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1.发明授权Method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixtures 失效选择性肽分离方法用于鉴定和定量分析复杂混合物中的蛋白质公开(公告)号：US07244411B2
公开(公告)日：2007-07-17
申请号：US10988943
申请日：2004-11-15
申请人： Lázaro Hiram Betancourt Núñez , Jorge Fernández de Cossio Dorta-Duque , Vladimir Armando Besada Pérez , Jeovanis Gil Valdés , Luis Javier González López , Gabriel Ramón Padrón Palomares , Rolando Pajón Feyt , Félix Modesto Álvarez Gil
发明人： Lázaro Hiram Betancourt Núñez , Jorge Fernández de Cossio Dorta-Duque , Vladimir Armando Besada Pérez , Jeovanis Gil Valdés , Luis Javier González López , Gabriel Ramón Padrón Palomares , Rolando Pajón Feyt , Félix Modesto Álvarez Gil
CPC分类号： G01N33/6848 , C12Q1/37
摘要： The present invention describes a method of selective peptide isolation for the identification and quantitative analysis of proteins in complex mixture. The method comprises the selective isolation from every protein of those peptides that neither contain arginine nor histidine (NHNR peptides), and the determination of the relative concentrations of one or several proteins in different samples from the ratio between the areas of the estimated theoretical spectra for the NHNR peptides labeled with different isotopes in each sample. The determination of the relative concentration of proteins is valid for any type of isotopic label of the NHNR peptides. The method avoids the separation and purification of the proteins present in a complex mixture, and the analysis of all peptides generated from the enzymatic digest of the samples. The method is applicable to the identification of proteins with vacunal, therapeutic and diagnostic aims.
摘要翻译： 本发明描述了用于鉴定和定量分析复合物中蛋白质的选择性肽分离方法。 该方法包括从不含精氨酸和组氨酸（NHNR肽）的那些肽的每种蛋白质的选择性分离，以及将不同样品中一种或几种蛋白质的相对浓度与估计的理论光谱面积之比 在每个样品中用不同同位素标记的NHNR肽。 蛋白质的相对浓度的测定对于NHNR肽的任何类型的同位素标记是有效的。 该方法避免了复杂混合物中存在的蛋白质的分离和纯化，以及从样品的酶促消化产生的所有肽的分析。 该方法适用于鉴定具有病毒，治疗和诊断目的的蛋白质。
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2.发明授权Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions 有权衍生自HSP60的肽和改变的肽配体和药物组合物公开(公告)号：US08324164B2
公开(公告)日：2012-12-04
申请号：US12649687
申请日：2009-12-30
申请人： Maria del Carmen Domínguez Horta , Gabriel Ramón Padrón Palomares , Nelia López Marin , Norailys Lorenzo Perez , Ariana Barberá Betancourt , Ariadna Hernández Garcia , Vivian Morera Cordova , Carelia Cosme Diaz , Nelson J. Merino Garcia , Ariel Vázquez Bonachea , José Suárez Alba
发明人： Maria del Carmen Domínguez Horta , Gabriel Ramón Padrón Palomares , Nelia López Marin , Norailys Lorenzo Perez , Ariana Barberá Betancourt , Ariadna Hernández Garcia , Vivian Morera Cordova , Carelia Cosme Diaz , Nelson J. Merino Garcia , Ariel Vázquez Bonachea , José Suárez Alba
摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。
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3.发明申请公开(公告)号：US20100144642A1
公开(公告)日：2010-06-10
申请号：US12649687
申请日：2009-12-30
申请人： María del Carmen Domínguez Horta , Gabriel Ramón Padrón Palomares , Nelia López Marín , Norailys Lorenzo Perez , Ariana Barberá Betancourt , Ariadna Hernández Garcia , Vivian Morera Cordova , Carelia Cosme Díaz , Nelson J. Merino García , Ariel Vázquez Bonachea , José Suárez Alba
发明人： María del Carmen Domínguez Horta , Gabriel Ramón Padrón Palomares , Nelia López Marín , Norailys Lorenzo Perez , Ariana Barberá Betancourt , Ariadna Hernández Garcia , Vivian Morera Cordova , Carelia Cosme Díaz , Nelson J. Merino García , Ariel Vázquez Bonachea , José Suárez Alba
摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。
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4.发明授权公开(公告)号：US08383771B2
公开(公告)日：2013-02-26
申请号：US11663603
申请日：2005-09-22
申请人： Maria del Carmen Dominguez Horta , Gabriel Ramón Padrón Palomares , Nelia López Marin , Norailys Lorenzo Perez , Ariana Barberá Betancourt , Ariadna Hernández Garcia , Vivian Morera Cordova , Carelia Cosme Diaz , Nelson J. Merino Garcia , Ariel Vázquez Bonachea , José Suárez Alba
发明人： Maria del Carmen Dominguez Horta , Gabriel Ramón Padrón Palomares , Nelia López Marin , Norailys Lorenzo Perez , Ariana Barberá Betancourt , Ariadna Hernández Garcia , Vivian Morera Cordova , Carelia Cosme Diaz , Nelson J. Merino Garcia , Ariel Vázquez Bonachea , José Suárez Alba
摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。
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5.发明申请公开(公告)号：US20110212105A1
公开(公告)日：2011-09-01
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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