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1.发明授权公开(公告)号：US06900175B2
公开(公告)日：2005-05-31
申请号：US10714261
申请日：2003-11-14
申请人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard J. White
发明人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard J. White
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection.
摘要翻译： 本发明提供了用于治疗细菌感染的方法和组合物。 本发明的方法包括给予达巴万星治疗细菌感染，特别是皮肤和软组织的革兰氏阳性细菌感染。 给药方案包括每周一次给予达巴万星，达巴万星通常在血液中保持治疗水平至少一周，为细菌感染提供长时间的治疗作用。
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2.发明授权Stable pharmaceutical compositions of dalbavancin and methods of administration 有权稳定的达巴万星的药物组合物及给药方法公开(公告)号：US07115564B2
公开(公告)日：2006-10-03
申请号：US10828439
申请日：2004-04-16
申请人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard J. White
发明人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard J. White
IPC分类号： A61K38/16
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection.
摘要翻译： 本发明提供了用于治疗细菌感染的方法和组合物。 本发明的方法包括给予达巴万星治疗细菌感染，特别是皮肤和软组织的革兰氏阳性细菌感染。 给药方案包括每周一次给予达巴万星，达巴万星通常在血液中保持治疗水平至少一周，为细菌感染提供长时间的治疗作用。
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3.发明申请Methods of administering dalbavancin for treatment of skin and soft tissue infections 审中-公开给予达巴万星治疗皮肤和软组织感染的方法公开(公告)号：US20050130914A1
公开(公告)日：2005-06-16
申请号：US10942604
申请日：2004-09-15
申请人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard White
发明人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard White
IPC分类号： A61K31/70 , A61K31/704 , A61K38/12 , A61K38/14 , A61P31/04
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular a Gram-positive bacterial complicated infection of skin and soft tissue. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection.
摘要翻译： 本发明提供了用于治疗细菌感染的方法和组合物。 本发明的方法包括施用达巴万星用于治疗细菌感染，特别是革兰氏阳性细菌复合皮肤和软组织感染。 给药方案包括每周一次给予达巴万星，达巴万星通常在血液中保持治疗水平至少一周，为细菌感染提供长时间的治疗作用。
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4.发明申请Methods of administering dalbavancin for treatment of skin and soft tissue infections 审中-公开给予达巴万星治疗皮肤和软组织感染的方法公开(公告)号：US20050032721A1
公开(公告)日：2005-02-10
申请号：US10942197
申请日：2004-09-15
申请人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard White
发明人： Marco Cavaleri , Daniela Jabes , Timothy Henkel , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard White
IPC分类号： A61K31/70 , A61K31/704 , A61K38/12 , A61K38/14 , A61P31/04
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular an uncomplicated Gram-positive bacterial infection of skin and soft tissue. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection.
摘要翻译： 本发明提供了用于治疗细菌感染的方法和组合物。 本发明的方法包括给予达巴万星治疗细菌感染，特别是皮肤和软组织的不复杂革兰氏阳性细菌感染。 给药方案包括每周一次给予达巴万星，达巴万星通常在血液中保持治疗水平至少一周，为细菌感染提供长时间的治疗作用。
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5.发明申请Compositions and methods for treating bacterial infections with protein-dalbavancin complexes 审中-公开用蛋白质 - 达巴万星复合物治疗细菌感染的组合物和方法公开(公告)号：US20050004011A1
公开(公告)日：2005-01-06
申请号：US10713924
申请日：2003-11-14
申请人： Marco Cavaleri , Luigi Colombo , Timothy Henkel , Daniela Jabes , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard White
发明人： Marco Cavaleri , Luigi Colombo , Timothy Henkel , Daniela Jabes , Adriano Malabarba , Giorgio Mosconi , Martin Stogniew , Richard White
IPC分类号： A61K31/70 , A61K31/704 , A61K38/12 , A61K38/14 , A61P31/04 , A61K38/16 , C07K14/765
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of dalbavancin for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue, under conditions where a protein-dalbavancin complex forms, or administering a protein-dalbavancin complex. Dosing regimes include once weekly administration of dalbavancin, which often remains at therapeutic levels in the bloodstream for at least one week, providing prolonged therapeutic action against a bacterial infection.
