公开(公告)号：US09107966B2

公开(公告)日：2015-08-18

申请号：US13060712

申请日：2009-08-27

申请人： Christian Rämsch ,  Thomas Schräder ,  Thomas Moest ,  Manfred Kurfürst

发明人： Christian Rämsch ,  Thomas Schräder ,  Thomas Moest ,  Manfred Kurfürst

IPC分类号： C12N9/00 ,  A23L1/305 ,  A23L1/28 ,  A61L2/00 ,  C12N9/94 ,  A61K38/00

CPC分类号： A61L2/0011 ,  A61K38/00 ,  C12N9/94

摘要： The invention is a method for reducing the viral and microbial content of biological extracts which contain solids. The method comprises the steps of, (1), providing a biological extract which contains solids that comprise a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (2) subjecting the biological extract to a high-pressure treatment; wherein the biological activity of the biological extract after the high-pressure treatment is at least 50% of the biological activity of the biological extract before the high-pressure treatment.

摘要翻译： 本发明是减少含有固体的生物提取物的病毒和微生物含量的方法。 该方法包括以下步骤：（1）提供含有选自酶，蛋白质和肽或这些物质的混合物的生物活性物质的固体的生物提取物; 和（2）对生物提取物进行高压处理; 其中，高压处理后的生物提取物的生物活性为高压处理前生物提取物的生物活性的至少50％。

公开(公告)号：US06811054B1

公开(公告)日：2004-11-02

申请号：US10009061

申请日：2002-04-11

申请人： Thomas Moest ,  Ludwig Matz

发明人： Thomas Moest ,  Ludwig Matz

IPC分类号： G07F1156

CPC分类号： A61J7/0023 ,  A61J7/0053 ,  A61J7/02

摘要： A dosing spoon for microtablets is described for which the lower part (1) of the spoon consists of an even polygone which possesses a border (2) on all sides with exception of one side and whereby the polygone has a number of individual recesses (3) which are formed in such a way that an individual microtablet fits in each individual recess.

摘要翻译： 描述了用于微片的计量匙，其中勺子的下部（1）由均匀的多边形组成，除了一侧之外，所有侧面都具有边界（2），并且由此多边形具有多个单独的凹部（3 ），其以这样的方式形成，使得各个微片安装在每个单独的凹部中。

公开(公告)号：US08283147B2

公开(公告)日：2012-10-09

申请号：US12403697

申请日：2009-03-13

申请人： Manfred Kurfürst ,  Christian Rämsch ,  Thomas Schräder ,  Thomas Moest

发明人： Manfred Kurfürst ,  Christian Rämsch ,  Thomas Schräder ,  Thomas Moest

IPC分类号： C12N9/94

CPC分类号： C12N9/94 ,  A61L2/0023

摘要： The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.

摘要翻译： 本发明涉及一种生产具有减少的病毒和微生物污染的胰酶的方法，其包括以下步骤：（a）基于所提供的胰酶，提供固体形式的胰酶，残留水分为0.5重量％或更少，至少几乎为零 ; （b）使步骤（a）中提供的胰酶在84℃，优选80℃及以下的温度下进行热处理; 其中，步骤（b）中获得的胰酶的生物活性对应于步骤（a）中提供的胰酶的生物活性的至少50％。 与步骤（a）中提供的胰酶的病毒感染性相比，步骤（b）中获得的胰酶的病毒感染性已经降低了大于1log10的因子，以及根据该方法制备的胰酶 及其用于生产药物或营养补充剂的用途。

公开(公告)号：US5453280A

公开(公告)日：1995-09-26

申请号：US117285

申请日：1993-09-07

申请人： Thomas Moest ,  Uwe Loeffler ,  Hans Waiblinger

发明人： Thomas Moest ,  Uwe Loeffler ,  Hans Waiblinger

IPC分类号： A61K9/16 ,  A61K31/135 ,  A61K31/137 ,  A61K9/54 ,  B29B9/08 ,  B29B9/16

CPC分类号： A61K31/135 ,  A61K9/1688

摘要： A process for producing pellets which are markedly spherical and have a particle size in the range from 0.1 to 4 mm and an apparent density above 0.5 g/cm.sup.3, and which are composed of 90-100% by weight of an ephedrine derivative and 0-10% by weight of a pharmaceutical aid, entails suspending ephedrine derivative powder with an average particle size of from 0.5 to 50 .mu.m at 0.degree.-90.degree. C. with stirring in a water-immiscible non solvent with a boiling point in the range from 60.degree. to 160.degree. C., adding 5-60% by weight, based on the ephedrine derivative, of an agglomerating liquid while continuing stirring, and, if there has been previous heating, cooling to from -5 to 25.degree. C. at 5-40K per hour, with the stirring speed being adjusted after the agglomeration of the powder particles to a value which is necessary for the required average particle size, and removing and drying the resulting pellets. A drug which contains the active ingredient in the form of such pellets, with or without slowing of release, is also described.

