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公开(公告)号：US20100048690A2
公开(公告)日：2010-02-25
申请号：US12304123
申请日：2007-06-15
申请人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
发明人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
IPC分类号： A61K31/351 , C07D309/30 , C12P17/06 , A61P35/00
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号：US20090186938A1
公开(公告)日：2009-07-23
申请号：US12304123
申请日：2007-06-15
申请人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
发明人： Ma Jesus Martin Lopez , Laura Coello Molinero , Jose Fernando Reyes Benitez , Alberto Rodriguez Vicente , Maria Garranzo Garcia-Ibarrola , Carmen Murcia Perez , Andres Francesch Solloso , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernandez Rodriguez
IPC分类号： A61K31/351 , C07D309/30 , C12P17/06 , A61P35/00
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号：US20090030068A1
公开(公告)日：2009-01-29
申请号：US12097212
申请日：2006-12-14
申请人： Ma Jesus Martin Lopez , Jose Fernando Reyes Benitez , Rogelio Fernandez Rodriguez , Andres Francesch Solloso , Maria del Carmen Cuevas Marchante , Laura Coello Molinero
发明人： Ma Jesus Martin Lopez , Jose Fernando Reyes Benitez , Rogelio Fernandez Rodriguez , Andres Francesch Solloso , Maria del Carmen Cuevas Marchante , Laura Coello Molinero
IPC分类号： A61K31/335 , C07D323/00 , A61P35/00
CPC分类号： C07D493/18
摘要： The invention relates to novel antitumor compounds of general formula as well as their corresponding pharmaceutically acceptable salts, derivatives, prodrugs and stereoisomers. These compounds can be obtained by isolating a sponge from family Theonellidae, genus Theonella and species swinhoei, and forming derivatives from the isolated compounds. These compounds have cytotoxic activity and can be used for the treatment of the cancer.
摘要翻译： 本发明涉及通式的新型抗肿瘤化合物及其相应的药学上可接受的盐，衍生物，前药和立体异构体。 这些化合物可以通过从Theonellidae，Theonella属和swinhoei种分离海绵，并从分离的化合物形成衍生物获得。 这些化合物具有细胞毒性活性，可用于治疗癌症。
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公开(公告)号：US20120041063A2
公开(公告)日：2012-02-16
申请号：US12746966
申请日：2008-12-19
申请人： Alberto Rodriguez Vicente , Maria Garranzo Garcia- Ibarrola , Carmen Murcia Perez , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Cristina Mateo Urbano , Isabel Digon Juarez
发明人： Alberto Rodriguez Vicente , Maria Garranzo Garcia- Ibarrola , Carmen Murcia Perez , Francisco Sanchez Sancho , Maria del Carmen Cuevas Marchante , Cristina Mateo Urbano , Isabel Digon Juarez
IPC分类号： A61K31/216 , A61P35/00 , C07C229/36 , A61K31/165 , C07C237/52 , C07C271/12
CPC分类号： A61K31/695 , A61K31/351 , A61K31/366 , C07D309/10 , C07D309/30 , C07D309/32 , C07F7/1804 , Y02P20/55
摘要： A compound of general formula (I) wherein, R11, R12, R13, R14, R15, W, Y, R1, R2, R3, R4, R5, and R6 take various meanings for use in the treatment of cancer.
摘要翻译： 通式（I）的化合物，其中R11，R12，R13，R14，R15，W，Y，R1，R2，R3，R4，R5和R6具有用于治疗癌症的各种含义。
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公开(公告)号：US08501968B2
公开(公告)日：2013-08-06
申请号：US13171567
申请日：2011-06-29
申请人： Ma Jesús Martin López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
发明人： Ma Jesús Martin López , Laura Coello Molinero , José Fernando Reyes Benítez , Alberto Rodríguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Andrés Francesch Solloso , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Rogelio Fernández Rodríguez
IPC分类号： C07D309/30 , A01N43/16
CPC分类号： C07D309/32
摘要： Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided.
摘要翻译： 提供了从茯苓，蔷薇科，落叶松属，物种listoistoides及其衍生物获得的抗肿瘤化合物。
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公开(公告)号：US20110237520A1
公开(公告)日：2011-09-29
申请号：US13133359
申请日：2009-12-18
申请人： Laura Coello Molinero , Rogelio Fernández Rodriguez , José Fernando Reyes Benitez , Andrés Francesch Solloso , Maria del Carmen Cuevas Marchante
发明人： Laura Coello Molinero , Rogelio Fernández Rodriguez , José Fernando Reyes Benitez , Andrés Francesch Solloso , Maria del Carmen Cuevas Marchante
CPC分类号： C07K7/02
摘要： Compounds of general formula I: wherein R1-R15 and n take permitted meanings for use in the treatment of cancer.
