的胶囊，但是在回收微胶囊之前，将pH调节至至少高于5.5，优选将pH提高至碱性pH值是非常优选的。 通过将辅助涂层与碱前体明胶的水溶液接触，可将辅助涂层施加到回收的微胶囊上。