公开(公告)号：US6144758A

公开(公告)日：2000-11-07

申请号：US581261

申请日：1995-12-29

申请人： Makito Fukushima ,  Yoshiko Shiimori ,  Shin Sato ,  Masato Some

发明人： Makito Fukushima ,  Yoshiko Shiimori ,  Shin Sato ,  Masato Some

IPC分类号： G01N21/17 ,  G06K9/00 ,  G06K9/32 ,  G06T1/00 ,  G06T7/00

CPC分类号： G06K9/00127 ,  G06K9/3233 ,  G06T7/0012

摘要： A biochemical image analyzing apparatus includes image data memory for storing image data of a biochemical image produced based on data obtained by converting to electrical signals locational information of regarding labeled substance contained in a sample produced by one-dimensionally distributing at least one specimen, a data processor for selecting image data from among the image data stored in the image data memory and processing the selected image data in a predetermined manner to produce display image data mapped in a planar coordinate system, a display for displaying an image based on the display image data, and a first image data divider for producing first divided coordinate data by dividing the display image data along one coordinate axis of the planar coordinate system to produce lanes defining regions to be quantified along the one coordinate axis. According to the thus constituted biochemical image analyzing apparatus, it is possible to quickly define regions of interest to be quantified or quantitatively analyzed in a biochemical image without requiring an operator to conduct complicated operations.

摘要翻译： 生物化学图像分析装置包括图像数据存储器，用于存储基于通过转换为电信号获得的数据而生成的生化图像的图像数据的位置信息，所述位置信息涉及通过一维分布至少一个样本产生的样品中包含的标记物质，数据 处理器，用于从存储在图像数据存储器中的图像数据中选择图像数据，并以预定方式处理所选择的图像数据，以产生映射在平面坐标系中的显示图像数据;基于显示图像数据显示图像的显示器 以及第一图像数据分割器，用于通过沿着平面坐标系的一个坐标轴划分显示图像数据来产生沿着一个​​坐标轴定义要量化的区域的通道来产生第一分割坐标数据。 根据这样构成的生化图像分析装置，可以在生化图像中快速定义要量化或定量分析的感兴趣区域，而不需要操作者进行复杂的操作。

公开(公告)号：US20130303389A1

公开(公告)日：2013-11-14

申请号：US13549961

申请日：2012-07-16

申请人： TAKASHI TAKAHASHI ,  Shuta Tomita ,  Tetsuya Mitsudomi ,  Yasushi Yatabe ,  Nobuhiko Ogura ,  Masato Some

发明人： TAKASHI TAKAHASHI ,  Shuta Tomita ,  Tetsuya Mitsudomi ,  Yasushi Yatabe ,  Nobuhiko Ogura ,  Masato Some

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene in lung cancer tissues isolated from the patient.

摘要翻译： 本发明提供一种确认基因表达的方法，该方法可用于决定患者肺癌的5年生存率，并在该方法中使用DNA探针试剂盒。 用于决定患有非小细胞肺癌的患者存活率的方法，其包括确认从患者分离的肺癌组织中至少一种基因的表达强度。

公开(公告)号：US20070031893A1

公开(公告)日：2007-02-08

申请号：US11496483

申请日：2006-08-01

申请人： Masato Some

发明人： Masato Some

IPC分类号： G06F19/00 ,  G01N33/53

CPC分类号： G01N33/54373 ,  G01N21/553

摘要： An object of the present invention is to provide a method for measuring a reaction rate coefficient in an analysis utilizing total reflection attenuation, which is capable of calculating the reaction rate coefficient speedily and accurately. The present invention provides a method for measuring adsorption rate coefficient (Ka) and diffusion coefficient (D) in a reaction between an analyte molecule immobilized on a metal surface and a molecule that interacts with the analyte molecule, by measuring an angular change in the total reflection attenuation angle (θSP) using an analysis device utilizing total reflection attenuation, which comprises (1) providing multiple simulation curves of a binding dissociation reaction for sets of variables in which adsorption rate coefficient (Ka) and diffusion coefficient (D) are each varied within a predetermined width, (2) preparing a measurement curve of the binding dissociation reaction based on an angular change in a measured total reflection attenuation angle (θSP), (3) examining the level of correspondence between the measurement curve prepared in above (2) and the multiple simulation curves of above (1), and (4) applying the adsorption rate coefficient (Ka) and diffusion coefficient (D) that were used for the preparation of the simulation curve with the highest level of correspondence to the adsorption rate coefficient (Ka) and the diffusion coefficient (D) in the reaction between the analyte molecule immobilized on the metal surface and the molecule that interacts with the analyte molecule.

