公开(公告)号：US20160317670A1

公开(公告)日：2016-11-03

申请号：US15107536

申请日：2015-01-14

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC分类号： A61K47/48 ,  A61K38/13 ,  A61K31/713 ,  A61K31/365 ,  A61K35/17 ,  C12N15/117 ,  A61K31/436 ,  A61K38/17

CPC分类号： C12N15/117 ,  A61K31/365 ,  A61K31/395 ,  A61K31/436 ,  A61K31/713 ,  A61K35/17 ,  A61K38/13 ,  A61K38/1793 ,  A61K38/2013 ,  A61K47/62 ,  A61K47/6909 ,  A61K2035/124 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2320/32

摘要： Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

摘要翻译： 公开了一种靶向C3分解产物，整联蛋白或其组合的纳米载体免疫抑制剂，以减少免疫抑制剂的有害全身效应。 还公开了抑制受试者中同种异体免疫应答的方法，例如可以在同种异体移植后发生的同种异体免疫应答。

公开(公告)号：US11214805B2

公开(公告)日：2022-01-04

申请号：US16548945

申请日：2019-08-23

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC分类号： A61K39/395 ,  C12N15/117 ,  A61K47/62 ,  A61K47/69 ,  A61K31/395 ,  A61K38/20 ,  C12N15/11 ,  A61K31/365 ,  A61K31/436 ,  A61K31/713 ,  A61K35/17 ,  A61K38/13 ,  A61K38/17 ,  A61K35/12

摘要： Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

公开(公告)号：US20200056183A1

公开(公告)日：2020-02-20

申请号：US16548945

申请日：2019-08-23

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC分类号： C12N15/117 ,  A61K38/17 ,  A61K38/13 ,  A61K35/17 ,  A61K31/713 ,  A61K31/436 ,  A61K31/365 ,  C12N15/11 ,  A61K38/20 ,  A61K31/395 ,  A61K47/69 ,  A61K47/62

摘要： Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.

公开(公告)号：US10428331B2

公开(公告)日：2019-10-01

申请号：US15107536

申请日：2015-01-14

申请人： MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

发明人： Ann-Marie Broome ,  Suraj Dixit ,  Satish Nadig ,  Carl Atkinson

IPC分类号： A61K39/395 ,  C12N15/117 ,  A61K31/365 ,  A61K31/436 ,  A61K31/713 ,  A61K35/17 ,  A61K38/13 ,  A61K38/17 ,  A61K38/20 ,  C12N15/11 ,  A61K31/395 ,  A61K47/62 ,  A61K47/69 ,  A61K35/12

摘要： Disclosed is a nanocarrier-containing immunosuppressive agent that is targeted to C3 breakdown products, integrin, or a combination thereof, to reduce the deleterious systemic effects of the immunosuppressive agent. Also disclosed is a method for suppressing an allo-immune response in a subject, such as one that can occur after an allograft transplantation.