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1.发明授权Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor 有权包含β-内酰胺抗生素，舒巴坦和β-内酰胺酶抑制剂的药物组合物公开(公告)号：US09095594B2
公开(公告)日：2015-08-04
申请号：US14114207
申请日：2011-10-04
IPC分类号： A61K31/00 , A61K31/546 , A61K45/06 , A61K31/4188 , A61K31/424 , A61K31/43 , A61K31/431 , A61K31/439
CPC分类号： A61K31/546 , A61K31/4188 , A61K31/424 , A61K31/43 , A61K31/431 , A61K31/439 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions and methods for treating or preventing bacterial infections are disclosed. The pharmaceutical compositions typically comprise pharmaceutically effective amount of: (a) at least one beta-lactam antibiotic or a pharmaceutically acceptable salt thereof, (b) sulbactam or a pharmaceutically acceptable salt thereof, and (c) at least one beta-lactamase inhibitor or a pharmaceutically acceptable salt thereof, with the provision that the beta-lactamase inhibitor is not sulbactam.
摘要翻译： 公开了用于治疗或预防细菌感染的药物组合物和方法。 药物组合物通常包含药学有效量的：（a）至少一种β-内酰胺抗生素或其药学上可接受的盐，（b）舒巴坦或其药学上可接受的盐，和（c）至少一种β-内酰胺酶抑制剂或 其药学上可接受的盐，其条款是β-内酰胺酶抑制剂不是舒巴坦。
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![1,6- DIAZABICYCLO [3,2,1] OCTAN-7-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS](/abs-image/US/2015/07/23/US20150203503A1/abs.jpg.150x150.jpg)
2.发明申请1,6- DIAZABICYCLO [3,2,1] OCTAN-7-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF BACTERIAL INFECTIONS 审中-公开1,6-二氮杂双环[3,2,1] OCT-7-ONE衍生物及其在治疗细菌感染中的用途公开(公告)号：US20150203503A1
公开(公告)日：2015-07-23
申请号：US14365064
申请日：2013-04-19
申请人： Vijaykumar Jagdishwar Patil , Ravikumar Tadiparthi , Bharat Dond , Amol Kale , Loganathan Velupillai , Deepak Dekhane , Satish Shrimant Birajdar , Mohammad Usman Shaikh , Sushilkumar Maurya , Piyush Ambalal Patel , Prasad Dixit , Mangesh Pawar , Mahesh Vithalbhai Patel , Sachin Bhagwat
发明人： Vijaykumar Jagdishwar Patil , Ravikumar Tadiparthi , Bharat Dond , Amol Kale , Loganathan Velupillai , Deepak Dekhane , Satish Shrimant Birajdar , Mohammad Usman Shaikh , Sushilkumar Maurya , Piyush Ambalal Patel , Prasad Dixit , Mangesh Pawar , Mahesh Vithalbhai Patel , Sachin Bhagwat
IPC分类号： C07D487/08 , A61K45/06 , A61K31/55 , A61K31/496 , A61K31/439 , A61K31/4545
CPC分类号： C07D471/08 , A61K31/407 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/546 , A61K31/55 , A61K45/06 , A61P31/04 , C07C211/63 , C07D487/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed.
摘要翻译： 公开了式（I）化合物及其制备和用于预防或治疗细菌感染的方法。
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3.发明申请Pharmaceutical Compositions Comprising Beta-Lactam Antibiotic, Sulbactam and Beta-Lactamase Inhibitor 有权包含β-内酰胺抗生素，舒巴坦和β-内酰胺酶抑制剂的药物组合物公开(公告)号：US20140213566A1
公开(公告)日：2014-07-31
申请号：US14114207
申请日：2011-10-04
IPC分类号： A61K31/546 , A61K31/439 , A61K31/43
CPC分类号： A61K31/546 , A61K31/4188 , A61K31/424 , A61K31/43 , A61K31/431 , A61K31/439 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical compositions and methods for treating or preventing bacterial infections are disclosed. The pharmaceutical compositions typically comprise pharmaceutically effective amount of: (a) at least one beta-lactam antibiotic or a pharmaceutically acceptable salt thereof, (b) sulbactam or a pharmaceutically acceptable salt thereof, and (c) at least one beta-lactamase inhibitor or a pharmaceutically acceptable salt thereof, with the provision that the beta-lactamase inhibitor is not sulbactam.
