公开(公告)号：US08517972B2

公开(公告)日：2013-08-27

申请号：US13530253

申请日：2012-06-22

Applicant: Marc Graham ,  Buket Grau

Inventor： Marc Graham ,  Buket Grau

IPC: A61F2/04

CPC classification number: A61F5/0079

Abstract: A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.

Abstract translation: 本文公开了一种用于调节患者胃肠道幽门区域中流体流动的幽门阀。 在一个实施例中，幽门阀包括沿着阀的纵向轴线沿近端到远端方向定位的多个轴向连接的阻挡构件。 阀的每个阻塞构件优选地包括限定至少一个入口通道的至少一个阻挡部分，该至少一个入口适于接收通过其中的诸如手杖之类的流体。 每个阻挡构件的至少一个入口通道优选地不沿着纵向轴线对准与其相邻的每个阻挡构件的至少一个入口。 阻挡构件的至少一个入口通道的不对准优选地产生用于流体（例如食糜）流过患者幽门区域的非线性路径。

公开(公告)号：US20110004228A1

公开(公告)日：2011-01-06

申请号：US12702411

申请日：2010-02-09

Applicant: Attila A. Priplata ,  Marc Graham ,  Joseph P. Errico ,  John T. Raffle ,  Jonathan David Gardiner

Inventor： Attila A. Priplata ,  Marc Graham ,  Joseph P. Errico ,  John T. Raffle ,  Jonathan David Gardiner

IPC: A61B17/11

CPC classification number: A61F5/0076 ,  A61B17/3468 ,  A61B2017/00557 ,  A61B2017/00818 ,  A61F5/004 ,  A61F5/0079 ,  A61F2002/045 ,  A61M25/04 ,  A61M27/002 ,  A61M39/00 ,  A61M39/10

Abstract: The present invention provides systems and methods for treating and/or controlling obesity and type II diabetes. In one aspect of the invention, a device for treating obesity includes a flow restrictor and an anchor coupled to the flow restrictor. The flow restrictor is movable between a first or collapsed configuration sized and shaped for endoscopic advancement through the patient's esophagus and into a distal region of the stomach and a second or operative configuration sized and shaped for inhibiting a flow of chyme from the stomach to the pyloric sphincter. It is believed that this will cause the prolongation of satiety, and result in fewer meals being eaten and/or smaller meals being ingested. The anchor is movable between a first or collapsed configuration sized and shaped for advancement through the esophagus, stomach and pyloric sphincter and into the proximal region of the duodenum and a second or operative configuration sized and shaped to inhibit proximal movement of the anchor through the pyloric sphincter.

Abstract translation: 本发明提供用于治疗和/或控制肥胖症和II型糖尿病的系统和方法。 在本发明的一个方面，一种用于治疗肥胖症的装置包括流量限制器和连接到限流器的锚固器。 限流器可在第一或塌陷构造之间移动，其尺寸和形状用于通过患者食道进入内窥镜前进并进入胃的远端区域，以及第二或可操作构造，其尺寸和形状用于抑制食糜从胃向幽门的流动 括约肌 相信这将导致饱腹感的延长，并且导致被摄入的食物减少和/或被摄入的较小的食物。 锚固件可以在尺寸和形状适于通过食道，胃和幽门括约肌进入并进入十二指肠的近端区域的第一或塌陷构造之间移动，以及尺寸和形状的第二或可操作构造，以阻止锚通过幽门的近端运动 括约肌

公开(公告)号：US20090259240A1

公开(公告)日：2009-10-15

申请号：US12420219

申请日：2009-04-08

Applicant: Marc Graham ,  Buket Grau

Inventor： Marc Graham ,  Buket Grau

IPC: A61B17/08

CPC classification number: A61F5/0079

Abstract: A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.

Abstract translation: 本文公开了一种用于调节患者胃肠道幽门区域中流体流动的幽门阀。 在一个实施例中，幽门阀包括沿着阀的纵向轴线沿近端到远端方向定位的多个轴向连接的阻挡构件。 阀的每个阻塞构件优选地包括限定至少一个入口通道的至少一个阻挡部分，该至少一个入口适于接收通过其中的诸如手杖之类的流体。 每个阻挡构件的至少一个入口通道优选地不沿着纵向轴线对准与其相邻的每个阻挡构件的至少一个入口。 阻挡构件的至少一个入口通道的不对准优选地产生用于流体（例如食糜）流过患者幽门区域的非线性路径。

