公开(公告)号：US20230190930A1

公开(公告)日：2023-06-22

申请号：US17839029

申请日：2022-06-13

Applicant: MUSC Foundation for Research Development

Inventor： Daniel FERNANDES ,  Laura Schwartz ,  Natalie Sutkowski ,  Brian Hoel ,  Semyon Rubinchik

IPC: A61K39/395 ,  C07K16/18 ,  A61P35/00

CPC classification number: A61K39/395 ,  C07K16/18 ,  A61K39/3955 ,  A61P35/00 ,  C07K16/3015

Abstract: The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases.

公开(公告)号：US20160215050A1

公开(公告)日：2016-07-28

申请号：US14972698

申请日：2015-12-17

Applicant: MUSC Foundation for Research Development

Inventor： Natalie SUTKOWSKI ,  Daniel FERNANDES ,  Brian HOEL ,  Semyon RUBINCHIK

IPC: C07K16/28 ,  A61K47/48 ,  C07K16/30

CPC classification number: C07K16/28 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/303 ,  C07K16/3038 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/73 ,  C07K2317/734 ,  C07K2317/76

Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.

Abstract translation: 本发明提供了制备人核仁素的人单克隆抗体，产生这种抗体的细胞和抗体本身的方法。 还提供了使用抗体诊断和治疗恶性和非恶性疾病的方法，其中在细胞表面上表达核仁素的细胞有助于疾病的病理生理学。