公开(公告)号：US20220088055A1

公开(公告)日：2022-03-24

申请号：US17094903

申请日：2020-11-11

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Lee-Fong Yau ,  Tian-Tian Tong ,  Hao Huang ,  Kua Hu ,  Elaine Lai-Han Leung

IPC: A61K31/7105 ,  A61P35/00 ,  A61K31/713 ,  C07K16/28

Abstract: This invention discloses a medicinal composition includes a non-coding RNA molecule and an antibody targeting a tumor antigen for preventing and/or treating cancer. This invention uses the synergistic combination of a non-coding RNA molecule or its functional variant or homologue, and an antibody targeting a tumor antigen to prevent and/or treat cancer, thereby providing a novel and effective method in preventing and/or treating various cancers.

公开(公告)号：US10900966B2

公开(公告)日：2021-01-26

申请号：US16281122

申请日：2019-02-21

Applicant: Macau University of Science and Technology

Inventor： Liang Liu ,  Jing-Rong Wang ,  Weina Gao ,  Leefong Yau ,  Hao Huang ,  Qiong Meng ,  Tiantian Tong ,  Zhi-Hong Jiang

IPC: G01N33/564 ,  G01N33/48 ,  G01N1/40 ,  G01N30/08 ,  G01N30/60 ,  B01L3/00 ,  G01N30/72 ,  G01N30/88

Abstract: The present invention discloses a method of determining the presence of autoimmune disease with the use of glycan biomarkers. A method of improving the detection sensitivity of trace glycans from a mixture of glycans and a microfluidic chip therefor are also disclosed.

公开(公告)号：US20170281702A1

公开(公告)日：2017-10-05

申请号：US15089687

申请日：2016-04-04

Applicant: Macau University of Science and Technology

Inventor： Jing-Rong Wang ,  Zhi-Hong Jiang ,  Qi-Tong Feng ,  Guo-Yuan Zhu ,  Wei-Na Gao ,  Zifeng Yang ,  Nanshan Zhong

IPC: A61K36/19 ,  A61K31/7056 ,  A61K31/192 ,  A61K31/404 ,  A61K31/047 ,  A61K31/191 ,  A61K31/538 ,  A61K31/517

CPC classification number: A61K36/19 ,  A61K31/404 ,  A61K31/538 ,  A61K31/567 ,  A61K2236/15 ,  A61K2236/17 ,  A61K2236/33 ,  A61K2236/55

Abstract: The present invention provides a method of isolating at least one ingredient with anti-viral efficacy from Baphicacanthus cusia. The ingredient can be an alkaloid, a triterpenoid, a lignan, a phenylethanoid, a sesquiterpene lactone, or a flavonoid. Two new alkaloids are produced, which have not been previously reported. Moreover, the method isolates 12 compounds which could not or have not been previously isolated. A pharmaceutical composition includes the at least one ingredient and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from a viral disease includes administering at least one ingredient isolated from Baphicacanthus cusia.

公开(公告)号：US11944636B2

公开(公告)日：2024-04-02

申请号：US17094903

申请日：2020-11-11

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Lee-Fong Yau ,  Tian-Tian Tong ,  Hao Huang ,  Kua Hu ,  Elaine Lai-Han Leung

IPC: C07H21/04 ,  A61K31/7105 ,  A61K31/713 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61P35/00 ,  C07K16/2818

Abstract: This invention discloses a medicinal composition includes a non-coding RNA molecule and an antibody targeting a tumor antigen for preventing and/or treating cancer. This invention uses the synergistic combination of a non-coding RNA molecule or its functional variant or homologue, and an antibody targeting a tumor antigen to prevent and/or treat cancer, thereby providing a novel and effective method in preventing and/or treating various cancers.

公开(公告)号：US20200071695A1

公开(公告)日：2020-03-05

申请号：US16120606

申请日：2018-09-04

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Tong-Meng Yan ,  Kai-Yue CAO

IPC: C12N15/113 ,  A61P35/00

Abstract: A method of treating a subject suffering from cancer includes administering an effective amount of a RNA molecule to the subject, wherein the RNA molecule is isolated or derived from a plant of the genus Taxus. A method of inhibiting growth or proliferation of cancer cells includes contacting cancer cells with the RNA molecule; and a pharmaceutical composition for treating cancer includes the RNA molecule and a pharmaceutically tolerable excipient. Also a double-stranded RNA molecule and a recombinant vector include the double-stranded RNA molecule.