摘要翻译： 本发明提供了用于治疗细菌感染的方法和组合物。 本发明的方法包括在形成蛋白质 - 达巴万星复合物的条件下，给予达巴万星治疗细菌感染，特别是皮肤和软组织的革兰氏阳性细菌感染，或施用蛋白质 - 达巴万星复合物。 给药方案包括每周一次给予达巴万星，达巴万星通常在血液中保持治疗水平至少一周，为细菌感染提供长时间的治疗作用。
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6.发明授权公开(公告)号：US07655676B2
公开(公告)日：2010-02-02
申请号：US10518802
申请日：2003-06-06
IPC分类号： A61K31/44 , A01N43/78 , C07D277/60 , C07D417/00 , C07D513/00
CPC分类号： A61K38/12
摘要： Use of the compound of formula (I) and the pharmaceutically acceptable addition salts thereof for the manufacture of a medicament for topical treatment or 5 prevention of acne formula (I) wherein: R represents methoxymethyl, R1 represents methyl, Rz represents methyl, Y represents the group formula (II) The compound of formula (I) and the pharmaceutically acid addition salts thereof show selective activity against propionibacterium acne and are suitable for use in a method of treatment or prevention of acne.
摘要翻译： 式（I）化合物及其药学上可接受的加成盐在制备用于局部治疗的药物或5防止痤疮配方（I）中的用途，其中：R表示甲氧基甲基，R1表示甲基，Rz表示甲基，Y表示 基团式（II）式（I）化合物及其药学上可接受的酸加成盐显示对丙酸杆菌的选择性活性，适用于治疗或预防痤疮的方法。
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7.发明申请公开(公告)号：US20070117825A1
公开(公告)日：2007-05-24
申请号：US10518802
申请日：2003-06-06
IPC分类号： A61K31/4745
CPC分类号： A61K38/12
摘要： Use of the compound of formula (I) and the pharmaceutically acceptable addition salts thereof for the manufacture of a medicament for topical treatment or 5 prevention of acne formula (I) wherein: R represents methoxymethyl, R1 represents methyl, Rz represents methyl, Y represents the group formula (II) The compound of formula (I) and the pharmaceutically acid addition salts thereof show selective activity against propionibacterium acne and are suitable for use in a method of treatment or prevention of acne.
摘要翻译： 式（I）化合物及其药学上可接受的加成盐在制备用于局部治疗的药物或5防止痤疮配方（I）中的用途，其中：R表示甲氧基甲基，R1表示甲基，Rz表示甲基，Y表示 基团式（II）式（I）化合物及其药学上可接受的酸加成盐显示对丙酸杆菌的选择性活性，适用于治疗或预防痤疮的方法。
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8.发明申请公开(公告)号：US20090305953A1
公开(公告)日：2009-12-10
申请号：US12474438
申请日：2009-05-29
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of a mixture of dalbavancin multimers and monomers for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Compositions comprise a mixture of dalbavancin multimer and monomer and a stabilizer, such as dextrose.
摘要翻译： 本发明提供了用于治疗细菌感染的方法和组合物。 本发明的方法包括施用达巴万星多聚体和用于治疗细菌感染的单体的混合物，特别是皮肤和软组织的革兰氏阳性细菌感染。 组合物包括达巴万星多聚体和单体以及稳定剂如葡萄糖的混合物。
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公开(公告)号：US20050090433A1
公开(公告)日：2005-04-28
申请号：US10493558
申请日：2003-11-14
IPC分类号： A61K31/70 , A61K31/704 , A61K38/12 , A61K38/14 , A61P31/04
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of a mixture of dalbavancin multimers and monomers for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Compositions comprise a mixture of dalbavancin multimer and monomer and a stabilizer, such as dextrose.
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公开(公告)号：US20050130909A1
公开(公告)日：2005-06-16
申请号：US10714166
申请日：2003-11-14
IPC分类号： A61K31/70 , A61K31/704 , A61K38/12 , A61K38/14 , A61P31/04
CPC分类号： A61K38/14 , A61K31/70 , A61K31/704 , A61K38/00 , A61K2300/00
摘要： The invention provides methods and compositions for treatment of bacterial infections. Methods of the invention include administration of a mixture of dalbavancin multimers and monomers for treatment of a bacterial infection, in particular a Gram-positive bacterial infection of skin and soft tissue. Compositions comprise a mixture of dalbavancin multimer and monomer and a stabilizer, such as dextrose.
摘要翻译： 本发明提供了用于治疗细菌感染的方法和组合物。 本发明的方法包括施用达巴万星多聚体和用于治疗细菌感染的单体的混合物，特别是皮肤和软组织的革兰氏阳性细菌感染。 组合物包括达巴万星多聚体和单体以及稳定剂如葡萄糖的混合物。
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