公开(公告)号：US20100144642A1

公开(公告)日：2010-06-10

申请号：US12649687

申请日：2009-12-30

申请人： María del Carmen Domínguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marín ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Díaz ,  Nelson J. Merino García ,  Ariel Vázquez Bonachea ,  José Suárez Alba

发明人： María del Carmen Domínguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marín ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Díaz ,  Nelson J. Merino García ,  Ariel Vázquez Bonachea ,  José Suárez Alba

IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P29/00 ,  A61P19/02

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。