摘要翻译： 通式I的化合物：其中R1-R15和n具有用于治疗癌症的允许含义。
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公开(公告)号：US20110034549A1
公开(公告)日：2011-02-10
申请号：US12746974
申请日：2008-12-19
申请人： Alberto Rodriguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Cristina Mateo Urbano , Isabel Digón Juárez
发明人： Alberto Rodriguez Vicente , María Garranzo García-Ibarrola , Carmen Murcia Pérez , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Cristina Mateo Urbano , Isabel Digón Juárez
IPC分类号： A61K31/351 , C07D315/00 , A61P35/00
CPC分类号： A61K31/695 , A61K31/351 , A61K31/366 , C07D309/10 , C07D309/30 , C07D309/32 , C07F7/1804 , Y02P20/55
摘要： A compound of general formula (I) wherein A, Y, W, R1, R2, R3, R4, R5, and R6 take various meanings for use in the treatment of cancer.
摘要翻译： 其中A，Y，W，R 1，R 2，R 3，R 4，R 5和R 6的通式（I）的化合物具有用于治疗癌症的各种含义。
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公开(公告)号：US20100280108A1
公开(公告)日：2010-11-04
申请号：US12746966
申请日：2008-12-19
申请人： Alberto Rodriguez Vicente , Maria Garranzo García-Ibarrola , Carmen Murcia Pérez , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Cristina Mateo Urbano , Isabel Digón Juárez
发明人： Alberto Rodriguez Vicente , Maria Garranzo García-Ibarrola , Carmen Murcia Pérez , Francisco Sánchez Sancho , Maria del Carmen Cuevas Marchante , Cristina Mateo Urbano , Isabel Digón Juárez
IPC分类号： A61K31/216 , C07C237/52 , C07C271/12 , C07C229/36 , A61K31/165 , A61P35/00
CPC分类号： A61K31/695 , A61K31/351 , A61K31/366 , C07D309/10 , C07D309/30 , C07D309/32 , C07F7/1804 , Y02P20/55
摘要： A compound of general formula (I) wherein, R11, R12, R13, R14, R15, W, Y, R1, R2, R3, R4, R5, and R6 take various meanings for use in the treatment of cancer.
摘要翻译： 通式（I）的化合物，其中R11，R12，R13，R14，R15，W，Y，R1，R2，R3，R4，R5和R6具有用于治疗癌症的各种含义。
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公开(公告)号：US20100216817A1
公开(公告)日：2010-08-26
申请号：US11913513
申请日：2006-05-03
申请人： José Fernando Reyes Benitez , Maria del Carmen Cuevas Marchante , David Montalvo Lobo , Maria-Jesús Martin López , Maria Cristina Mateo Urbano , Andrés Francesch Solloso
发明人： José Fernando Reyes Benitez , Maria del Carmen Cuevas Marchante , David Montalvo Lobo , Maria-Jesús Martin López , Maria Cristina Mateo Urbano , Andrés Francesch Solloso
IPC分类号： A61K31/505 , C07D239/06 , A61P35/00
CPC分类号： C07D239/06
摘要： Antitumoral compounds of the formula (I) wherein X is O, S, or NRa, obtained from a maze coral of the family Meandrinidae, genus Meandrina, species meandrites, or derivatives thereof are useful as antitumoral agents.
摘要翻译： 由Meandrinidae，Meandrina，Meandrina，或其衍生物的迷宫珊瑚获得的式（I）的式（I）的抗肿瘤化合物可用作抗肿瘤剂。
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公开(公告)号：US07683028B2
公开(公告)日：2010-03-23
申请号：US12019705
申请日：2008-01-25
摘要： The present invention is directed to new kahalalide antitumoral compounds, in particular to analogs of kahalalide F, useful as antitumoral, antiviral, and antifungal agents.
摘要翻译： 本发明涉及新的卡伐拉定抗肿瘤化合物，特别是可用作抗肿瘤剂，抗病毒剂和抗真菌剂的卡拉拉肽F的类似物。
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