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公开(公告)号：US07700118B2
公开(公告)日：2010-04-20
申请号：US12049063
申请日：2008-03-14
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
IPC分类号： A61K39/04 , A61K39/205 , A61K39/00
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tubercuosis to attenuate the pathogenic bacteria.
摘要翻译： 在分枝杆菌分离株中鉴定了特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.tb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。
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公开(公告)号：US06291190B1
公开(公告)日：2001-09-18
申请号：US09318191
申请日：1999-05-25
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
IPC分类号： G01N3353
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletions are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tuberculosis to attenuate the pathogenic bacteria.
摘要翻译： 在分枝杆菌分离物中鉴定特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.bb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。
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3.发明申请公开(公告)号：US20080254052A1
公开(公告)日：2008-10-16
申请号：US12049063
申请日：2008-03-14
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tubercuosis to attenuate the pathogenic bacteria.
摘要翻译： 在分枝杆菌分离株中鉴定了特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.bb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。
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公开(公告)号：US07364740B2
公开(公告)日：2008-04-29
申请号：US11143401
申请日：2005-06-01
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tuberculosis to attenuate the pathogenic bacteria.
摘要翻译： 在分枝杆菌分离株中鉴定了特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.tb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。
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公开(公告)号：US06686166B2
公开(公告)日：2004-02-03
申请号：US09894844
申请日：2001-06-27
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael A. Wilson
IPC分类号： G01N3353
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletions are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tuberculosis to attenuate the pathogenic bacteria.
摘要翻译： 在分枝杆菌分离物中鉴定特异性遗传缺失，包括分离株之间的结核分枝杆菌基因组序列的变异，以及与M.bb相比在BCG中存在的许多缺失。 这些缺失被用作区分病原菌和无毒菌株的标记物，并且作为特异性M.tb菌株的标记物。 对BCG疫苗株特异性的缺失可用于确定阳性结核菌素皮肤试验是否表明实际的结核病感染。 可将经删除的序列重新引入BCG以提高疫苗接种的效力。 或者，对应于缺失的遗传序列从牛分枝杆菌或结核分枝杆菌中缺失，以减毒病原菌。
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公开(公告)号：US20060002953A1
公开(公告)日：2006-01-05
申请号：US11143401
申请日：2005-06-01
申请人： Marcel Behr , Peter Small , Gary Schoolnik , Michael Wilson
发明人： Marcel Behr , Peter Small , Gary Schoolnik , Michael Wilson
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Specific genetic deletion are identified in mycobacteria isolates, including variations in the M. tuberculosis genome sequence between isolates, and numerous deletion present in BCG as compared to M. tb. These deletions are used as markers to distinguish between pathogenic and avirulent strains, and as a marker for particular M. tb isolates. Deletions specific to vaccine strains of BCG are useful in determining whether a positive tuberculin skin test is indicative of actual tuberculosis infection. The deleted sequences may be re-introduced into BCG to improve the efficacy of vaccination. Alternatively, the genetic sequence that corresponds to the deletion(s) are deleted from M. bovis or M. tuberculosis to attenuate the pathogenic bacteria.
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公开(公告)号：US4729883A
公开(公告)日：1988-03-08
申请号：US903963
申请日：1986-09-05
申请人： Chi W. Lam , Terence J. Ritter , Peter Small
发明人： Chi W. Lam , Terence J. Ritter , Peter Small
CPC分类号： B01D53/1493 , C10K1/122 , Y02C10/06 , Y02P20/152
摘要： The invention relates to a process for the removal of acid gases from gaseous mixtures wherein said mixture is contacted with an aqueous alkaline solution comprising a compound of an alkali metal or ammonia and an alkanolamine-based promoter characterized in that the promoter is a mixture of at least one secondary alkanolamine and at least one N-alkyl-2-aminoethanol, said alkyl radical containing up to 3 carbon atoms.
摘要翻译： 本发明涉及从气态混合物中除去酸性气体的方法，其中所述混合物与包含碱金属或氨的化合物和基于链烷醇胺的助催化剂的碱性水溶液接触，其特征在于助催化剂是 至少一个仲烷醇胺和至少一个N-烷基-2-氨基乙醇，所述烷基含有至多3个碳原子。
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