公开(公告)号：US20100093870A1

公开(公告)日：2010-04-15

申请号：US12467383

申请日：2009-05-18

申请人： Madhur Ray ,  Raghwendra Pal ,  Satyawan Singh ,  Nandoo Mal Khanna

发明人： Madhur Ray ,  Raghwendra Pal ,  Satyawan Singh ,  Nandoo Mal Khanna

IPC分类号： A61K31/12 ,  A61P9/10

CPC分类号： A61K31/121 ,  A61K31/12 ,  A61K36/9066 ,  Y02A50/395 ,  A61K2300/00

摘要： The present invention relates to A composition obtained from the lipid soluble extract of rhizomes and leaves of Curcuma species of Zingiberaceae family, useful for the treatment of neurocerebrovascular disorders, said composition comprising fraction A consisting of ar-turmerone of formula 1, and turmerone of formula 2, and/or along with fraction B consisting of curcumene and zingiberine, and/or fraction C consisting of germacrone, curcumerone, zedoarone, sedoarondiol, isozdedoaronidiol, curcumenone, and curlone, and/or pharmaceutically acceptable additives and a method of treating neurocerebrovascular disorders in animals including humans using said composition by administering therapeutically effective amount of lipid soluble extract.

摘要翻译： 本发明涉及从根茎的脂溶性提取物和姜科科植物种的叶子获得的组合物，其可用于治疗神经性血管性疾病，所述组合物包含由式1的阿曲霉酮组成的级分A和式1的姜黄酮 和/或与由姜黄素和芝麻素组成的级分B和/或由克拉酮酮，姜黄酮，泽达隆，积雪草二烯，异喹硫醚，姜黄酮和卷曲酮组成的级分C和/或药学上可接受的添加剂和治疗神经性血管性血管病变的方法 在包括使用所述组合物的人的动物中，通过施用治疗有效量的脂溶性提取物。

公开(公告)号：US06991814B2

公开(公告)日：2006-01-31

申请号：US10319373

申请日：2002-12-13

申请人： Madhur Ray ,  Raghwendra Pal ,  Satyawan Singh ,  Nandoo Mal Khanna

发明人： Madhur Ray ,  Raghwendra Pal ,  Satyawan Singh ,  Nandoo Mal Khanna

IPC分类号： A61K35/78

CPC分类号： A61K31/121 ,  A61K31/12 ,  A61K36/9066 ,  A61K2300/00

摘要： The present invention relates to A composition obtained from the lipid soluble extract of rhizomes and leaves of Curcuma species of Zingiberaceae family, useful for the treatment of neurocerebrovascular disorders, said composition comprising fraction A consisting of ar-turmerone of formula 1, and turmerone of formula 2, and/or along with fraction B consisting of curcumene and zingiberine, and/or fraction C consisting of germacrone, curcumerone, zedoarone, sedoarondiol, isozdedoaronidiol, curcumenone, and curlone, and/or pharmaceutically acceptable additives and a method of treating neurocerebrovascular disorders in animals including humans using said composition by administering therapeutically effective amount of lipid soluble extract.

摘要翻译： 本发明涉及从根茎的脂溶性提取物和姜科科植物种的叶子获得的组合物，其可用于治疗神经性血管性疾病，所述组合物包含由式1的阿曲霉酮组成的级分A和式1的姜黄酮 和/或与由姜黄素和芝麻素组成的级分B和/或由克拉酮酮，姜黄酮，泽达隆，积雪草二烯，异喹硫醚，姜黄酮和卷曲酮组成的级分C和/或药学上可接受的添加剂和治疗神经性血管性血管病变的方法 在包括使用所述组合物的人的动物中，通过施用治疗有效量的脂溶性提取物。