摘要翻译： 本发明的目的是提供一种利用全反射衰减的分析中的反应速度系数的测定方法，其能够快速准确地计算反应速度系数。 本发明提供了一种测量固定在金属表面上的分析物分子与与分析物分子相互作用的分子之间的反应中的吸附速率系数（Ka）和扩散系数（D）的方法，通过测量总共的角度变化 使用全反射衰减的分析装置的反射衰减角（thetaSP），其包括（1）为吸附速率系数（Ka）和扩散系数（D）各自变化的变量组提供结合解离反应的多个模拟曲线 在预定宽度内，（2）基于所测量的全反射衰减角（thetaSP）中的角度变化来制备结合解离反应的测量曲线，（3）检查上述制备的测量曲线（2 ）和上述（1）的多个模拟曲线，（4）应用吸附速率系数（Ka）和扩散系数 用于制备与固定在金属表面上的分析物分子与分子之间的反应中的吸附速率系数（Ka）和扩散系数（D）对应的最高水平的模拟曲线的（f） 与分析物分子相互作用。

公开(公告)号：US06714669B2

公开(公告)日：2004-03-30

申请号：US09820868

申请日：2001-03-30

申请人： Masato Some

发明人： Masato Some

IPC分类号： G06K900

CPC分类号： G06T7/70 ,  G06T2207/30004

摘要： An image processing apparatus includes a temporary memory for two-dimensionally mapping and temporarily storing image data containing image region data corresponding to two image regions having a similar shape and stored in an image data memory, a CRT for reproducing images based on the image data stored in the temporary memory, an interest region defining section for defining a region of interest in one of the two image regions having a similar shape displayed on the CRT, a pixel specifying section for specifying a first reference pixel in the one of the two image regions having a similar shape and specifying a second pixel corresponding to the first reference pixel in one image region other than the one of two image regions, a copy section for copying the region of interest defined by the interest region defining section and the first reference pixel specified by the pixel specifying section, a template matching section for effecting template matching between minute region image data corresponding to a minute region containing the coordinate value of the first reference pixel as a center coordinate value and minute region image data corresponding to a minute region containing the coordinate value of the second reference pixel corresponding to the first reference pixel as a center coordinate value, and an affine conversion section for effecting an affine conversion on image data corresponding to an outer periphery of the region of interest stored in the temporary memory based on the result of the template. The thus constituted image processing apparatus can easily define image regions corresponding to each other in two images or image regions corresponding to each other in an image as regions of interest using the same figure.

摘要翻译： 图像处理装置包括用于二维地映射并临时存储包含对应于具有相似形状并且存储在图像数据存储器中的两个图像区域的图像区域数据的图像数据的临时存储器，用于基于存储的图像数据再现图像的CRT 在临时存储器中，用于定义在CRT上显示的类似形状的两个图像区域之一中的感兴趣区域的兴趣区域定义部分，用于指定两个图像区域之一中的第一参考像素的像素指定部分 具有类似的形状并且指定与两个图像区域中的一个不同的一个图像区域中的与第一参考像素对应的第二像素，复制部分，用于复制由兴趣区域定义部分定义的关注区域和指定的第一参考像素 通过像素指定部分，用于实现微小区域图像数据之间的模板匹配的模板匹配部分 对应于包含第一参考像素的坐标值作为中心坐标值的微小区域和对应于包含与第一参考像素对应的第二参考像素的坐标值作为中心坐标值的微小区域的微小区域图像数据， 以及仿射变换部分，用于基于模板的结果，对与存储在临时存储器中的感兴趣区域的外围相对应的图像数据进行仿射转换。 这样构成的图像处理装置可以使用相同的图来容易地将图像中的彼此对应的图像或图像区域中的图像区域定义为感兴趣区域。

公开(公告)号：US06996289B1

公开(公告)日：2006-02-07

申请号：US09639992

申请日：2000-08-16

申请人： Yasuhiro Tsutamori ,  Masato Some ,  Takumi Suzuki

发明人： Yasuhiro Tsutamori ,  Masato Some ,  Takumi Suzuki

IPC分类号： G06K9/40

CPC分类号： G06T5/005 ,  G06T5/20 ,  H04N1/401

摘要： A image processing apparatus includes an image data memory for storing digital image data obtained by photoelectrically detecting light with a CCD to produce analog image data and digitizing the analog pixel data, a window memory for two-dimensionally mapping and storing the digital image data stored in the image data memory, and an abnormal pixel determining section for specifying each pixel in the digital image data stored in the window memory as a subject pixel, reading the density signal level of the subject pixel together with the density signal levels of pixels adjacent to the subject pixel, comparing the density signal level of the subject pixel with the density signal levels of pixels adjacent to the subject pixel and defining the subject pixel as an abnormal pixel when difference between the density signal level of the subject pixel and the density signal levels of pixels adjacent to the subject pixel is greater than a predetermined level. According to the thus constituted image processing apparatus, it is possible remove specific dot-like black pixels and white pixels generated in an image produced based on image data obtained by digitizing analog image data produced using a CCD without affecting the entire image, thereby correcting the image.

