公开(公告)号：US09895338B1

公开(公告)日：2018-02-20

申请号：US15242883

申请日：2016-08-22

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Man Chung Wong

IPC: A61K31/28 ,  A61K31/555 ,  A61K45/06

CPC classification number: A61K31/555 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.

公开(公告)号：US10369127B2

公开(公告)日：2019-08-06

申请号：US15632738

申请日：2017-06-26

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Man Chung Wong

IPC: A61K31/28 ,  A61K31/555 ,  A61K45/06

Abstract: A method for inhibiting the expression and/or functional activity of an ABC transporter protein in a subject suffering from a disorder associated with an overexpression of the ABC transporter protein includes administrating a cobalt-polypyridyl complex to the subject. A method for inhibiting the expression and/or functional activity of an ABC transporter in cells includes contacting the cells with an effective amount of the cobalt-polypyridyl complex.

公开(公告)号：US20180050045A1

公开(公告)日：2018-02-22

申请号：US15632738

申请日：2017-06-26

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Man Chung Wong

IPC: A61K31/555

CPC classification number: A61K31/28 ,  A61K31/555 ,  A61K45/06

Abstract: A method for inhibiting the expression and/or functional activity of an ABC transporter protein in a subject suffering from a disorder associated with an overexpression of the ABC transporter protein includes administrating a cobalt-polypyridyl complex to the subject. A method for inhibiting the expression and/or functional activity of an ABC transporter in cells includes contacting the cells with an effective amount of the cobalt-polypyridyl complex.

公开(公告)号：US20180050044A1

公开(公告)日：2018-02-22

申请号：US15242883

申请日：2016-08-22

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Man Chung Wong

IPC: A61K31/555 ,  A61K45/06

CPC classification number: A61K31/555 ,  A61K31/28 ,  A61K45/06 ,  A61K2300/00

Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.