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公开(公告)号:US20120149903A1
公开(公告)日:2012-06-14
申请号:US13325594
申请日:2011-12-14
IPC分类号: C07D403/12 , C07C231/10 , B01D3/36 , C07C209/68 , C07D401/14 , C07F9/6584 , C07C213/02 , C07C303/02
CPC分类号: C07C213/02 , C07C211/27 , C07C213/10 , C07C235/08 , C07D239/545 , C07D401/12 , C07D401/14 , C07F9/65846 , C07C215/08
摘要: The present invention relates to a process for purifying a reaction output which comprises 3-aminopropanol and is obtained in the reaction of ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises distilling the reaction output comprising 3-aminopropanol in two or more stages, the ammonia content of the reaction output comprising 3-aminopropanol before introduction into the first distillation stage being 1% by weight or less and the temperature in the distillation stages being not more than 135° C.The invention further relates to a process for preparing 3-aminopropanol by reacting ethylene cyanohydrin with hydrogen in the presence of ammonia, which comprises performing the purification of the reaction output comprising 3-aminopropanol in accordance with the invention. The present invention further provides a process for preparing 3-aminopropanol derivatives, especially panthenol, acambrosate, mefenorex, domperidon, ifosamid or urapidil, from 3-amino-propanol prepared in accordance with the invention.
摘要翻译: 本发明涉及一种纯化反应产物的方法,该方法包括3-氨基丙醇,并且在氨存在下在乙烯氰醇与氢气的反应中获得,其包括在两个或多个阶段蒸馏出包含3-氨基丙醇的反应产物, 在引入第一蒸馏阶段之前,包含3-氨基丙醇的反应产物的氨含量为1重量%以下,蒸馏阶段的温度不超过135℃。本发明还涉及制备3 - 氨基丙醇,其通过在氨的存在下使乙烯氰醇与氢气反应,其包括进行根据本发明的包含3-氨基丙醇的反应产物的纯化。 本发明还提供了一种由根据本发明制备的3-氨基丙醇制备3-氨基丙醇衍生物,特别是由3-氨基丙醇制备的泛醇,丙酸酯,甲氟醚,多西他顿,异头amid苷或乌拉地尔的方法。