公开(公告)号：US20170312266A1

公开(公告)日：2017-11-02

申请号：US15142373

申请日：2016-04-29

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Jing-Rong Wang ,  Cheng-Yu Chen ,  Guo-Yuan Zhu

IPC: A61K31/4745 ,  A61K36/24

CPC classification number: A61K31/4745 ,  A61K36/24

Abstract: A method of isolating at least one phenanthroindolizidine alkaloid, in particular with HIF-1 inhibitory activity, from Tylophora atrofolliculata is used to isolate and obtain for example about 22 phenanthroindolizidine alkaloids, including at least 11 new phenanthroindolizidine alkaloids which have not been previously isolated. Experimental tests confirmed an exceptional HIF-1 inhibitory activity of the phenanthroindolizidine alkaloids isolated. A pharmaceutical composition includes at least one phenanthroindolizidine alkaloid and at least one pharmaceutical tolerable excipient. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid isolated from Tylophora atrofolliculata. A method of treating a subject suffering from cancer includes administering at least one phenanthroindolizidine alkaloid to the subject.

公开(公告)号：US20220127220A1

公开(公告)日：2022-04-28

申请号：US17110567

申请日：2020-12-03

Applicant: Macau University of Science and Technology

Inventor： Zhi-Hong Jiang ,  Nanshan Zhong ,  Zifeng Yang ,  Jingrong Wang ,  Qitong Feng ,  Xiaobo Zhou ,  Beixian Zhou

IPC: C07C233/87

Abstract: A compound including a structure of Formula (I) and a preparation method thereof, wherein R1 is —OH, —CH2OH, or —OCOCH3; R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2, R3, and R4 is —F. A method for treating a subject suffering from a viral disease includes administering an effective amount of said compound or a solvate thereof to the subject.

公开(公告)号：US10260114B2

公开(公告)日：2019-04-16

申请号：US15598434

申请日：2017-05-18

Applicant: Southern Medical University ,  Macau University of Science and Technology

Inventor： Jin-Xiang Chen ,  Bin Sun ,  Bao-Ping Xie ,  Zhi-Hong Jiang ,  Li-Ping Bai

IPC: C07D213/50 ,  C12Q1/70 ,  C12Q1/6818 ,  C08G79/00

Abstract: The present invention relates in a first aspect to a method of preparing a crystalline lanthanum-carboxylate coordination polymer and the crystalline lanthanum-carboxylate coordination polymer obtained or obtainable by the method. In another aspect of the present invention, also provides a method of detecting a target nucleic acid sequence in a sample.

公开(公告)号：US10023594B2

公开(公告)日：2018-07-17

申请号：US15251300

申请日：2016-08-30

Applicant: Southern Medical University ,  Macau University of Science and Technology

Inventor： Jin-Xiang Chen ,  Bin Sun ,  Hai-Qing Zhao ,  Bao-Ping Xie ,  Li-Ping Bai ,  Zhi-Hong Jiang

IPC: C07F3/06 ,  C12Q1/70

Abstract: A method of preparing a crystalline zwitterionic zinc(II)-carboxylate compound includes the steps of preparing a mixture of zinc(II) ions and a first pyridyl ligand having three carboxylic acid moieties; subjecting the mixture to conditions under which a precipitate is formed; separating the precipitate; adding a solvent and optionally a second pyridyl ligand to the separated precipitate; subjecting the obtained mixture to conditions under which crystals of the zwitterionic zinc(II)-carboxylate compound are formed; and separating the crystals of the zwitterionic zinc(II)-carboxylate compound. Preferably but not exclusively, the crystalline zwitterionic zinc(II)-carboxylate compound essentially consists of at least one 1D coordination polymer. The compounds are suitable for providing a sensing platform for detecting the presence or amount of target nucleic acid, particularly HIV-1 ds-DNA, with specificity, and, thus, a method of detecting a target nucleic acid sequence in a sample and a kit including the compounds and an oligonucleotide probe are also provided.

公开(公告)号：US20180078660A1

公开(公告)日：2018-03-22

申请号：US15271368

申请日：2016-09-21

Applicant: Southern Medical University ,  Macau University of Science and Technology

Inventor： Jinxiang Chen ,  Jianxin Pang ,  Shuwen Liu ,  Li-Ping Bai ,  Zhi-Hong Jiang

IPC: A61K49/10 ,  C07D213/80

Abstract: A method of preparing a crystalline contrast agent for magnetic resonance imaging from a zwitterionic carboxylic pyridyl ligand includes mixing metal ion and the pyridyl ligand and obtaining crystals therefrom. The crystalline contrast agent includes a manganese-organic or gadolinium-organic 3D framework. The crystalline contrast agent is employed in a kit and a pharmaceutically acceptable composition. The method allows for preparing crystalline contrast agents with superior properties with easily available starting materials and with an economic and efficient process. The method allows for preparing crystalline contrast agents with exceptional water-stability and water-solubility, which exhibit high longitudinal relaxivities and with excellent stabilities under physiological conditions and low cytotoxicity. Further provided is a method for in vivo imaging of a subject, in particular a human, comprising administering the crystalline contrast agent to the subject.