公开(公告)号：US20100048690A2

公开(公告)日：2010-02-25

申请号：US12304123

申请日：2007-06-15

申请人： Ma Jesus Martin Lopez ,  Laura Coello Molinero ,  Jose Fernando Reyes Benitez ,  Alberto Rodriguez Vicente ,  Maria Garranzo Garcia-Ibarrola ,  Carmen Murcia Perez ,  Andres Francesch Solloso ,  Francisco Sanchez Sancho ,  Maria del Carmen Cuevas Marchante ,  Rogelio Fernandez Rodriguez

发明人： Ma Jesus Martin Lopez ,  Laura Coello Molinero ,  Jose Fernando Reyes Benitez ,  Alberto Rodriguez Vicente ,  Maria Garranzo Garcia-Ibarrola ,  Carmen Murcia Perez ,  Andres Francesch Solloso ,  Francisco Sanchez Sancho ,  Maria del Carmen Cuevas Marchante ,  Rogelio Fernandez Rodriguez

IPC分类号： A61K31/351 ,  C07D309/30 ,  C12P17/06 ,  A61P35/00

CPC分类号： C07D309/32

摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.

摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。

公开(公告)号：US20090186938A1

公开(公告)日：2009-07-23

申请号：US12304123

申请日：2007-06-15

申请人： Ma Jesus Martin Lopez ,  Laura Coello Molinero ,  Jose Fernando Reyes Benitez ,  Alberto Rodriguez Vicente ,  Maria Garranzo Garcia-Ibarrola ,  Carmen Murcia Perez ,  Andres Francesch Solloso ,  Francisco Sanchez Sancho ,  Maria del Carmen Cuevas Marchante ,  Rogelio Fernandez Rodriguez

发明人： Ma Jesus Martin Lopez ,  Laura Coello Molinero ,  Jose Fernando Reyes Benitez ,  Alberto Rodriguez Vicente ,  Maria Garranzo Garcia-Ibarrola ,  Carmen Murcia Perez ,  Andres Francesch Solloso ,  Francisco Sanchez Sancho ,  Maria del Carmen Cuevas Marchante ,  Rogelio Fernandez Rodriguez

IPC分类号： A61K31/351 ,  C07D309/30 ,  C12P17/06 ,  A61P35/00

CPC分类号： C07D309/32

摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.

摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。

公开(公告)号：US20090030068A1

公开(公告)日：2009-01-29

申请号：US12097212

申请日：2006-12-14

申请人： Ma Jesus Martin Lopez ,  Jose Fernando Reyes Benitez ,  Rogelio Fernandez Rodriguez ,  Andres Francesch Solloso ,  Maria del Carmen Cuevas Marchante ,  Laura Coello Molinero

发明人： Ma Jesus Martin Lopez ,  Jose Fernando Reyes Benitez ,  Rogelio Fernandez Rodriguez ,  Andres Francesch Solloso ,  Maria del Carmen Cuevas Marchante ,  Laura Coello Molinero

IPC分类号： A61K31/335 ,  C07D323/00 ,  A61P35/00

CPC分类号： C07D493/18

摘要： The invention relates to novel antitumor compounds of general formula as well as their corresponding pharmaceutically acceptable salts, derivatives, prodrugs and stereoisomers. These compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. These compounds have cytotoxic activity and can be used for the treatment of the cancer.

摘要翻译： 本发明涉及通式的新型抗肿瘤化合物及其相应的药学上可接受的盐，衍生物，前药和立体异构体。 这些化合物可以通过从Theonellidae，Theonella属和swinhoei种分离海绵，并从分离的化合物形成衍生物获得。 这些化合物具有细胞毒性活性，可用于治疗癌症。