摘要翻译： 一种图像处理装置包括：图像数据存储器，用于存储通过用CCD光电检测光获得的数字图像数据，以产生模拟图像数据和数字化模拟像素数据;窗口存储器，用于二维地映射和存储存储在 图像数据存储器和用于指定存储在窗口存储器中的数字图像数据中的每个像素作为主题像素的异常像素确定部分，与邻近的像素的像素的浓度信号电平一起读取对象像素的浓度信号电平 将被摄体像素的浓度信号电平与与被摄体像素相邻的像素的浓度信号电平进行比较，并将被摄体像素的浓度信号电平与密度信号电平之间的差分定义为异常像素 与被摄体像素相邻的像素大于预定水平。 根据这样构成的图像处理装置，可以基于通过使用CCD产生的模拟图像数据进行数字化而不影响整个图像而获得的图像中产生的图像中产生的特定点状黑色像素和白色像素，从而校正 图片。

公开(公告)号：US06415038B1

公开(公告)日：2002-07-02

申请号：US08433643

申请日：1995-05-04

申请人： Takashi Kaneko ,  Masato Some

发明人： Takashi Kaneko ,  Masato Some

IPC分类号： G06K900

CPC分类号： H04N1/407 ,  H04N5/32

摘要： An image analyzing apparatus for forming images on a CRT based on image data and effecting quantitative analysis includes an image density lower limit setting section for setting a lower limit value of image density, an image density upper limit setting section for setting an upper limit value of image density and an image area specifying section for specifying image areas having density equal to or higher than the lower limit value of image density set by the image density lower limit setting means and equal to or lower than the upper limit value of image density set by the image density upper limit setting means from among the images displayed on the CRT. According to the thus constituted image analyzing apparatus, it is possible to specify a desired image area and quantitatively analyze the image area.

摘要翻译： 一种用于基于图像数据在CRT上形成图像并进行定量分析的图像分析装置包括用于设置图像浓度的下限值的图像浓度下限设定部分，用于设定图像浓度的上限值的图像浓度上限设定部分 图像浓度和图像区域确定部分，用于指定浓度等于或高于由图像浓度下限设定装置设置的图像浓度的下限值的图像区域，并且等于或低于由图像浓度设置的图像浓度设置的图像浓度的上限值 从显示在CRT上的图像中的图像浓度上限设定装置。 根据这样构成的图像分析装置，能够指定期望的图像区域并定量分析图像区域。

公开(公告)号：US06236744B1

公开(公告)日：2001-05-22

申请号：US08399465

申请日：1995-03-07

申请人： Masato Some ,  Takashi Kaneko

发明人： Masato Some ,  Takashi Kaneko

IPC分类号： G06K900

CPC分类号： G06T11/60

摘要： An image forming apparatus includes image data memory for storing image data, an image displaying section for displaying an image on a CRT, a graphic data memory for storing graphic data corresponding to patterns for defining regions of interest in the image on the CRT and a synthesized data producing section for synthesizing the image data and the graphic data to produce synthesized data, the image displaying section being adapted to display the image and pattern on the CRT based on the synthesized data. The apparatus further includes a pattern selecting section for selecting graphic data corresponding to the patterns for defining the regions of interest from among the graphic data stored in the graphic data memory, an editing mode determining section for determining an editing mode for editing the pattern corresponding to the selected graphic data, a graphic data editing section for editing the selected graphic data based on the determined editing mode, and edited graphic data producing section for producing edited graphic data based on the result of the editing of the graphic data editing section, the synthesized data producing section being adapted to produce synthesized data by synthesizing the image data, the graphic data and/or the edited graphic data. According to the thus constituted apparatus, it is possible to surround an area in the image displayed on the CRT by a pattern to specify a region of interest in a desired manner with a memory having a small capacity.

