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1.发明授权Pancreatin and method for reducing the viral and microbial contamination of pancreatin 有权胰蛋白酶和减少胰腺炎病毒和微生物污染的方法公开(公告)号：US08283147B2
公开(公告)日：2012-10-09
申请号：US12403697
申请日：2009-03-13
IPC分类号： C12N9/94
CPC分类号： C12N9/94 , A61L2/0023
摘要： The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.
摘要翻译： 本发明涉及一种生产具有减少的病毒和微生物污染的胰酶的方法，其包括以下步骤：（a）基于所提供的胰酶，提供固体形式的胰酶，残留水分为0.5重量％或更少，至少几乎为零 ; （b）使步骤（a）中提供的胰酶在84℃，优选80℃及以下的温度下进行热处理; 其中，步骤（b）中获得的胰酶的生物活性对应于步骤（a）中提供的胰酶的生物活性的至少50％。 与步骤（a）中提供的胰酶的病毒感染性相比，步骤（b）中获得的胰酶的病毒感染性已经降低了大于1log10的因子，以及根据该方法制备的胰酶 及其用于生产药物或营养补充剂的用途。
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2.发明授权Method for reducing the viral and microbial load of biological extracts containing solids 有权减少包含固体的生物提取物的病毒和微生物负荷的方法公开(公告)号：US09107966B2
公开(公告)日：2015-08-18
申请号：US13060712
申请日：2009-08-27
CPC分类号： A61L2/0011 , A61K38/00 , C12N9/94
摘要： The invention is a method for reducing the viral and microbial content of biological extracts which contain solids. The method comprises the steps of, (1), providing a biological extract which contains solids that comprise a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (2) subjecting the biological extract to a high-pressure treatment; wherein the biological activity of the biological extract after the high-pressure treatment is at least 50% of the biological activity of the biological extract before the high-pressure treatment.
摘要翻译： 本发明是减少含有固体的生物提取物的病毒和微生物含量的方法。 该方法包括以下步骤：（1）提供含有选自酶，蛋白质和肽或这些物质的混合物的生物活性物质的固体的生物提取物; 和（2）对生物提取物进行高压处理; 其中，高压处理后的生物提取物的生物活性为高压处理前生物提取物的生物活性的至少50％。
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3.发明申请METHOD FOR REDUCING THE VIRAL AND MICROBIAL LOAD OF BIOLOGICAL EXTRACTS CONTAINING SOLIDS 有权减少含有固体的生物提取物的病毒和微生物负荷的方法公开(公告)号：US20110268844A1
公开(公告)日：2011-11-03
申请号：US13060712
申请日：2009-08-27
CPC分类号： A61L2/0011 , A61K38/00 , C12N9/94
摘要： The invention relates to a method for reducing the viral and microbial content of biological extracts which contain solids. It is provided that the method comprises the steps (a) provision of the biological extract which contains solids, comprising a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (b) subjecting the biological extract provided in step (a) to a high-pressure treatment; wherein the biological activity of the biological extract which contains solids after the high-pressure treatment is at least 50% of the biological activity of the biological extract which contains solids before the high-pressure treatment.
摘要翻译： 本发明涉及一种减少含有固体的生物提取物的病毒和微生物含量的方法。 提供的方法包括步骤（a）提供含有选自酶，蛋白质和肽的生物活性物质或这些物质的混合物的固体的生物提取物; 和（b）对步骤（a）中提供的生物提取物进行高压处理; 其中在高压处理后含有固体的生物提取物的生物活性是在高压处理前含有固体的生物提取物的生物活性的至少50％。
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4.发明申请METHOD FOR REDUCING THE VIRUS AND MICRO-ORGANISM CONTENT OF BIOLOGICAL EXTRACTS WHICH CONTAIN SOLIDS AND EXTRACT PRODUCED ACCORDING TO THE METHOD 审中-公开减少包含固体和生物提取物的生物提取物的病毒和微生物含量的方法公开(公告)号：US20100119654A1
公开(公告)日：2010-05-13
申请号：US12311894
申请日：2008-08-07
IPC分类号： A23L1/28 , C07K14/435
CPC分类号： C07K14/435 , A61K41/0019 , A61L2/0011 , A61L2/0035
摘要： The invention relates to a method for reducing the virus and micro-organism content of biological extracts which contain solids. It is provided that the method comprises the steps (a) provision of a biological extract which contains solids in the form of a suspension, which consists of a liquid phase and solid particles dispersed therein, wherein the extract in step (a) comprises a mixture of enzymes, proteins and peptides, some of which is dissolved in the liquid phase and some of which can be bound to the solid particles or is present in pulverulent, solid form; and (b) irradiation of the biological extract provided in step (a); wherein the radiation used for the irradiation is selected from the group comprising ultra-violet radiation, x-ray radiation, β radiation and γ radiation; and the enzymic activity of the biological extract which contains solids after irradiation is at least 50% of the enzymic activity of the biological extract which contains solids before irradiation.
摘要翻译： 本发明涉及一种减少含有固体的生物提取物的病毒和微生物含量的方法。 条件是该方法包括步骤（a）提供含有悬浮液形式的固体的生物提取物，其由分散在其中的液相和固体颗粒组成，其中步骤（a）中的提取物包含混合物 的酶，蛋白质和肽，其中一些溶解在液相中，其中一些可以结合固体颗粒或以粉末状固体形式存在; 和（b）照射步骤（a）中提供的生物提取物; 其中用于照射的辐射选自紫外辐射，x射线辐射， 辐射和γ辐射; 并且在照射后含有固体的生物提取物的酶活性是在照射前含有固体的生物提取物的酶活性的至少50％。
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