摘要翻译： 公开了用于治疗或预防细菌感染的药物组合物和方法。 药物组合物通常包含药学有效量的：（a）至少一种β-内酰胺抗生素或其药学上可接受的盐，（b）舒巴坦或其药学上可接受的盐，和（c）至少一种β-内酰胺酶抑制剂或 其药学上可接受的盐，其条款是β-内酰胺酶抑制剂不是舒巴坦。
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公开(公告)号：US20140162995A1
公开(公告)日：2014-06-12
申请号：US14111627
申请日：2011-08-01
IPC分类号： A61K31/431 , A61K31/546
摘要： A pharmaceutical composition comprising antibacterial agent and tazobactam, wherein the ratio of tazobactam to the antibacterial agent in the composition is in the range of from about 0.5 to about 2 gram of tazobactam per gram of the antibacterial agent, are disclosed.
摘要翻译： 公开了包含抗菌剂和他唑巴坦的药物组合物，其中组合物中他唑巴坦与抗菌剂的比例为约0.5至约2克的他唑巴坦/克抗菌剂。
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公开(公告)号：US08288416B2
公开(公告)日：2012-10-16
申请号：US12311243
申请日：2007-09-22
申请人： Vijaykumar Jadgishwar Patil , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Deepak Vijaykumar Dekhane , Mohammad Usman Shaikh , Yati Chugh , Rajesh Prabhakar Chavan , Mohammad Alam Jafri
发明人： Vijaykumar Jadgishwar Patil , Mahesh Vithalbhai Patel , Bharat Kalidas Trivedi , Deepak Vijaykumar Dekhane , Mohammad Usman Shaikh , Yati Chugh , Rajesh Prabhakar Chavan , Mohammad Alam Jafri
IPC分类号： A61K31/445 , C07D413/14
CPC分类号： C07D413/10 , C07F9/65583
摘要： The present invention relates to oxazolidinones of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof. The invention also relates to processes for the preparation of the compound of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof, and to pharmaceutical compositions containing the compounds of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof and to methods for treating or preventing microbial infections using the compounds of Formula I and pharmaceutically acceptable salts, pharmaceutically acceptable solvates or polymorphs thereof.
摘要翻译： 本发明涉及式I的恶唑烷酮及其药学上可接受的盐，药学上可接受的溶剂化物或其多晶型物。 本发明还涉及制备式I化合物及其药学上可接受的盐，药学上可接受的溶剂合物或多晶型物的方法，以及含有式I化合物及其药学上可接受的盐，药学上可接受的溶剂化物或多晶型物的药物组合物，以及 使用式I化合物及其药学上可接受的盐，药学上可接受的溶剂合物或多晶型物治疗或预防微生物感染的方法。
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6.发明授权Polymorphs of racemic, dextrorotatory, and levorotatory enantioners of 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride and mesylate salts 有权1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基）-1,4-二氢-4-氧代 - 吡咯并[3,2-d] 喹啉-3-羧酸盐酸盐和甲磺酸盐公开(公告)号：US07538221B2
公开(公告)日：2009-05-26
申请号：US10578371
申请日：2004-11-10
申请人： Prasad Keshav Deshpande , Satish Baliram Bhavsar , Yati Chugh , Ravindra Dattatrya Yeole , Noel John De Souza , Mahesh Vithalbhai Patel
发明人： Prasad Keshav Deshpande , Satish Baliram Bhavsar , Yati Chugh , Ravindra Dattatrya Yeole , Noel John De Souza , Mahesh Vithalbhai Patel
IPC分类号： C07D215/38 , A61K31/44
CPC分类号： C07D401/04
摘要： A polymorphic forms of the hydrochloride salt and mesylate salt of racemic (±)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, dextrorotatory R-(+)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and S-(−)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid having formula (I) and (II) respectively are described. Processes for their preparation are also described. The invention further relates to methods of using, and pharmaceutical compositions comprising the compounds of the invention for treatment of bacterial infections in mammals.