摘要翻译： 一种制备显影球形，粒径为0.1〜4mm，表观密度为0.5g / cm 3以上的颗粒的方法，由90-100重量％的麻黄碱衍生物和0〜 10重量％的药物助剂，需要在0〜90℃下搅拌平均粒度为0.5〜50μm的麻黄碱衍生物粉末，在沸点范围内的不溶于水的非溶剂中搅拌 从60℃升至160℃，在连续搅拌的同时加入约5-60重量％的基于麻黄碱衍生物的附聚液，如果先前加热，冷却至-5〜25℃ 以每小时5-40K的速度调整粉末颗粒附聚后的搅拌速度至所需的平均颗粒尺寸所需的值，并除去和干燥所得的颗粒。 还描述了含有这种丸剂形式的活性成分的药物，其具有或没有减缓释放。

公开(公告)号：US5160469A

公开(公告)日：1992-11-03

申请号：US578442

申请日：1990-09-07

申请人： Thomas Moest ,  Claus H. Pich

发明人： Thomas Moest ,  Claus H. Pich

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K9/32 ,  A61K9/52 ,  A61K31/52

CPC分类号： A61K9/1688 ,  A61K31/52

摘要： A process for the manufacture of pellets which are composed of xanthine derivatives and are predominantly spherical, have a particle size in the range of 0.3 to 4 mm and have a bulk density above 0.5 g/cm.sup.3 by reacting the appropriate xanthine derivative with water or a water/alcohol mixture, entails anhydrous powdered xanthine derivative with an average particle size of from 20 to 200 .mu.m being suspended by stirring at from 40.degree. to 70.degree. C. in a nonsolvent which is immiscible with water and has a boiling point in the range from 60.degree. to 160.degree. C., then adding from 10 to 40% by weight, based on the anhydrous xanthine derivative, of water or a water/alcohol mixture and subsequently allowing to cool to room temperature at from 5.degree. to 20.degree. C. per hour, it being possible to reduce the stirring speed after agglomeration to about 1/3 to 2/3 of the original, and the pellets being separated from the liquid and dried, the pellets being used, possibly with a delayed release coating, as active compound in a drug.

摘要翻译： 制造由黄嘌呤衍生物构成的并且主要为球形的颗粒的方法具有0.3-4mm的粒径，并且通过使适当的黄嘌呤衍生物与水或 水/醇混合物，使平均粒度为20〜200μm的无水粉末黄嘌呤衍生物在40℃至70℃下搅拌悬浮，在与水不混溶的非溶剂中，并且沸点在 范围为60〜160℃，然后以无水黄嘌呤衍生物为基础，以无水黄嘌呤衍生物为10〜40重量％的水或水/醇混合物，然后在5〜20℃下冷却至室温。 每小时可以将凝聚后的搅拌速度降低到原料的约1/3至2/3，并将颗粒与液体分离并干燥，使用颗粒，可能具有延迟释放涂层 ，as 药物中的活性化合物。

公开(公告)号：US4828843A

公开(公告)日：1989-05-09

申请号：US210852

申请日：1988-06-24

申请人： Claus H. Pich ,  Thomas Moest

发明人： Claus H. Pich ,  Thomas Moest

IPC分类号： A61J3/10 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  B30B11/00 ,  B30B11/08 ,  B30B15/00

CPC分类号： B30B15/0094 ,  A61J3/10 ,  A61K9/2072 ,  A61K9/2866 ,  B30B11/005 ,  B30B11/08

摘要： Cylindrical microtablets which have a convex upper face and a convex lower face and whose cylinder diameter and height independently of one another are each from 1.0 to 2.5 mm and the ratio of the said diameter to said height is from 1:0.5 to 1:1.5, an a process for their preparation.

摘要翻译： 具有凸上表面和凸下表面以及圆柱体直径和高度彼此独立的圆柱形微片分别为1.0至2.5mm，所述直径与所述高度之比为1:0.5至1:1.5， 一个他们准备的过程。

公开(公告)号：US20110052706A1

公开(公告)日：2011-03-03

申请号：US12806942

申请日：2010-08-24

申请人： Thomas Moest ,  Manfred Kurfürst ,  Walter Doleschal

发明人： Thomas Moest ,  Manfred Kurfürst ,  Walter Doleschal

IPC分类号： A61K9/14 ,  A61K38/54 ,  A61P1/00 ,  A61P5/48 ,  C12N9/94

CPC分类号： A61K9/14 ,  A61K9/5031 ,  A61K9/5047 ,  A61K9/5073 ,  A61K9/5089 ,  A61K38/465 ,  A61K38/47 ,  A61K38/48 ,  A61K2300/00

摘要： In order to prevent impairment of the pharmacological effect of pancreatine through added auxiliary substances or binding agents a pancreatine pellet consists exclusively of pancreatine.

