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1.发明授权Derivatives of 1-diphenylmethyl piperazine and their use as antihistamines 失效1-二苯基甲基哌啶的衍生物及其作为抗生素的用途
公开(公告)号：US5166205A
公开(公告)日：1992-11-24
申请号：US735431
申请日：1991-07-25
IPC分类号： A61K31/495 , A61P37/08 , A61P43/00 , C07D207/32 , C07D207/325 , C07D231/14 , C07D231/16 , C07D233/56 , C07D249/08 , C07D521/00
CPC分类号： C07D207/325 , C07D231/12 , C07D231/14 , C07D231/16 , C07D233/56 , C07D249/08
摘要： The present invention relates to novel derivatives of 1-diphenylmethyl piperazinyl, characterized in that they correspond to the general formula I, and their therapeutically acceptable salts, ##STR1## in which: R.sub.1 and R.sub.2, equal or different, represent a hydrogen atom, a halogen, a lower alkyl radical, a hydroxy radical, an alkoxy radical, an alkyl carboxylate radical, an aryl or substituted aryl radical,n may have the values 2 to 4,X, Y, Z and W, equal or different, represent a nitrogen atom or a carbon atom linked to a hydrogen atom, a halogen or to another alkyl, aryl, carboxyalkyl, carbonyl, hydroxyl, sulfonyl and alkylsulfonyl radical.The present invention also relates to the process of preparing these compounds and their use for the manufacture of medicaments intended for prophylaxis and for the treatment of various allergic disorders caused by histamine.
摘要翻译： 本发明涉及1-二苯基甲基哌嗪基的新衍生物，其特征在于它们对应于通式Ⅰ及其治疗上可接受的盐，其中：R1和R2等同或不同，表示氢原子， 卤素，低级烷基，羟基，烷氧基，烷基羧酸酯基，芳基或取代的芳基，n可以具有2至4，X，Y，Z和W相等或不同，表示 连接到氢原子的氮原子或碳原子，卤素或另一个烷基，芳基，羧基烷基，羰基，羟基，磺酰基和烷基磺酰基。 本发明还涉及制备这些化合物的方法及其制备用于预防和治疗由组胺引起的各种过敏性疾病的药物的用途。
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公开(公告)号：US5214040A
公开(公告)日：1993-05-25
申请号：US863208
申请日：1992-04-03
IPC分类号： A61K31/55 , A61K9/20 , A61K31/4184 , A61K31/496 , A61K31/551 , A61P25/20 , A61P29/00 , A61P37/08 , A61P43/00 , C07D231/12 , C07D231/14 , C07D235/14 , C07D235/30 , C07D403/12 , C07D403/14 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D403/12
摘要： The present invention relates to novel benzimidazole derivatives characterized in that they are of the general formula I, and their therapeutically acceptable salts, ##STR1## in which: R.sub.1 and R.sub.2, which are identical or different, represent a hydrogen or a halogen atom, a lower alkyl radical, a hydroxyl radical, an alkoxy radical, an alkyl carboxylate radical, or an aryl or substituted aryl radical,n may take the values 0 or 1,m may take the values 2 to 4,X, Y, Z and W, which are identical or different, and which may even form part of another aromatic or nonaromatic ring, represent a nitrogen atom or a carbon atom linked to a hydrogen or to a halogen atom, or to another alkyl, aryl, carboxyalkyl, carboxylic, hydroxyl, alkyl hydroxyl, sulphonic or alkylsulphonic radical.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，其特征在于它们具有通式Ⅰ及其治疗上可接受的盐，其中：R1和R2相同或不同，表示氢或卤素原子， 低级烷基，羟基，烷氧基，烷基羧酸酯基或芳基或取代的芳基，n可以取值0或1，m可以取值2至4，X，Y，Z和 W是相同或不同的，并且甚至可以形成另一个芳族或非芳族环的一部分，代表与氢或卤素原子连接的氮原子或碳原子，或另一个烷基，芳基，羧烷基，羧基， 羟基，烷基羟基，磺酸基或烷基磺酰基。
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公开(公告)号：US5182280A
公开(公告)日：1993-01-26
申请号：US735653
申请日：1991-07-25
IPC分类号： A61K31/495 , A61K31/496 , A61P37/08 , A61P43/00 , C07D207/325 , C07D231/10 , C07D233/54 , C07D235/14 , C07D249/04 , C07D249/08 , C07D257/04 , C07D259/00 , C07D295/12 , C07D403/12 , C07D403/14 , C07D521/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D403/12
摘要： The present invention relates to novel compounds derived from benzimidazole, characterized in that they correspond to the formula I, or their therapeutically acceptable salts, ##STR1## in which: R.sub.1 and R.sub.2, equal or different, represent a hydrogen atom, a halogen, a lower alkyl radical, a hydroxy radical, an alkoxy radical, an alkyl carboxylate radical, an aryl or substituted aryl radical,n may have the values 0 or 1,m may have the values 2 to 4,X, Y, Z and W, equal or different, represents a nitrogen atom or a carbon atom bonded to a hydrogen atom, a halogen or another alkyl, aryl, alkoxycarbonyl, carboxy, hydroxyl, sulfonic and alkylsulfonic radical. The present invention relates also to the treatment of various allergic disorders caused by histamine.
摘要翻译： 本发明涉及衍生自苯并咪唑的新化合物，其特征在于它们对应于式I或其治疗上可接受的盐，其中：R 1和R 2等同或不同，表示氢原子，卤素， 低级烷基，羟基，烷氧基，烷基羧酸酯基，芳基或取代的芳基，n可以具有0或1的数值，m可以具有值2至4，X，Y，Z和W 相同或不同，表示与氢原子键合的氮原子或碳原子，卤素或其它烷基，芳基，烷氧基羰基，羧基，羟基，磺酸基和烷基磺酸根。 本发明还涉及由组胺引起的各种过敏性疾病的治疗。
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