公开(公告)号：US5929057A

公开(公告)日：1999-07-27

申请号：US92143

申请日：1998-06-05

申请人： Makoto Makishima ,  Yasuhiro Kanatani ,  Yoshio Honma ,  Kohei Inomata ,  Takao Kishiye

发明人： Makoto Makishima ,  Yasuhiro Kanatani ,  Yoshio Honma ,  Kohei Inomata ,  Takao Kishiye

IPC分类号： A61K31/355 ,  A61K31/59 ,  A61K31/20

CPC分类号： A61K31/355 ,  A61K31/59

摘要： 9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid.

摘要翻译： 提供9-顺式视黄酸-α-生育酚酯，含有该组合物的药物组合物，以及用于治疗白血病药物，特别是白血病缓解的药物组合物，并结合使用9-顺式 - 视黄酸-α-生育酚酯和1α，25-二羟基维生素D3或9-顺式 - 视黄酸在治疗白血病中表现出协同效应，而没有由1α，25-二羟基维生素D 3或9-顺式 - 视黄酸引起的任何副作用， 视黄酸。

公开(公告)号：US5827878A

公开(公告)日：1998-10-27

申请号：US884040

申请日：1997-06-27

申请人： Makoto Makishima ,  Yasuhiro Kanatani ,  Yoshio Honma ,  Kohei Inomata ,  Takao Kishiye

发明人： Makoto Makishima ,  Yasuhiro Kanatani ,  Yoshio Honma ,  Kohei Inomata ,  Takao Kishiye

IPC分类号： A61K31/355 ,  A61K31/59

CPC分类号： A61K31/355 ,  A61K31/59

摘要： 9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D.sub.3 or 9-cis-retinoic acid.

公开(公告)号：US6011069A

公开(公告)日：2000-01-04

申请号：US767624

申请日：1996-12-17

申请人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

发明人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

IPC分类号： A61K31/137 ,  A01N33/02

CPC分类号： A61K31/137

摘要： There is disclosed a multidrug resistance inhibitor for overcoming a multidrug resistance of cancer, or an agent for enhancing the activity of anti-cancer agents, which comprises as an active ingredient a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein n is an integer of 5 to 12,R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen, and/or by methylenedioxy, with the proviso that R.sub.1 and R.sub.2 are simultaneously not a compound of formula (II) ##STR2##

摘要翻译： 公开了用于克服癌症的多药耐药性的多药耐药性抑制剂或增强抗癌剂活性的药剂，其包含作为活性成分的式（I）化合物或其药学上可接受的盐：其中n 为5〜12的整数，R 1和R 2各自独立地为苄基，其中苯环可被1〜5个选自羟基，（C 1 -C 4）烷基，（C 1 -C 4）烷氧基和卤素的取代基取代， /或亚甲二氧基，条件是R1和R2不是式（II）的化合物，

公开(公告)号：US5756475A

公开(公告)日：1998-05-26

申请号：US791165

申请日：1997-01-30

申请人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

发明人： Kohei Inomata ,  Toshihiro Takahashi ,  Hitoshi Inoue ,  Makoto Yanai ,  Hiroyuki Yamazaki ,  Masashi Suzuki ,  Tsutomu Takasawa ,  Kouji Kawamura ,  Norio Oshida ,  Hiroyuki Ikemoto ,  Takao Kishiye

IPC分类号： C07C211/29 ,  C07C217/58 ,  C07D207/14 ,  C07D295/13 ,  C07D498/08 ,  A01N43/04 ,  A01N33/02 ,  C07C211/00

CPC分类号： C07D295/13 ,  C07C211/29 ,  C07C217/58 ,  C07D207/14 ,  C07C2101/04 ,  C07C2103/18 ,  Y10S514/937 ,  Y10S514/938

摘要： Isoprene derivatives of formula (I) ##STR1## wherein m is an integer of 0 to 3, n is an integer of 5 to 12, A is cyclo(C.sub.3 -C.sub.6)alkylene, phenylene, fluorenylene, pyrrolidinylene, piperazinylene, 9-aza-3-oxabicyclo�3.3.1!-nonylene, R.sub.1 and R.sub.2 are each independently benzyl, of which a phenyl ring may be substituted by 1 to 5 substituents selected from the group consisting of hydroxy, (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy and halogen, X is a single bond or a divalent radical of --(CH.sub.2).sub.p NH--, p is an integer of 0 to 3, or a pharmaceutically acceptable salt thereof. Those compounds are useful as multidrug resistance inhibitors for overcoming multidrug resistance of cancer and agents for enhancing an activity of anti-cancer agents.

摘要翻译： 式（I）的异戊二烯衍生物其中m为0〜3的整数，n为5〜12的整数，A为环（C 3〜C 6）亚烷基，亚苯基，亚芴基，吡咯烷基， 9-氮杂-3-氧杂双环[3.3.1] - 亚芳基，R 1和R 2各自独立地为苄基，其中苯环可被1至5个选自羟基，（C 1 -C 4）烷基 ，（C1-C4）烷氧基和卤素，X是 - （CH2）pNH-的单键或二价基团，p是0-3的整数，或其药学上可接受的盐。 那些化合物可用作克服癌症多药耐药性和增强抗癌药活性的药物的多药耐药性抑制剂。

公开(公告)号：US4829082A

公开(公告)日：1989-05-09

申请号：US902299

申请日：1986-08-29

申请人： Hiroshi Shinkai ,  Takao Kishiye

发明人： Hiroshi Shinkai ,  Takao Kishiye

IPC分类号： C07D311/72 ,  A61K31/352 ,  A61K31/355 ,  A61P17/00

CPC分类号： A61K31/355 ,  Y10S514/928

摘要： This invention relates to pharmaceutical compositions for the treatment of skin diseases which comprises as an active ingredient vitamin A esters of .alpha.-tocopherol.