公开(公告)号：US20080125796A1

公开(公告)日：2008-05-29

申请号：US11998345

申请日：2007-11-28

Applicant: Marc Graham

Inventor： Marc Graham

IPC: A61B17/10 ,  A61B1/018 ,  A61M29/02

CPC classification number: A61B17/0057 ,  A61B17/00491 ,  A61B17/0218 ,  A61B17/083 ,  A61B17/1227 ,  A61B2017/00557 ,  A61B2017/00575 ,  A61B2017/00592 ,  A61B2017/00615

Abstract: Apparatus and methods for sealing an aperture in body tissue that extends from an outside surface to an inside surface of the body tissue is described. One embodiment of the apparatus includes an expandable material positioned against at least a portion of an expandable member, the expandable material having a sealing surface adapted to expand against the inside surface of the body tissue surrounding the aperture as the expandable member expands. In an alternative embodiment, tissue is pulled by a retractor mechanism between two biased legs of a deformable clip that is loaded on a trigger. As a base of the trigger is moved away from a base of a housing, the clip is released from the trigger causing the two biased legs of the clip to come together and seal tissue therebetween. Generally, the apparatus of each embodiment is delivered to an aperture site through an endoscope.

Abstract translation: 描述了用于密封从身体组织的外表面延伸到内表面的身体组织中的孔的装置和方法。 该装置的一个实施例包括抵靠可扩张构件的至少一部分定位的可膨胀材料，所述可膨胀材料具有密封表面，所述密封表面适于当可膨胀构件膨胀时抵靠围绕孔的身体组织的内表面膨胀。 在替代实施例中，组织被牵引器机构牵引在可加载在触发器上的可变形夹子的两个偏压腿之间。 当触发器的基座远离壳体的基部移动时，夹子从触发器释放，导致夹子的两个偏置腿部彼此聚集并密封组织。 通常，每个实施例的装置通过内窥镜传送到孔径部位。

公开(公告)号：US20160135799A1

公开(公告)日：2016-05-19

申请号：US14937554

申请日：2015-11-10

Applicant: Joshua Aaron Lessing ,  Ryan Richard Knopf ,  Marc Graham ,  Carl Vause

Inventor： Joshua Aaron Lessing ,  Ryan Richard Knopf ,  Marc Graham ,  Carl Vause

IPC: A61B17/02

CPC classification number: A61B17/02 ,  A61B17/0218 ,  A61B34/70 ,  A61B2017/00017 ,  A61B2017/00557

Abstract: Exemplary embodiments describe soft robotic actuators for medical use, such as during surgeries and other medical procedures. According to one embodiment, a soft robotic incision retractor is provided. According to another embodiment, a soft robotic body tissue retractor is provided. The incision retractor and body tissue refractor may be used together, for example by using the incision retractor to hold open an incision while the body tissue retractor manipulates biological matter or an object accessible through the incision. Described embodiments offer the ability to conform to a given space, reduced risk of damage to surrounding structures as compared to traditional retractors, the ability to deliver varying amounts of force, the ability to be made from medically safe materials, and the potential for re-use or disposability.

Abstract translation: 示例性实施例描述用于医疗用途的软式机器人致动器，例如在手术和其他医疗过程期间。 根据一个实施例，提供了一种软式自动切口牵开器。 根据另一个实施例，提供了一种软的机器人身体组织牵缩器。 切口牵开器和身体组织折射器可以一起使用，例如通过使用切口牵开器在身体组织牵开器操纵生物物质或通过切口可接近的物体时保持开口切口。 描述的实施例提供了符合给定空间的能力，与传统牵缩器相比降低了对周围结构的损害风险，提供不同程度的力的能力，由医疗安全的材料制成的能力以及重新形成的潜力， 使用或一次性。

公开(公告)号：US08182442B2

公开(公告)日：2012-05-22

申请号：US12384889

申请日：2009-04-09

Applicant: Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

Inventor： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

IPC: A61M5/00 ,  A61B17/08 ,  A61F2/04

CPC classification number: A61F5/0079 ,  A61F5/0089

Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a plurality of disc-shaped flanges connected in series. The blocking portion may be disposed in a contracted position wherein the plurality of disc-shaped flanges is disposed in a stacked configuration and a resting position wherein the plurality of disc-shaped flanges is disposed in a linear configuration. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its resting and contracted positions. Insertion and removal systems are also provided for use with the pyloric valve.

Abstract translation: 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括具有串联连接的多个圆盘形凸缘的阻挡部分。 阻挡部分可以设置在收缩位置，其中多个盘形凸缘以堆叠构造设置，并且静止位置，其中多个盘形凸缘以线性构造布置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其休息位置和收缩位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。

公开(公告)号：US08100850B2

公开(公告)日：2012-01-24

申请号：US12384898

申请日：2009-04-09

Applicant: Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

Inventor： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

IPC: A61M5/00 ,  A61B17/08

CPC classification number: A61F5/0079 ,  A61F5/0089

Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.

