公开(公告)号：US20230190930A1

公开(公告)日：2023-06-22

申请号：US17839029

申请日：2022-06-13

Applicant: MUSC Foundation for Research Development

Inventor： Daniel FERNANDES ,  Laura Schwartz ,  Natalie Sutkowski ,  Brian Hoel ,  Semyon Rubinchik

IPC: A61K39/395 ,  C07K16/18 ,  A61P35/00

CPC classification number: A61K39/395 ,  C07K16/18 ,  A61K39/3955 ,  A61P35/00 ,  C07K16/3015

Abstract: The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases.

公开(公告)号：US10385128B2

公开(公告)日：2019-08-20

申请号：US14972698

申请日：2015-12-17

Applicant: MUSC Foundation for Research Development

Inventor： Natalie Sutkowski ,  Daniel Fernandes ,  Brian Hoel ,  Semyon Rubinchik

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/18 ,  C07K16/30 ,  A61K47/68

Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.

公开(公告)号：US11357849B2

公开(公告)日：2022-06-14

申请号：US16080720

申请日：2017-03-07

Applicant: CharlestonPharma, LLC ,  MUSC Foundation for Research Development

Inventor： Daniel Fernandes ,  Laura Schwartz ,  Natalie Sutkowski ,  Brian Hoel ,  Semyon Rubinchik

IPC: A61K39/395 ,  C07K16/18 ,  A61P35/00 ,  C07K16/30 ,  C07K16/28 ,  A61K39/00 ,  A61K38/00

Abstract: The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases.

公开(公告)号：US20190382478A1

公开(公告)日：2019-12-19

申请号：US16454966

申请日：2019-06-27

Applicant: MUSC Foundation for Research Development

Inventor： Natalie Sutkowski ,  Daniel Fernandes ,  Brian Hoel ,  Semyon Rubinchik

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/18 ,  C07K16/30

Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.

公开(公告)号：US20190194334A1

公开(公告)日：2019-06-27

申请号：US16080720

申请日：2017-03-07

Applicant: CharlestonPharma, LLC ,  MUSC Foundation for Research Development

Inventor： Daniel Fernandes ,  Laura Schwarts ,  Natalie Sutkowski ,  Brian Hoel ,  Semyon Rubinchik

IPC: C07K16/28 ,  C07K16/30 ,  A61P35/00

CPC classification number: C07K16/2857 ,  A61K38/00 ,  A61K39/395 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73

Abstract: The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases.

公开(公告)号：US09709574B2

公开(公告)日：2017-07-18

申请号：US14205983

申请日：2014-03-12

Applicant: MUSC Foundation for Research Development

Inventor： Natalie Sutkowski ,  Semyon Rubinchik

IPC: C12N5/10 ,  C12N5/00 ,  C12N5/02 ,  G01N33/68 ,  C07K16/00 ,  C07K16/10 ,  C07K16/12 ,  C07K16/16 ,  C07K16/22 ,  C07K16/24 ,  C12N5/0781 ,  A61K39/00

CPC classification number: G01N33/6854 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/1018 ,  C07K16/1271 ,  C07K16/16 ,  C07K16/22 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/75 ,  C07K2317/92 ,  C12N5/0635 ,  C12N2510/04 ,  Y02A50/407

Abstract: The present invention provides for methods of producing human monoclonal antibodies against a wide variety of antigens including bacterial and viral antigens, as well as tumor antigens, and various autoantigens. Also provided are the antibodies themselves, nucleic acids encoding such antibodies, cells producing such antibodies, and methods of using such antibodies for diagnostic assays and passive immunity against disease states such as infection and cancer.

公开(公告)号：US20140275492A1

公开(公告)日：2014-09-18

申请号：US14205983

申请日：2014-03-12

Applicant: MUSC Foundation for Research Development

Inventor： Natalie SUTKOWSKI ,  Semyon Rubinchik

IPC: C07K16/10 ,  G01N33/68 ,  C12N5/0781

CPC classification number: G01N33/6854 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/1018 ,  C07K16/1271 ,  C07K16/16 ,  C07K16/22 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/75 ,  C07K2317/92 ,  C12N5/0635 ,  C12N2510/04 ,  Y02A50/407

Abstract: The present invention provides for methods of producing human monoclonal antibodies against a wide variety of antigens including bacterial and viral antigens, as well as tumor antigens, and various autoantigens. Also provided are the antibodies themselves, nucleic acids encoding such antibodies, cells producing such antibodies, and methods of using such antibodies for diagnostic assays and passive immunity against disease states such as infection and cancer.

Abstract translation: 本发明提供了针对各种抗原（包括细菌和病毒抗原以及肿瘤抗原以及各种自身抗原）产生人单克隆抗体的方法。 还提供了抗体本身，编码此类抗体的核酸，产生此类抗体的细胞，以及使用此类抗体进行诊断测定和针对疾病状态如感染和癌症的被动免疫的方法。