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    Apparatus and method for transdermal delivery of epoetin-based agents
    2.
    发明申请
    Apparatus and method for transdermal delivery of epoetin-based agents 审中-公开
    用于透皮递送基于epoetin的药剂的装置和方法

    公开(公告)号：US20060182789A1

    公开(公告)日：2006-08-17

    申请号：US11355856

    申请日：2006-02-15

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    IPC分类号： A61K38/18 ,  A61F13/02 ,  A61M31/00

    CPC分类号： A61M37/0015 ,  A61K9/0021 ,  A61K9/06 ,  A61K38/1816 ,  A61M2037/0023 ,  A61M2037/0046

    摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, an Epoetin-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having an Epoetin-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the Epoetin-based agent is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于Epoetin的试剂包含在施加到微喷射构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括具有基于Epoetin的含药剂的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。 在替代实施方案中，基于Epoetin的试剂包含在涂层和水凝胶制剂中。

    Stable Therapeutic Formulations
    5.
    发明申请
    Stable Therapeutic Formulations 有权
    稳定的治疗配方

    公开(公告)号：US20070184096A1

    公开(公告)日：2007-08-09

    申请号：US11617639

    申请日：2006-12-28

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Scott Sellers ,  Yuh-Fun Maa

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Scott Sellers ,  Yuh-Fun Maa

    IPC分类号： A61K48/00 ,  A61K9/70 ,  A61K31/716

    CPC分类号： A61K9/0021 ,  A61K9/703 ,  A61K31/716 ,  A61K38/2242 ,  A61K38/29 ,  A61K48/00 ,  A61K2039/54 ,  A61M37/0015 ,  A61M2037/0023 ,  B65B7/02 ,  B65B31/00 ,  B65B51/10 ,  B65B55/00 ,  B65D81/20 ,  B65D81/266 ,  Y02A50/471 ,  Y02A50/478

    摘要： Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

    摘要翻译： 用于配制和递送具有增强的物理稳定性的生物活性剂制剂的组合物和方法，并且其中由氧和/或水的存在引起的劣化被最小化和/或控制，以产生稳定的制剂。 用于配制和递送本发明的生物活性剂的组合物和方法进一步促进它们掺入生物相容性涂层中，所述生物相容性涂层可用于涂覆角质层刺穿的微喷射体，或多个角质层刺穿的输送装置的微突出物 ，用于通过受试者的皮肤递送生物相容性涂层，从而提供递送生物活性剂的有效手段。

    Apparatus and method for transdermal delivery of fentanyl-based agents
    7.
    发明申请
    Apparatus and method for transdermal delivery of fentanyl-based agents 审中-公开
    用于透皮递送芬太尼基药剂的装置和方法

    公开(公告)号：US20050226922A1

    公开(公告)日：2005-10-13

    申请号：US11084636

    申请日：2005-03-18

    申请人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    发明人： Mahmoud Ameri ,  Michel Cormier ,  Yuh-Fun Maa ,  Peter Daddona

    IPC分类号： A61K9/70 ,  A61K31/445 ,  A61M37/00

    CPC分类号： A61K9/0021 ,  A61K31/445 ,  A61M37/0015 ,  A61M2037/0023

    摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the fentanyl-based agent is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a gel pack having a fentanyl-based agent-containing hydrogel formulation that is disposed on the microprojection member after application to the skin of a patient. In an alternative embodiment, the fentanyl-based agent is contained in both the coating and the hydrogel formulation.

    摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于芬太尼的药剂包含在施加到微突出物构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括具有含有基于芬太尼的药剂的水凝胶制剂的凝胶包，其在施用到患者皮肤之后设置在微突出物构件上。 在替代实施方案中，基于芬太尼的药剂包含在包衣和水凝胶制剂中。

    Compositions of stabilized DNA for coating microprojctions
    9.
    发明申请
    Compositions of stabilized DNA for coating microprojctions 审中-公开
    用于涂覆微孔的稳定化DNA的组成

    公开(公告)号：US20050090009A1

    公开(公告)日：2005-04-28

    申请号：US10972230

    申请日：2004-10-21

    申请人： Michel Cormier ,  Georg Widera ,  Mahmoud Ameri

    发明人： Michel Cormier ,  Georg Widera ,  Mahmoud Ameri

    IPC分类号： A61K48/00 ,  C12N15/89 ,  C12N15/87

    CPC分类号： A61K48/0008 ,  A61K48/0025 ,  A61K48/0041 ,  C12N15/89

    摘要： The present invention provides methods and compositions for stabilizing dried nucleic acids with carbohydrates such as non-reducing sugars, polysaccharides, and reducing sugars. Preferably, the stabilized nucleic acids are coated on a microprojection member for transdermal delivery. The invention further provides compositions and methods that involve the use of DNase inhibitors to stabilize dried nucleic acids delivered directly into bodily tissues.

    摘要翻译： 本发明提供了用碳水化合物如非还原糖，多糖和还原糖稳定干燥的核酸的方法和组合物。 优选地，将稳定的核酸涂覆在用于透皮递送的微突出物构件上。 本发明还提供涉及使用DNase抑制剂稳定直接递送到身体组织中的干燥核酸的组合物和方法。