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    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
    1.
    发明申请
    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权
    用于产生脂质含量降低的HDL颗粒衍生物的方法和装置

    公开(公告)号：US20050004004A1

    公开(公告)日：2005-01-06

    申请号：US10796691

    申请日：2004-03-08

    申请人： Marc Bellotti ,  H. Brewer ,  Hassibullah Akeefe ,  Adam Conner ,  Timothy Perlman

    发明人： Marc Bellotti ,  H. Brewer ,  Hassibullah Akeefe ,  Adam Conner ,  Timothy Perlman

    IPC分类号： A61K9/127 ,  A61K38/17

    CPC分类号： G01N33/92 ,  A61K9/1275 ,  A61K38/1709 ,  C07K14/775 ,  A61K2300/00

    摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

    摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本方法可用于治疗动脉粥样硬化性血管疾病，并可与其他疗法（如他汀类药物，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制）结合使用。

    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
    3.
    发明申请
    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权
    用于产生脂质含量降低的HDL颗粒衍生物的方法和装置

    公开(公告)号：US20060172939A1

    公开(公告)日：2006-08-03

    申请号：US11260861

    申请日：2005-10-26

    申请人： Marc Bellotti ,  H. Brewer ,  Hassibullah Akeefe ,  Adam Conner ,  Timothy Perlman

    发明人： Marc Bellotti ,  H. Brewer ,  Hassibullah Akeefe ,  Adam Conner ,  Timothy Perlman

    IPC分类号： A61K38/17 ,  A61K31/685

    CPC分类号： C07K14/775 ,  A61K9/1275 ,  A61K31/685 ,  A61K38/1709 ,  B01D11/0492 ,  B01D15/00 ,  B01D15/426 ,  G01N33/92 ,  A61K2300/00

    摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

    摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。

    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
    6.
    发明授权
    Methods and apparatus for creating particle derivatives of HDL with reduced lipid content 有权
    用于产生脂质含量降低的HDL颗粒衍生物的方法和装置

    公开(公告)号：US07361739B2

    公开(公告)日：2008-04-22

    申请号：US10996570

    申请日：2004-11-23

    申请人： Marc Bellotti ,  H. Bryan Brewer, Jr. ,  Hassibullah Akeefe ,  Adam Paul Conner ,  Timothy Jon Perlman

    发明人： Marc Bellotti ,  H. Bryan Brewer, Jr. ,  Hassibullah Akeefe ,  Adam Paul Conner ,  Timothy Jon Perlman

    IPC分类号： C07K1/00

    CPC分类号： G01N33/92 ,  A61K9/1275 ,  A61K38/1709 ,  C07K14/775 ,  A61K2300/00

    摘要： The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of HDL without substantially affecting LDL. These derivatives of HDL are particles with reduced lipid content, particularly reduced cholesterol content. These particles have the capacity to bind cholesterol and are administered to a patient to enhance cellular cholesterol efflux and reduce cholesterol levels in cells, tissues, organs, and blood vessels. The present method is useful for treating atherogenic vascular disease and may be combined with other therapies such as statins, inhibitors of cholesterol absorption, niacin, anti-inflammatories, exercise and dietary restriction.

    摘要翻译： 本发明涉及用于产生HDL的至少一种形式的衍生物而不显着影响LDL的系统，装置和方法。 HDL的这些衍生物是具有降低的脂质含量的颗粒，特别是降低的胆固醇含量。 这些颗粒具有结合胆固醇的能力，并且给予患者以增强细胞，胆固醇的流出并降低细胞，组织，器官和血管中的胆固醇水平。 本发明方法可用于治疗动脉粥样化性血管疾病，并且可与其他治疗如他汀类，胆固醇吸收抑制剂，烟酸，抗炎药，运动和饮食限制组合。