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    Utilization of derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain
    8.
    发明授权
    Utilization of derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain 有权
    四氢吡啶衍生物（或4-羟基哌啶） - 丁基二醇在制备用于治疗疼痛的药物中的应用

    公开(公告)号：US06384055B1

    公开(公告)日：2002-05-07

    申请号：US09743085

    申请日：2001-02-13

    申请人： Ramon Merce-Vidal ,  Jordi Frigola-Constansa

    发明人： Ramon Merce-Vidal ,  Jordi Frigola-Constansa

    IPC分类号： A61K31445

    CPC分类号： A61K31/454 ,  A61K31/4439

    摘要： Derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols of formula (I), wherein R1, R2 and R3, which are similar or different, represent each of them hydrogen, halogen, alkyl C1-C4, trifluoromethyl, hydroxyl, alkoxyl, or two adjacent radicals can form a ring; A is a C atom and the dotted line represents an additional bond, or A is a C atom joined to a hydroxyl group and the dotted line represents absence of additional bond; Z1 is N or CR4; Z2 is N or CR5; Z4 is N or CR7; and R4, R5, R6 and R7, which different, represent hydrogen, halogen, alkyl C1-C4, aryl or substituted aryl, or two adjacent radicals can form part of another ring. These derivatives are useful for the treatment of acute pain, neuropathic pain or nociceptive pain in mammals, including human beings.

    摘要翻译： 式（I）的四氢吡啶（或4-羟基哌啶） - 丁基二醇的衍生物，其中相同或不同的R 1，R 2和R 3各自表示氢，卤素，C 1 -C 4烷基，三氟甲基，羟基，烷氧基或 两个相邻的基团可以形成环; A是C原子，虚线表示附加键，或A是连接到羟基的C原子，虚线表示不存在附加键; Z1是N或CR4; Z2为N或CR5; Z4是N或CR7; 和不同的代表氢，卤素，烷基C1-C4，芳基或取代的芳基或两个相邻基团的R4，R5，R6和R7可以形成另一个环的一部分。 这些衍生物可用于治疗哺乳动物（包括人类）的急性疼痛，神经性疼痛或伤害性疼痛。