公开(公告)号：US11938154B2

公开(公告)日：2024-03-26

申请号：US16959030

申请日：2019-02-27

Applicant: MUSC Foundation for Research Development

Inventor： Hongkuan Fan ,  Andrew Goodwin ,  Perry V. Halushka ,  James A Cook ,  Yue Zhou

IPC: A61K35/44 ,  A61K38/19 ,  A61P11/00 ,  A61P31/04

CPC classification number: A61K35/44 ,  A61K38/195 ,  A61P11/00 ,  A61P31/04

Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). The endothelial progenitor cell-derived exosomes can be modified to overexpress one or more miRNAs.