公开(公告)号：US08551958B2

公开(公告)日：2013-10-08

申请号：US13015980

申请日：2011-01-28

申请人： Maria Grazia Rimoli ,  Antonio Calignano ,  Rosario Cuomo ,  Gianpiero Boatto ,  Enrico Abignente ,  Daniela Melisi ,  Annalisa Curcio ,  Elvira Luongo ,  Giovanna La Rana ,  Oscar Sasso ,  Giovanni Sarnelli ,  Roberto Russo ,  Maria Nieddu ,  Carla Cirillo ,  Salvatore De Lucia

发明人： Maria Grazia Rimoli ,  Antonio Calignano ,  Rosario Cuomo ,  Gianpiero Boatto ,  Enrico Abignente ,  Daniela Melisi ,  Annalisa Curcio ,  Elvira Luongo ,  Giovanna La Rana ,  Oscar Sasso ,  Giovanni Sarnelli ,  Roberto Russo ,  Maria Nieddu ,  Carla Cirillo ,  Salvatore De Lucia

IPC分类号： A61K31/7024 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07H13/10

CPC分类号： A61K31/7024 ,  A61K47/549 ,  C07H13/02 ,  C07H13/04 ,  C07H13/08 ,  C07H13/10

摘要： Pro-drugs of all non-steroidal anti-inflammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L-enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.

摘要翻译： 所有具有由酯基衍生的游离酸功能的所有非甾体抗炎药的前药具有下面给出的一般结构式（I），其中A是：阿司匹林，二氟尼柳，苯磺酸盐，异丙酸，双氯芬酸，吲哚美辛，舒林酸， 酮咯酸，布洛芬，萘普生，酮洛芬，非诺洛芬，氟比洛芬，甲芬那酸，甲酰胺酸，氟芬那酸，尼氟酸，其中酯基R中的糖可以是糖（其中醛糖或酮糖戊糖或选自 核糖，葡萄糖，半乳糖，甘露糖，阿拉伯糖，半乳糖，阿洛糖，阿卓糖，古洛糖，阿糖和托洛糖及其取代衍生物的D-和L-对映体组如葡萄糖胺，半乳糖胺，N-乙酰葡糖胺，N-乙酰半乳糖胺 ，N-乙酰基核糖胺），二糖，三糖或寡糖。

公开(公告)号：US06656972B2

公开(公告)日：2003-12-02

申请号：US10054394

申请日：2002-01-22

申请人： Antonio Calignano ,  Giovanna La Rana ,  Andrea Guiffrida ,  Daniele Piomelli

发明人： Antonio Calignano ,  Giovanna La Rana ,  Andrea Guiffrida ,  Daniele Piomelli

IPC分类号： A61K3116

CPC分类号： A61K31/23 ,  A61K31/164 ,  A61K2300/00

摘要： Novel pharmaceutical therapeutic compositions and methods for using same for the treatment of pain experienced by an individual are provided. The compositions contain at least one member selected from among anandamide and palmitylethanolamide.

公开(公告)号：US06348498B1

公开(公告)日：2002-02-19

申请号：US09322843

申请日：1999-05-28

申请人： Antonio Calignano ,  Giovanna La Rana ,  Andrea Guiffrida ,  Daniele Piomelli

发明人： Antonio Calignano ,  Giovanna La Rana ,  Andrea Guiffrida ,  Daniele Piomelli

IPC分类号： A61K3116

CPC分类号： A61K31/23 ,  A61K31/164 ,  A61K2300/00

摘要： Novel pharmaceutical therapeutic compositions and methods for using same for the treatment of pain experienced by an individual are provided. The compositions contain at least one member selected from among anandamide and palmitylethanolamide.

摘要翻译： 提供了新颖的药物治疗组合物和用于治疗个体经历的疼痛的方法。 组合物含有至少一种选自anandamide和palmitylethanolamide的成员。