摘要翻译： 为了防止胰腺通过添加的辅助物质或粘合剂的药理作用受损，胰腺丸粒仅由胰腺组成。

公开(公告)号：US20100119654A1

公开(公告)日：2010-05-13

申请号：US12311894

申请日：2008-08-07

申请人： Christian Rämsch ,  Thomas Schräder ,  Thomas Moest ,  Manfred Kurfürat

发明人： Christian Rämsch ,  Thomas Schräder ,  Thomas Moest ,  Manfred Kurfürat

IPC分类号： A23L1/28 ,  C07K14/435

CPC分类号： C07K14/435 ,  A61K41/0019 ,  A61L2/0011 ,  A61L2/0035

摘要： The invention relates to a method for reducing the virus and micro-organism content of biological extracts which contain solids. It is provided that the method comprises the steps (a) provision of a biological extract which contains solids in the form of a suspension, which consists of a liquid phase and solid particles dispersed therein, wherein the extract in step (a) comprises a mixture of enzymes, proteins and peptides, some of which is dissolved in the liquid phase and some of which can be bound to the solid particles or is present in pulverulent, solid form; and (b) irradiation of the biological extract provided in step (a); wherein the radiation used for the irradiation is selected from the group comprising ultra-violet radiation, x-ray radiation, β radiation and γ radiation; and the enzymic activity of the biological extract which contains solids after irradiation is at least 50% of the enzymic activity of the biological extract which contains solids before irradiation.

摘要翻译： 本发明涉及一种减少含有固体的生物提取物的病毒和微生物含量的方法。 条件是该方法包括步骤（a）提供含有悬浮液形式的固体的生物提取物，其由分散在其中的液相和固体颗粒组成，其中步骤（a）中的提取物包含混合物 的酶，蛋白质和肽，其中一些溶解在液相中，其中一些可以结合固体颗粒或以粉末状固体形式存在; 和（b）照射步骤（a）中提供的生物提取物; 其中用于照射的辐射选自紫外辐射，x射线辐射， 辐射和γ辐射; 并且在照射后含有固体的生物提取物的酶活性是在照射前含有固体的生物提取物的酶活性的至少50％。

公开(公告)号：US5364635A

公开(公告)日：1994-11-15

申请号：US97057

申请日：1993-07-27

申请人： Helmut Fricke ,  Thomas Moest ,  Ernst Flaig

发明人： Helmut Fricke ,  Thomas Moest ,  Ernst Flaig

IPC分类号： A61K9/16 ,  A61K31/275

CPC分类号： A61K9/1688 ,  A61K31/275

摘要： A solid drug form containing not less than 90% by weight verapamil is produced by granulating at from 30.degree. to 55.degree. C. with a little water, drying and, where appropriate, conventional tableting or by pelleting, in which case the granules obtained as described are, after cooling, moistened once again and compacted in a granulating mixer at from 30.degree. to 55.degree. C. and are dried.

摘要翻译： 含有不少于90％（重量）维拉帕米的固体药物通过用少量水在30-55℃进行造粒，干燥和适当时通过造粒或通过造粒将其制成为 冷却后再次润湿，在30〜55℃的造粒混合机中压实，并干燥。

公开(公告)号：US4826043A

公开(公告)日：1989-05-02

申请号：US66996

申请日：1987-06-29

申请人： Ludwig Matz ,  Thomas Moest

发明人： Ludwig Matz ,  Thomas Moest

IPC分类号： G01F11/24 ,  B65D83/04 ,  G01F11/26

CPC分类号： B65D83/0409 ,  B65D83/04 ,  B65D2583/0495

摘要： In an apparatus for removing portions of identical materials (4) in the form of pieces by means of a sliding part which is encased in a dispensing container and operated from the outside and whose dispensing sector (5) is filled from inside the container and can be emptied outward, the sliding part is in the form of a tube section (1) which has one or more dispensing sectors (5) and is fed through an outer shell (3) and a stripper (2) located adjacent to the ejection orifice (9) and assigned to the dispensing sectors (5).

摘要翻译： 在用于通过滑动部分去除部分相同材料（4）的装置中，所述滑动部分被包装在分配容器中并从外部操作，并且其分配部分（5）从容器内部填充并且可以 被向外排空，滑动部分是具有一个或多个分配扇区（5）的管段（1）的形式，并且通过外部壳体（3）和位于喷射口附近的剥离器（2） （9）并分配给分配扇区（5）。