公开(公告)号：US11357849B2

公开(公告)日：2022-06-14

申请号：US16080720

申请日：2017-03-07

Applicant: CharlestonPharma, LLC ,  MUSC Foundation for Research Development

Inventor： Daniel Fernandes ,  Laura Schwartz ,  Natalie Sutkowski ,  Brian Hoel ,  Semyon Rubinchik

IPC: A61K39/395 ,  C07K16/18 ,  A61P35/00 ,  C07K16/30 ,  C07K16/28 ,  A61K39/00 ,  A61K38/00

Abstract: The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases.

公开(公告)号：US10385128B2

公开(公告)日：2019-08-20

申请号：US14972698

申请日：2015-12-17

Applicant: MUSC Foundation for Research Development

Inventor： Natalie Sutkowski ,  Daniel Fernandes ,  Brian Hoel ,  Semyon Rubinchik

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/18 ,  C07K16/30 ,  A61K47/68

Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.

公开(公告)号：US20190382478A1

公开(公告)日：2019-12-19

申请号：US16454966

申请日：2019-06-27

Applicant: MUSC Foundation for Research Development

Inventor： Natalie Sutkowski ,  Daniel Fernandes ,  Brian Hoel ,  Semyon Rubinchik

IPC: C07K16/28 ,  A61K47/68 ,  C07K16/18 ,  C07K16/30

Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.

公开(公告)号：US20190194334A1

公开(公告)日：2019-06-27

申请号：US16080720

申请日：2017-03-07

Applicant: CharlestonPharma, LLC ,  MUSC Foundation for Research Development

Inventor： Daniel Fernandes ,  Laura Schwarts ,  Natalie Sutkowski ,  Brian Hoel ,  Semyon Rubinchik

IPC: C07K16/28 ,  C07K16/30 ,  A61P35/00

CPC classification number: C07K16/2857 ,  A61K38/00 ,  A61K39/395 ,  A61K2039/505 ,  A61P35/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/3015 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73

Abstract: The present disclosure provides anti-nucleolin antibodies, methods of producing anti-nucleolin antibodies, and cells producing anti-nucleolin antibodies. Also provided are methods of using anti-nucleolin antibodies in treating malignant and non-malignant diseases.