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公开(公告)号：US20110049751A1
公开(公告)日：2011-03-03
申请号：US12550153
申请日：2009-08-28
IPC分类号： B29C47/10
CPC分类号： A61L31/06 , A61F2/82 , A61F2210/0004 , A61L31/14 , B29C47/0023 , B29C47/0026 , B29C47/0035 , B29C47/28 , B29C47/38 , B29C47/702 , B29L2031/7542 , C08L67/04
摘要： Methods of fabricating a low crystallinity polymer tube for polymers subject to strain-induced crystallization. The low crystallinity tube may be further processed to make an implantable medical device.
摘要翻译： 制造用于应变诱导结晶的聚合物的低结晶度聚合物管的方法。 可以进一步处理低结晶度管以制造可植入的医疗装置。
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公开(公告)号：US08545742B2
公开(公告)日：2013-10-01
申请号：US12550153
申请日：2009-08-28
IPC分类号： B29C47/10
CPC分类号： A61L31/06 , A61F2/82 , A61F2210/0004 , A61L31/14 , B29C47/0023 , B29C47/0026 , B29C47/0035 , B29C47/28 , B29C47/38 , B29C47/702 , B29L2031/7542 , C08L67/04
摘要： Methods of fabricating a low crystallinity polymer tube for polymers subject to strain-induced crystallization. The low crystallinity tube may be further processed to make an implantable medical device.
摘要翻译： 制造用于应变诱导结晶的聚合物的低结晶度聚合物管的方法。 可以进一步处理低结晶度管以制造可植入的医疗装置。
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公开(公告)号：US08586125B2
公开(公告)日：2013-11-19
申请号：US12884106
申请日：2010-09-16
申请人： Syed F. A. Hossainy , Yiwen Tang , Manish B. Gada
发明人： Syed F. A. Hossainy , Yiwen Tang , Manish B. Gada
IPC分类号： A61L33/00
CPC分类号： A61F2/82 , A61F2/91 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/602 , A61L2420/02 , B29C71/02 , C08L67/04
摘要： A method of manufacturing an implantable medical device, such as a drug eluting stent, is disclosed. The method includes subjecting an implantable medical device that includes a polymer to a thermal condition. The thermal condition can result in reduction of the rate of release of an active agent from the device subsequent to the implantation of the device and/or improve the mechanical properties of a polymeric coating on the device.
摘要翻译： 公开了一种制造可植入医疗装置的方法，例如药物洗脱支架。 该方法包括使包含聚合物的可植入医疗装置经受热条件。 加热条件可导致活性剂从植入装置之后的装置释放速率降低，和/或改善装置上的聚合物涂层的机械性能。
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公开(公告)号：US20110066222A1
公开(公告)日：2011-03-17
申请号：US12558105
申请日：2009-09-11
申请人： Yunbing Wang , Manish B. Gada
发明人： Yunbing Wang , Manish B. Gada
CPC分类号： A61F2/91 , A61F2240/001 , B29C49/00 , B29C2049/0089 , B29L2031/7542
摘要： A stent may be formed from a PLLA tubular polymer construct that is deformed in a blow mold. A desirable polymer morphology resulting in improved stent performance is obtained with a selected radial axial expansion ratio from about 20% to about 70%, a selected radial expansion ratio from about 400% to about 500%, a selected axial rate of deformation propagation at or about 0.3 mm/minute, a selected expansion pressure at or about 130 psi, and a selected expansion temperature that does not exceed 200 deg F. The tubular polymer construct may also be made of PLGA, PLLA-co-PDLA, PLLD/PDLA stereocomplex, and PLLA-based polyester block copolymer containing a rigid segment of PLLA or PLGA and a soft segment of PCL or PTMC.
摘要翻译： 支架可以由在吹塑模具中变形的PLLA管状聚合物构件形成。 通过选择的径向轴向膨胀比为约20％至约70％，选定的径向膨胀比为约400％至约500％，选定的轴向变形扩展速率在或 约0.3mm /分钟，选定的膨胀压力为或约130psi，选择的膨胀温度不超过200华氏度。管状聚合物构造体还可以由PLGA，PLLA-co-PDLA，PLLD / PDLA立体络合物 ，以及含有PLLA或PLGA的刚性片段和PCL或PTMC的软片段的基于PLLA的聚酯嵌段共聚物。
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