Abstract translation: 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括阻挡部分，其具有限定中心开口的至少一个轴向对准的环形凸缘和具有边缘和支撑表面的支撑件。 支撑件可以设置在嵌套位置，其中支撑表面设置在中心开口内，并且倒置位置，其中支撑表面远离中心开口设置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其倒置位置和嵌套位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。

公开(公告)号：US08579849B2

公开(公告)日：2013-11-12

申请号：US13363509

申请日：2012-02-01

Applicant: Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

Inventor： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

IPC: A61M5/00 ,  A61F2/04

CPC classification number: A61F5/0079 ,  A61F5/0089

Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having a disc-shaped inlet and a helical flange. The helical flange may be disposed in a contracted position defining a contracted length and a contracted diameter and an extended position defining an extended length and an extended diameter, wherein the extended length is longer than the contracted length and the extended diameter is smaller than the contracted diameter. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its contracted and extended positions. Insertion and removal systems are also provided for use with the pyloric valve.

公开(公告)号：US20130006381A1

公开(公告)日：2013-01-03

申请号：US13336196

申请日：2011-12-23

Applicant: Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

Inventor： Buket Grau ,  David Robert Gale ,  Sam Anne Musgrave ,  George McGee Perkins ,  Mark Jeffrey Edhouse ,  Marc Graham ,  Christopher Kadamus

IPC: A61F2/04

CPC classification number: A61F5/0079 ,  A61F5/0089

Abstract: A pyloric valve is provided for inhibiting the flow of chyme through the pyloric region of the gastrointestinal tract. The pyloric valve includes a blocking portion having at least one axially-aligned annular flange defining a central opening and a support having a rim and a support surface. The support may be disposed in a nested position wherein the support surface is disposed within the central opening and an inverted position wherein the support surface is disposed away from the central opening. The pyloric valve may further include a sleeve that may have a beveled distal end. The pyloric valve may be constructed of silicon. Also provided are methods of inserting and removing the pyloric valve, which each include a step of manipulating the support between its inverted and nested positions. Insertion and removal systems are also provided for use with the pyloric valve.

Abstract translation: 提供幽门阀用于抑制食道通过胃肠道幽门区域的流动。 幽门阀包括阻挡部分，其具有限定中心开口的至少一个轴向对准的环形凸缘和具有边缘和支撑表面的支撑件。 支撑件可以设置在嵌套位置，其中支撑表面设置在中心开口内，并且倒置位置，其中支撑表面远离中心开口设置。 幽门阀还可以包括可具有斜切远端的套筒。 幽门阀可以由硅构成。 还提供了插入和移除幽门阀的方法，每个都包括在其倒置位置和嵌套位置之间操纵支撑件的步骤。 还提供插入和移除系统以用于幽门阀。

公开(公告)号：US20120259427A1

公开(公告)日：2012-10-11

申请号：US13530253

申请日：2012-06-22

Applicant: Marc Graham ,  Buket Grau

Inventor： Marc Graham ,  Buket Grau

IPC: A61F2/04

CPC classification number: A61F5/0079

Abstract: A pyloric valve for regulating the flow of fluids in the pyloric region a patient's gastrointestinal tract is disclosed herein. In one embodiment, a pyloric valve includes a plurality of axially connected blocking members located along a longitudinal axis of the valve in a proximal to distal direction. Each blocking member of the valve preferably includes at least one blocking portion defining at least one entryway adapted to receive fluids such as chyme therethrough. The at least one entryway of each blocking member is preferably not aligned with the at least one entryway of each blocking member adjacent thereto along the longitudinal axis. The non-alignment of the at least one entryways of the blocking members preferably creates a non-linear path for fluids such as chyme to travel through the pyloric region of the patient.

Abstract translation: 本文公开了一种用于调节患者胃肠道幽门区域中流体流动的幽门阀。 在一个实施例中，幽门阀包括沿着阀的纵向轴线沿近端到远端方向定位的多个轴向连接的阻挡构件。 阀的每个阻塞构件优选地包括限定至少一个入口通道的至少一个阻挡部分，该至少一个入口适于接收通过其中的诸如手杖之类的流体。 每个阻挡构件的至少一个入口通道优选地不沿着纵向轴线对准与其相邻的每个阻挡构件的至少一个入口。 阻挡构件的至少一个入口通道的不对准优选地产生用于流体（例如食糜）流过患者幽门区域的非线性路径。