公开(公告)号：US06953839B2

公开(公告)日：2005-10-11

申请号：US10830792

申请日：2004-04-23

申请人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： C07H21/04 ,  C07K14/315 ,  C12N1/21 ,  C07K14/00

CPC分类号： C07H21/04 ,  C07K14/315

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.

摘要翻译： 本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。 此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

公开(公告)号：US07544780B2

公开(公告)日：2009-06-09

申请号：US11800288

申请日：2007-05-04

申请人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： A61K38/17 ,  C07K14/00

CPC分类号： C07K14/78

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.

摘要翻译： 本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。 此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

公开(公告)号：US20100184085A1

公开(公告)日：2010-07-22

申请号：US12660596

申请日：2010-03-02

申请人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： G01N33/53 ,  C07K16/00 ,  C12N15/63 ,  C12N1/21 ,  C12P21/06

CPC分类号： C07K14/78

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.

摘要翻译： 本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。 此外，筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。

公开(公告)号：US07700731B2

公开(公告)日：2010-04-20

申请号：US12455840

申请日：2009-06-08

申请人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： A61K38/17 ,  C07K14/00

CPC分类号： C07K14/78

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.

摘要翻译： 本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。 此外，筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。

公开(公告)号：US07238783B2

公开(公告)日：2007-07-03

申请号：US11245689

申请日：2005-10-07

申请人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Höök ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： A61K38/17 ,  C07K14/00

CPC分类号： C07H21/04 ,  C07K14/315 ,  C07K14/78

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.

摘要翻译： 本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。 此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

公开(公告)号：US20090258390A1

公开(公告)日：2009-10-15

申请号：US12455840

申请日：2009-06-08

申请人： Magnus Hook ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Hook ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： C12P21/02 ,  C12N1/21 ,  C12N15/63 ,  G01N33/566 ,  C07K14/78 ,  C07K16/12

CPC分类号： C07K14/78

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of producing the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or integrin-interacting activities of recombinant collagen-like proteins.

摘要翻译： 本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。 此外，筛选抑制重组胶原样蛋白的整联蛋白结合或整联蛋白相互作用活性的潜在治疗化合物的方法。

公开(公告)号：US20080014613A1

公开(公告)日：2008-01-17

申请号：US11800288

申请日：2007-05-04

申请人： Magnus Hook ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Hook ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： C12P21/00 ,  C07K14/78 ,  C07K16/12 ,  C12N1/00 ,  G01N33/00 ,  C12N1/21 ,  C12N15/63

CPC分类号： C07K14/78

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.

摘要翻译： 本发明提供重组三螺旋蛋白或胶原样蛋白，其包含原核蛋白或原核蛋白的一个或多个结构域，其包含重复Gly-Xaa-Yaa三联体的胶原样肽序列和任选的一个或多个结构域 哺乳动物胶原蛋白。 还提供了含有表达载体以产生这些重组蛋白的表达载体和宿主细胞及其生产方法。 此外，提供针对重组胶原样蛋白的抗体，其优选结合整联蛋白。 此外，筛选抑制重组胶原样蛋白的整联蛋白结合或相互作用活性的潜在治疗化合物的方法。

公开(公告)号：US20060035336A1

公开(公告)日：2006-02-16

申请号：US11245689

申请日：2005-10-07

申请人： Magnus Hook ,  Slawomir Lukomski ,  Yi Xu

发明人： Magnus Hook ,  Slawomir Lukomski ,  Yi Xu

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N1/21

CPC分类号： C07H21/04 ,  C07K14/315 ,  C07K14/78

摘要： The present invention provides recombinant triple helical proteins or collagen-like proteins comprising a prokaryotic protein or one or more domains of a prokaryotic protein comprising a collagen-like peptide sequence of repeated Gly-Xaa-Yaa triplets and, optionally, one or more domains from a mammalian collagen. Also provided are expression vectors and host cells containing the expression vectors to produce these recombinant proteins and methods of production for the same. Additionally, antibodies are provided that are directed against a recombinant collagen-like protein that, preferably, binds an integrin. Furthermore, a method of screening for potential therapeutic compounds that inhibit the integrin-binding or -interacting activities of recombinant collagen-like proteins.

公开(公告)号：USD982064S1

公开(公告)日：2023-03-28

申请号：US29761532

申请日：2020-12-09

申请人： Yi Xu ,  Zhiquan Yang ,  Yonghui Yuan ,  Jieming Li ,  Sufan Peng

设计人： Yi Xu ,  Zhiquan Yang ,  Yonghui Yuan ,  Jieming Li ,  Sufan Peng

公开(公告)号：US08813690B2

公开(公告)日：2014-08-26

申请号：US12916872

申请日：2010-11-01

申请人： Shankar Kumar ,  Timothy R. Frazier ,  Donald W. Stanton ,  Yi Xu ,  Bruce G. Bunting ,  Leslie R. Wolf

发明人： Shankar Kumar ,  Timothy R. Frazier ,  Donald W. Stanton ,  Yi Xu ,  Bruce G. Bunting ,  Leslie R. Wolf

IPC分类号： F02B75/12

CPC分类号： F02D41/0025 ,  F02B3/06 ,  F02B29/0406 ,  F02D19/061 ,  F02D19/088 ,  F02D2041/1433 ,  F02D2200/0611 ,  F02M26/05 ,  F02M26/06 ,  F02M26/23 ,  Y02T10/36

摘要： A technique for engine control to account for fuel effects including providing an internal combustion engine and a controller to regulate operation thereof, the engine being operable to combust a fuel to produce an exhaust gas; establishing a plurality of fuel property inputs; establishing a plurality of engine performance inputs; generating engine control information as a function of the fuel property inputs and the engine performance inputs; and accessing the engine control information with the controller to regulate at least one engine operating parameter.

摘要翻译： 一种用于发动机控制以解决燃料效应的技术，包括提供内燃机和控制器以调节其操作，所述发动机可操作以燃烧燃料以产生废气; 建立多个燃料特性输入; 建立多个发动机性能输入; 根据燃料属性输入和发动机性能输入产生发动机控制信息; 以及利用所述控制器访问所述发动机控制信息以调节至少一个发动机操作参数。