公开(公告)号：US20060051438A1

公开(公告)日：2006-03-09

申请号：US11210567

申请日：2005-08-24

申请人： Madhur Ray ,  Raghwendra Pal ,  Satyawan Singh ,  Nandoo Khanna

发明人： Madhur Ray ,  Raghwendra Pal ,  Satyawan Singh ,  Nandoo Khanna

IPC分类号： A61K36/9066

CPC分类号： A61K31/121 ,  A61K31/12 ,  A61K36/9066 ,  Y02A50/395 ,  A61K2300/00

摘要： The present invention relates to A composition obtained from the lipid soluble extract of rhizomes and leaves of Curcuma species of Zingiberaceae family, useful for the treatment of neurocerebrovascular disorders, said composition comprising fraction A consisting of ar-turmerone of formula 1, and turmerone of formula 2, and/or along with fraction B consisting of curcumene and zingiberine, and/or fraction C consisting of germacrone, curcumerone, zedoarone, sedoarondiol, isozdedoaronidiol, curcumenone, and curlone, and/or pharmaceutically acceptable additives and a method of treating neurocerebrovascular disorders in animals including humans using said composition by administering therapeutically effective amount of lipid soluble extract.

公开(公告)号：US6150367A

公开(公告)日：2000-11-21

申请号：US954516

申请日：1997-10-20

申请人： Neelima Sinha ,  Sanjay Jain ,  Anil Kumar Saxena ,  Nitya Anand ,  Ram Mohan Saxena ,  Mangal Prasad Dubey ,  Madhur Ray ,  Gyanendra K. Patnaik, deceased

发明人： Neelima Sinha ,  Sanjay Jain ,  Anil Kumar Saxena ,  Nitya Anand ,  Ram Mohan Saxena ,  Mangal Prasad Dubey ,  Madhur Ray ,  Gyanendra K. Patnaik, deceased

IPC分类号： C07D207/26 ,  C07D207/27 ,  C07D211/76 ,  A61K31/496 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06

CPC分类号： C07D207/27 ,  C07D211/76

摘要： A chemical compound and composition of Formula 1: ##STR1## wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; said compounds and compositions as being useful therapeutic agents for hypertension, ischemic, cardiovascular and other adrenergic receptor related disorders.

摘要翻译： 式1的化合物和组合物：其中Ar表示被诸如卤素，烷氧基，烷基或杂芳基的基团取代的苯环，n = 1或n = 2; 所述化合物和组合物作为高血压，缺血性，心血管和其它肾上腺素能受体相关疾病的有用治疗剂。

公开(公告)号：US6084097A

公开(公告)日：2000-07-04

申请号：US960335

申请日：1997-10-29

申请人： Neelima Sinha ,  Sanjay Jain ,  Anil Kumar Saxena ,  Nitya Anand ,  Ram Mohan Saxena ,  Mangal Prasad Dubey ,  Madhur Ray ,  Gyanendra Kumar Patnaik, deceased

发明人： Neelima Sinha ,  Sanjay Jain ,  Anil Kumar Saxena ,  Nitya Anand ,  Ram Mohan Saxena ,  Mangal Prasad Dubey ,  Madhur Ray ,  Gyanendra Kumar Patnaik, deceased

IPC分类号： C07D207/26 ,  C07D207/27 ,  C07D211/76 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06

CPC分类号： C07D211/76 ,  C07D207/27

摘要： The invention relates to a process for the synthesis of 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes used as potential therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders, having general formula 1 ##STR1## wherein Ar represents a phenyl ring substituted by the groups like halo, alkoxy, alkyl or heteroaryl, n=1 or n=2; a process of preparing said compounds and a method of treating hypertension, ischemia, cardiovascular and other adrenergic receptors related disorders.

摘要翻译： 本发明涉及用作高血压，缺血，心血管和其他肾上腺素能潜在治疗剂的1- [4-芳基哌嗪-1-基] -3- [2-氧代吡咯烷/哌啶-1-基]丙烷的合成方法 受体相关疾病，具有通式1，其中Ar表示被诸如卤素，烷氧基，烷基或杂芳基的基团取代的苯环，n = 1或n = 2; 制备所述化合物的方法和治疗高血压，缺血，心血管和其它肾上腺素能受体相关疾病的方法。