摘要翻译： 图像形成装置包括用于存储图像数据的图像数据存储器，用于在CRT上显示图像的图像显示部分，用于存储对应于CRT上的图像中关注区域的图案的图形数据的图形数据存储器， 数据产生部分，用于合成图像数据和图形数据以产生合成数据，图像显示部分适于基于合成数据在CRT上显示图像和图案。 该装置还包括一个图形选择部分，用于从存储在图形数据存储器中的图形数据中选择与用于定义感兴趣区域的图案相对应的图形数据;编辑模式确定部分，用于确定编辑对应于 所选择的图形数据，用于基于所确定的编辑模式编辑所选择的图形数据的图形数据编辑部分，以及用于根据图形数据编辑部分的编辑结果产生编辑图形数据的编辑图形数据产生部分，合成的 数据产生部分适于通过合成图像数据，图形数据和/或编辑的图形数据来产生合成数据。 根据这样构成的装置，可以通过图案来包围显示在CRT上的图像中的区域，以期望的方式用具有小容量的存储器指定感兴趣的区域。

公开(公告)号：US08244478B2

公开(公告)日：2012-08-14

申请号：US12942770

申请日：2010-11-09

申请人： Takashi Takahashi ,  Shuta Tomita ,  Tetsuya Mitsudomi ,  Yasushi Yatabe ,  Nobuhiko Ogura ,  Masato Some

发明人： Takashi Takahashi ,  Shuta Tomita ,  Tetsuya Mitsudomi ,  Yasushi Yatabe ,  Nobuhiko Ogura ,  Masato Some

IPC分类号： G06F7/00

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene in lung cancer tissues isolated from the patient.

摘要翻译： 本发明提供一种确认基因表达的方法，该方法可用于决定患者肺癌的5年生存率，并在该方法中使用DNA探针试剂盒。 用于决定患有非小细胞肺癌的患者存活率的方法，其包括确认从患者分离的肺癌组织中至少一种基因的表达强度。

公开(公告)号：US06937282B1

公开(公告)日：2005-08-30

申请号：US09415201

申请日：1999-10-12

申请人： Masato Some ,  Seishi Ikami

发明人： Masato Some ,  Seishi Ikami

IPC分类号： H04N5/228 ,  G06T5/00 ,  H04N1/40 ,  H04N5/225

CPC分类号： G06T5/006 ,  H04N5/217

摘要： A method and an apparatus for correcting influences of a distortion aberration of a lens in an image formed on an image surface by the lens. Distortions of respective portions of the image are corrected according to a distortion aberration characteristic of the lens. The distortion aberration characteristic indicates distortions at respective distances from an optical axis of the lens on the image surface. Then, a value of at least one kind of information belonging to each point of the image in which the distortions are corrected is determined based on values of the at least one kind of information belonging to points around a corresponding point in the image before the correction. Further, the density or brightness values of the predetermined pixels after the correction of the positions may be further corrected in consideration of the change of areas due to the distortion of the image.

摘要翻译： 一种用于校正由透镜在图像表面上形成的图像中的透镜的畸变像差的影响的方法和装置。 根据透镜的畸变像差特性校正图像的各部分的变形。 畸变像差特性表示在与图像表面上的透镜的光轴相距的距离处的失真。 然后，基于校正前的图像中的对应点周围的点的至少一种信息的值来确定属于图像的每个点的至少一种类型的信息，其中纠正失真的值 。 此外，考虑到由于图像的失真引起的区域的变化，可以进一步校正校正位置之后的预定像素的浓度或亮度值。

公开(公告)号：US20050170386A1

公开(公告)日：2005-08-04

申请号：US11008265

申请日：2004-12-10

申请人： Takashi Takahashi ,  Shuta Tomita ,  Tetsuya Mitsudomi ,  Yasushi Yatabe ,  Nobuhiko Ogura ,  Masato Some

发明人： Takashi Takahashi ,  Shuta Tomita ,  Tetsuya Mitsudomi ,  Yasushi Yatabe ,  Nobuhiko Ogura ,  Masato Some

IPC分类号： C12N15/09 ,  C12Q1/68 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158

摘要： The present invention provides a method of confirming the gene expression, useful in the decision of a five year survival rate of a patient with lung cancer and the use of a DNA probe kit in the method. A method useful in the decision of a survival rate of a patient with non-small cell lung cancer comprising confirming the expression strength of at least one gene selected from the group consisting of in lung cancer tissues isolated from the patient.

摘要翻译： 本发明提供一种确认基因表达的方法，该方法可用于决定患者肺癌的5年生存率，并在该方法中使用DNA探针试剂盒。 一种用于决定非小细胞肺癌患者的存活率的方法，其包括确认从患者分离的肺癌组织中选出的至少一种基因的表达强度。