公开(公告)号：US20090270418A1

公开(公告)日：2009-10-29

申请号：US12350722

申请日：2009-01-08

申请人： Marianne Sloss ,  Jeffrey McKenna ,  Won Hyung Yoon ,  Stephen Norris ,  Dale Robinson ,  Jason Parnes ,  Graziella Shevlin ,  Paul Erdman ,  Robert Hilgraf ,  Ronald Albers ,  Sayee Hegde ,  Andrew Wallace ,  Henry Chan ,  Loui Madakamutil ,  Heather Raymon

发明人： Marianne Sloss ,  Jeffrey McKenna ,  Won Hyung Yoon ,  Stephen Norris ,  Dale Robinson ,  Jason Parnes ,  Graziella Shevlin ,  Paul Erdman ,  Robert Hilgraf ,  Ronald Albers ,  Sayee Hegde ,  Andrew Wallace ,  Henry Chan ,  Loui Madakamutil ,  Heather Raymon

IPC分类号： A61K31/497 ,  C07D403/12 ,  A61P35/00 ,  C12N9/99

CPC分类号： C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D413/14 ,  C07D417/14

摘要： Provided herein are Pyrazole Pyrazine Amine Compounds having the following structure: Wherein Q and R1-R3 are as defined herein, compositions comprising an effective amount of a Pyrazole Pyrazine Amine Compound and methods for treating or preventing inflammatory conditions, immunological conditions, cancer, neurodegenerative diseases, age-related diseases, cardiovascular diseases and metabolic conditions, or conditions treatable or preventable by inhibition of an IKK, or an IKK pathway, comprising administering an effective amount of a Pyrazole Pyrazine Amine Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的吡唑吡嗪胺化合物：其中Q和R 1 -R 3如本文所定义，包含有效量的吡唑吡嗪胺化合物的组合物和治疗或预防炎性病症，免疫学条件，癌症，神经变性疾病的方法 ，年龄相关疾病，心血管疾病和代谢病症，或通过抑制IKK或IKK途径可治疗或可预防的病症，包括向有需要的患者施用有效量的吡唑吡嗪胺化合物。

公开(公告)号：US08110578B2

公开(公告)日：2012-02-07

申请号：US12605791

申请日：2009-10-26

申请人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

IPC分类号： A61K31/497

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US20120071658A1

公开(公告)日：2012-03-22

申请号：US13295533

申请日：2011-11-14

申请人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US08507492B2

公开(公告)日：2013-08-13

申请号：US13295513

申请日：2011-11-14

申请人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

IPC分类号： A61K31/497

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US08492381B2

公开(公告)日：2013-07-23

申请号：US13295533

申请日：2011-11-14

申请人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

IPC分类号： A61K31/497

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。

公开(公告)号：US20120059164A1

公开(公告)日：2012-03-08

申请号：US13295513

申请日：2011-11-14

申请人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

公开(公告)号：US20100216781A1

公开(公告)日：2010-08-26

申请号：US12605791

申请日：2009-10-26

申请人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

发明人： Sophie Perrin-Ninkovic ,  Roy L. Harris ,  John Sapienza ,  Graziella Shevlin ,  Patrick Papa ,  Branden Lee ,  Garrick Packard ,  Lida Tehrani ,  Jingjing Zhao ,  Jennifer Riggs ,  Jason Parnes ,  Deborah Mortensen ,  Weiming Xu ,  Loui Madakamutil ,  Kimberly Fultz ,  Rama K. Narla ,  Sabita Sankar ,  Jan Elsner

IPC分类号： A61K31/4985 ,  C07D487/04 ,  C07D487/10 ,  C07D498/14 ,  A61K31/5377 ,  A61K31/5383 ,  A61P35/00 ,  A61P29/00 ,  A61P37/00 ,  A61P25/00 ,  A61P3/10 ,  A61P3/04 ,  A61P9/00 ,  A61P19/02 ,  A61P11/00 ,  C12N9/99 ,  A61P1/00

CPC分类号： C07D487/04 ,  C07D241/20 ,  C07D471/04 ,  C07D471/14 ,  C07D487/10 ,  C07D487/14 ,  C07D498/14

摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R 1 -R 4如本文所定义，包含有效量的杂芳基化合物的组合物以及用于治疗或预防癌症，炎症状况，免疫学条件，神经变性疾病，糖尿病，肥胖症，神经系统疾病 疾病，年龄相关疾病或心血管疾病，包括向有需要的患者施用有效量的杂芳基化合物。