公开(公告)号：US20070004705A1

公开(公告)日：2007-01-04

申请号：US10539145

申请日：2003-12-04

申请人： Maria Brasca ,  Raffaella Amici ,  Daniele Fancelli ,  Marcell Nesi ,  Paolo Orsini ,  Fabrizio Orzi ,  Patrick Roussel ,  Anna Vulpetti ,  Paolo Pevarello

发明人： Maria Brasca ,  Raffaella Amici ,  Daniele Fancelli ,  Marcell Nesi ,  Paolo Orsini ,  Fabrizio Orzi ,  Patrick Roussel ,  Anna Vulpetti ,  Paolo Pevarello

IPC分类号： A61K31/551 ,  A61K31/496 ,  A61K31/4747 ,  A61K31/454 ,  A61K31/4162 ,  C07D487/10 ,  C07D487/02

CPC分类号： C07D487/04 ,  A61K31/4162 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  A61N5/10

摘要： Compounds represented by formula (Ia) or (Ib) and wherein R and R1 are as defined in the description, and pharmaceutically acceptable salts thereof, are disclosed; the said compounds are useful in the treatment of cell cycle proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.

摘要翻译： 通式（Ia）或（Ib）表示的化合物及其药学上可接受的盐及其药学上可接受的盐被公开，其中R 1和R 1'如说明书中所定义。 所述化合物可用于治疗细胞周期增殖性疾病，例如， 与改变的细胞周期依赖性激酶活性相关的癌症。

公开(公告)号：US20070185143A1

公开(公告)日：2007-08-09

申请号：US10557565

申请日：2004-04-27

申请人： Gabriella Traquandi ,  Maria Brasca ,  Roberto D'Alessio ,  Paolo Polucci ,  Fulvia Roletto ,  Anna Vulpetti ,  Paolo Pevarello ,  Achille Panzeri ,  Francesca Quartieri ,  Ron Ferguson ,  Paola Vianello ,  Daniele Fancelli

发明人： Gabriella Traquandi ,  Maria Brasca ,  Roberto D'Alessio ,  Paolo Polucci ,  Fulvia Roletto ,  Anna Vulpetti ,  Paolo Pevarello ,  Achille Panzeri ,  Francesca Quartieri ,  Ron Ferguson ,  Paola Vianello ,  Daniele Fancelli

IPC分类号： A61K31/505

CPC分类号： C07D487/14 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  C07D231/56 ,  C07D239/72 ,  C07D401/10 ,  C07D403/14 ,  C07D413/14 ,  C07D487/04

摘要： Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention maybe useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer”.

摘要翻译： 公开了说明书中定义的式（Ia）或（Ib）的吡唑并喹唑啉衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物可用于治疗与抑制性蛋白激酶活性相关的疾病如癌症“。

公开(公告)号：US20050176796A1

公开(公告)日：2005-08-11

申请号：US10505200

申请日：2003-02-18

申请人： Roberto D'Alessio ,  Alberto Bargiotti ,  Maria Brasca ,  Antonella Ermoli ,  Paolo Pevarello ,  Marcellino Tibolla

发明人： Roberto D'Alessio ,  Alberto Bargiotti ,  Maria Brasca ,  Antonella Ermoli ,  Paolo Pevarello ,  Marcellino Tibolla

IPC分类号： C07D231/54 ,  A61K31/415 ,  A61K31/4162 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61K31/551 ,  A61K45/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/08 ,  A61P13/12 ,  A61P17/06 ,  A61P19/02 ,  A61P25/00 ,  A61P25/28 ,  A61P31/12 ,  A61P35/00 ,  A61P35/04 ,  A61P37/06 ,  A61P43/00 ,  C07D403/04 ,  C07D403/06 ,  C07D413/04 ,  C07D471/04 ,  C07D471/14 ,  C07D471/22 ,  C07D487/04 ,  C07D487/14 ,  C07D495/04 ,  C07D498/14 ,  A61K31/4188

CPC分类号： C07D403/04 ,  A61K31/415 ,  C07D231/54 ,  C07D403/06 ,  C07D413/04 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/14 ,  C07D495/04

摘要： Compounds which are tricyclic pyrazole derivatives and analogues thereof, as set forth in the specification, or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

摘要翻译： 公开了如说明书中所述的三环吡唑衍生物及其类似物或其药学上可接受的盐以及包含它们的药物组合物的化合物。 这些化合物或组合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。

公开(公告)号：US20050256151A1

公开(公告)日：2005-11-17

申请号：US11020793

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

IPC分类号： C07D471/04 ,  G01N33/53 ,  A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

公开(公告)号：US20070112020A1

公开(公告)日：2007-05-17

申请号：US11271191

申请日：2005-11-11

申请人： Ermes Vanotti ,  Francesco Angelucci ,  Alberto Bargiotti ,  Maria Brasca ,  Antonella Ermoli ,  Maria Menichincheri

发明人： Ermes Vanotti ,  Francesco Angelucci ,  Alberto Bargiotti ,  Maria Brasca ,  Antonella Ermoli ,  Maria Menichincheri

IPC分类号： A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： The present invention is directed to compounds of the formula or pharmaceutically acceptable salts, prodrug, solvate or optical isomer thereof, pharmaceutical compositions containing same and use thereof for treating diseases linked to disregulated cell proliferation or to disregulated protein kinase.

摘要翻译： 本发明涉及下式的化合物或其药学上可接受的盐，前体药物，溶剂合物或旋光异构体，含有该化合物的药物组合物及其用于治疗与细胞增殖失调或失调的蛋白激酶相关的疾病的用途。

公开(公告)号：US20050209269A1

公开(公告)日：2005-09-22

申请号：US11020794

申请日：2004-12-23

申请人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

发明人： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Dania Tesei ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

IPC分类号： C07D471/04 ,  A61K31/4745 ,  C07D471/02

CPC分类号： C07D471/04

摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

摘要翻译： 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。