公开(公告)号：US20220127220A1

公开(公告)日：2022-04-28

申请号：US17110567

申请日：2020-12-03

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Nanshan Zhong ,  Zifeng Yang ,  Jingrong Wang ,  Qitong Feng ,  Xiaobo Zhou ,  Beixian Zhou

IPC: C07C233/87

Abstract: A compound including a structure of Formula (I) and a preparation method thereof, wherein R1 is —OH, —CH2OH, or —OCOCH3; R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2, R3, and R4 is —F. A method for treating a subject suffering from a viral disease includes administering an effective amount of said compound or a solvate thereof to the subject.

公开(公告)号：US11377418B2

公开(公告)日：2022-07-05

申请号：US17110567

申请日：2020-12-03

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Nanshan Zhong ,  Zifeng Yang ,  Jingrong Wang ,  Qitong Feng ,  Xiaobo Zhou ,  Beixian Zhou

IPC: C07C233/87

Abstract: A compound including a structure of Formula (I) and a preparation method thereof, wherein R1 is —OH, —CH2OH, or —OCOCH3; R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2, R3, and R4 is —F. A method for treating a subject suffering from a viral disease includes administering an effective amount of said compound or a solvate thereof to the subject.