摘要翻译： 外消旋（±）-1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基）-1,4-苯并二氢吡喃的盐酸盐和甲磺酸盐的多晶形式， -2,3-二氢-4-氧代 - 喹啉-3-羧酸，右旋R - （+）-1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基） - 1,4-二氢-4-氧代 - 喹啉-3-羧酸和S - （ - ） - 1-环丙基-6-氟-8-甲氧基-7-（4-氨基-3,3-二甲基哌啶-1-基） （I）和（II）的1,4-二氢-4-氧代 - 喹啉-3-羧酸。 还描述了其制备方法。 本发明还涉及包含本发明化合物用于治疗哺乳动物细菌感染的药物组合物的方法和药物组合物。
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公开(公告)号：US09744160B2
公开(公告)日：2017-08-29
申请号：US14112156
申请日：2011-10-04
IPC分类号： A61K31/424 , A61K31/439 , A61K31/4188 , A61K31/43 , A61K31/431
CPC分类号： A61K31/439 , A61K31/4188 , A61K31/424 , A61K31/43 , A61K31/431 , A61K2300/00
摘要： Pharmaceutical compositions and methods for treating or preventing bacterial infections are disclosed. The pharmaceutical compositions typically comprise pharmaceutically effective amount of: (a) sulbactam or a pharmaceutically acceptable salt thereof, and (b) at least one beta-lactamase inhibitor or a pharmaceutically acceptable salt thereof, with the provision that the beta-lactamase inhibitor is not sulbactam.
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公开(公告)号：US09132133B2
公开(公告)日：2015-09-15
申请号：US14609704
申请日：2015-01-30
申请人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai Patel , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： A61K31/439 , A61K31/5377 , C07D471/08 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/529 , A61K31/542 , A61K45/06 , A61K31/43 , A61K31/546
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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公开(公告)号：US20150174133A1
公开(公告)日：2015-06-25
申请号：US14609704
申请日：2015-01-30
申请人： Mahesh Vithalbhai PATEL , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
发明人： Mahesh Vithalbhai PATEL , Prasad Keshav Deshpande , Satish Bhawasar , Sachin Bhagwat , Mohammad Alam Jafri , Amit Mishra , Laxmikant Pavase , Sunil Gupta , Rajesh Kale , Sanjeev Joshi
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/43 , A61K31/427 , A61K31/407 , A61K31/439 , A61K31/546
CPC分类号： A61K31/5377 , A61K31/167 , A61K31/407 , A61K31/427 , A61K31/429 , A61K31/43 , A61K31/439 , A61K31/4545 , A61K31/496 , A61K31/529 , A61K31/542 , A61K31/546 , A61K45/06 , C07D471/08
摘要： Compounds of Formula (I), their preparation and use in preventing or treating bacterial infection is disclosed.
摘要翻译： 公开了式（I）化合物，其制备和用于预防或治疗细菌感染。
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公开(公告)号：US20130059774A1
公开(公告)日：2013-03-07
申请号：US13578428
申请日：2010-04-01
IPC分类号： A61K31/546 , A61K31/7048 , A61K31/65 , A61P31/00 , C12N1/10 , A61P31/10 , C12N1/20 , C12N1/14 , C12N1/16 , A61K38/12 , A61P31/04
CPC分类号： A61K31/546 , A61K31/65 , A61K31/7048 , A61K45/06 , A61K2300/00
摘要： Novel compositions and methods of reducing microbial resistance to antimicrobial agents and treating infections are disclosed. In particular, compositions and methods of inhibiting efflux pump activity, treating infection and methods of enhancing antimicrobial activity of antimicrobial agents are provided.
摘要翻译： 公开了降低微生物对抗微生物剂的抗性和治疗感染的新型组合物和方法。 特别地，提供抑制外排泵活性，治疗感染的组合物和方法以及增强抗微生物剂的抗微生物活性的方法。
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