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公开(公告)号：US08987297B2
公开(公告)日：2015-03-24
申请号：US14452652
申请日：2014-08-06
申请人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： A61K31/439 , A61K31/407 , A61K31/167 , C07D471/08 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/529 , A61K31/542 , A61K45/06
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
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公开(公告)号：US09132133B2
公开(公告)日：2015-09-15
申请号：US14609704
申请日：2015-01-30
申请人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： A61K31/439 , A61K31/5377 , C07D471/08 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/529 , A61K31/542 , A61K45/06 , A61K31/43 , A61K31/546
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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公开(公告)号：US20150174133A1
公开(公告)日：2015-06-25
申请号：US14609704
申请日：2015-01-30
申请人： Mahesh Vithalbhai PATEL , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai PATEL , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/43 , A61K31/427 , A61K31/407 , A61K31/439 , A61K31/546
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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公开(公告)号：US08853197B1
公开(公告)日：2014-10-07
申请号：US14294364
申请日：2014-06-03
申请人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： C07D471/08 , A61K31/542 , A61K31/529 , A61K31/429 , A61K45/06 , A61K31/407 , A61K31/496 , A61K31/167 , A61K31/427
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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公开(公告)号：US20140275018A1
公开(公告)日：2014-09-18
申请号：US14294364
申请日：2014-06-03
申请人： Mahesh Vithalbhai PATEL , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Snjeev Joshi
发明人： Mahesh Vithalbhai PATEL , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Snjeev Joshi
IPC分类号： C07D471/08
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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![1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections](/abs-image/US/2014/09/02/US08822450B2/abs.jpg.150x150.jpg)
6.发明授权1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections 有权1,6-二氮杂双环[3,2,1]辛-7-酮衍生物及其在细菌感染治疗中的应用公开(公告)号：US08822450B2
公开(公告)日：2014-09-02
申请号：US14111592
申请日：2012-08-24
申请人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawsar , Sachin Bhagwat , Mohammed Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawsar , Sachin Bhagwat , Mohammed Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： C07D471/08 , A61K31/542 , A61K31/529 , A61K31/429 , A61K45/06 , A61K31/407 , A61K31/496 , A61K31/167 , A61K31/427
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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![1,6- Diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections](/abs-image/US/2014/05/29/US20140148431A1/abs.jpg.150x150.jpg)
7.发明申请1,6- Diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections 有权1,6-二氮杂双环[3,2,1]辛-7-酮衍生物及其在细菌感染治疗中的应用公开(公告)号：US20140148431A1
公开(公告)日：2014-05-29
申请号：US14111592
申请日：2012-08-24
申请人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawsar , Sachin Bhagwat , Mohammed Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawsar , Sachin Bhagwat , Mohammed Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： A61K31/542 , A61K31/529 , A61K31/429 , A61K45/06 , A61K31/407 , A61K31/496 , A61K31/167 , C07D471/08 , A61K31/427
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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公开(公告)号：US20070219227A1
公开(公告)日：2007-09-20
申请号：US11715921
申请日：2007-03-09
申请人： Mahesh Patel , Vijaya Desai , Prasad Deshpande , Ravindra Yeole , Rajesh Kale
发明人： Mahesh Patel , Vijaya Desai , Prasad Deshpande , Ravindra Yeole , Rajesh Kale
IPC分类号： A61K31/4745 , C07D455/06
CPC分类号： C07D455/04
摘要： The instant invention relates to novel prodrugs of optically pure benzoquinolizine-2-carboxylic acid and pharmaceutical compositions that include the prodrugs. In particular, the present invention relates to the sulfonic acid salts of L-alanine and L-valine prodrugs of S-(−)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid. The compounds and compositions of the invention can be used to treat bacterial Gram-positive, Gram-negative and anaerobic infections, especially infections caused by resistant Gram-positive organism and Gram-negative organism, mycobacterial infections and emerging nosocomial pathogen infections.
摘要翻译： 本发明涉及光学纯苯醌喹唑啉-2-羧酸的新型前体药物和包含前药的药物组合物。 特别地，本发明涉及L-丙氨酸的磺酸盐和S - （ - ） - 9-氟-6,7-二氢-8-（4-羟基哌啶-1-基） - 5-甲基-1-氧代-1H，5H-苯并[i，j]喹嗪-2羧酸。 本发明的化合物和组合物可用于治疗细菌革兰氏阳性，革兰氏阴性和厌氧感染，特别是由抗性革兰氏阳性生物和革兰氏阴性生物，分枝杆菌感染和新出现的医院病原体感染引起的感染。
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